Chromosomes in adipose tissue tumors. An evaluation of 75 cases (original) (raw)

This study evaluates the cytogenetic profiles of 75 adipose tissue tumors, including solitary and multiple lipomas as well as malignant liposarcomas. Four cytogenetic subgroups were identified among the solitary lipomas, with 46 exhibiting clonal chromosomal aberrations. The findings reveal variations in chromosome complements, predominant karyotype characteristics, and correlations between chromosomal patterns and clinicopathological data. Additionally, abnormalities involving the 12q13-14 region were confirmed, alongside a newly identified subgroup affecting the 6p region. The study establishes connections between specific chromosomal alterations and histological subtypes of liposarcomas.