Biological Markers to Study the Morphological Modifications Induced by Perinatal Asphyxia (original) (raw)

Perinatal asphyxia (PA) is a significant neurodevelopmental impairment contributing to neonatal mortality and various long-term disorders. This study investigates cytoskeletal and synaptic alterations in the central nervous system (CNS) of a murine model subjected to severe PA. Utilizing advanced imaging techniques, we observed progressive morphological changes in the neostriatum and hippocampus, including increased F-actin staining, glial dysfunction markers, and pronounced postsynaptic density degeneration over a six-month period. These results suggest that cytoskeletal modifications by PA may underlie neuronal damage, offering insights into potential therapeutic strategies.