Targeting oxidative stress, a crucial challenge in renal transplantation outcome (original) (raw)

Oxidative stress caused by ischemia/reperfusion (I/R) is a significant factor affecting renal transplantation outcomes. During transplantation, the sudden restoration of blood flow to the kidney leads to the generation of reactive oxygen species (ROS) and nitric oxides (NO), which contribute to cell death and tissue damage. Effective management of oxidative stress is crucial, particularly with the increasing number of successful organ transplants, as it directly impacts organ preservation. This review discusses the roles of ROS and NO in oxidative stress, potential pharmacological interventions, and highlights new therapeutic targets such as ferrostatin-1 and quercetin that may mitigate I/R injury and improve kidney transplant outcomes.