HTLV-1 infection in acute t- lymphocytic leukemia/lymphoma (original) (raw)
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Hematological Oncology, 2006
In a study of 7498 American men of Japanese ancestry in Hawaii, 26 incident cases of leukemia or non-Hodgkin's lymphoma were identified after a follow-up period of 19 years. Two of the cases, who were brothers, were diagnosed with adult T-cell leukemia/lymphoma (ATL). Both of these brothers had human Tcell lymphotropic virus type I (HTLV-I) antibodies in their stored serum which were obtained 4 and 18 years before diagnosis. None of the 24 patients with other hematologic malignancies or the 26 matched controls were HTLV-I antibody positive. This finding lends further support for a role of HTLV-I in the etiology of adult T-cell leukemia/lymphoma.
The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma
Blood, 1983
The human T-cell leukemia/lymphoma virus (HTLV) is a novel type-C retrovirus isolated from patients with Tlymphoproliferative malignancies. Thirteen cases of HTLVassociated malignancy from US centers were studied in detail. Ten of these cases share common clinical features and define a typical virus-associated adult T-cell leukemia! lymphoma (ATI). All ten patients presented with Ann Arbor stage IV lymphoma because of skin involvement. bone marrow involvement. or lymphomatous leptomeningitis. Lymphadenopathy occurred in 7 of 10 patients at presentation. and the malignant cells were cytologically pleomorphic. Leukemia occurred in 60% of the patients at presentation. Hypercalcemia was found initially in two
Indian Journal of Hematology and Blood Transfusion, 2012
Adult T cell leukaemia/lymphoma (ATLL) is a rare T lymphoproliferative disorder which is etiologically linked with human T cell lymphotropic virus type-1 (HTLV-1). HTLV-1 is endemic in Japan, Caribbean and Africa. The highest incidence of ATLL is in Japan although sporadic cases have been reported elsewhere in the world. We describe a case of ATLL with an unusual presentation with clinic-pathological correlation and autopsy confirmation. A 56 year old male was referred to Command Hospital (Southern Command) for an incidental finding of lymphocytosis on a routine Hemogram. Clinical examination did not reveal hepatosplenomegaly, lymphadenopathy, jaundice or skin lesions. Laboratory investigations showed lymphocytosis with predominance of atypical lymphomonocytoid cells. Immunophenotyping of the bone marrow mononuclear cells showed positivity for CD45, CD2, CD3, CD4, CD5 and negative for CD7, CD8, CD13, CD33, CD19, which is characteristic of ATLL phenotype. Clonality was confirmed by PCR for TCR gene rearrangement on post mortem tissue. He succumbed to his illness after 40 days of initial presentation and 16 days of being diagnosed as ATLL. Here, we discuss the pathogenesis and characteristics of ATLL with clinico-pathological correlation and autopsy confirmation.
Blood, 1996
Tumorous and nontumorous samples from patients with various forms of adult T-cell leukemia/lymphoma (ATLL) were analyzed using the sensitive inverse polymerase chain reaction (PCR) technique. In all samples, oligoclonal expansion of human T-cell leukemia virus (HTLV)-1 bearing T cells were detected, even for the tumorous samples that were mainly monoclonal by Southern blotting. For one case of smouldering ATLL, chemotherapy apparently reduced the number of detectable clones. Taken together with similar data on asymptomatic and symptomatic HTLV-1 carriers without malignancy, it would appear that ATLL appears on a prior background of HTLV-1-initiated oligoclonal expansion.
Cancer, 1985
The human T-cell leukemia virus type-] (HTLV-I) is a unique, exogenous, horizontally transmitted retrovirus which is T-cell tropic, and has been associated with a specific type of aggressive leukemia/ lymphoma of mature T-cell origin. In a Survey of lymphoid malignancies in Jamaia, antimies to HTLV-I were also found in 6 of 17 patients with chronic. lyrnphocytic leukemia (CLL), raising the possibiiity of an etiologic relatianship. Further studies were undertaken on one of these padents to clarify the nature of the disease and possible virus relationship. CeH surface marker analysis of her peripheral b l w d cells documented that the majority of circulating lymphocytes were B-cells. DNAcloned probe analysis with a complete HTLV-I proviral genome of these peripheral malignant B-cells, was negative for intwated virus. A Txell line was established in culture from her peripheral blood. The presence of HTLV-I in the cultured T-cell line was established by the detection of expressed viral specific gag protein p-19 and proviral DNA. Thus, a B-cell lymphoid malignancy can occur in the presence of HTLV-I infected T-cells, suggesting the possibility of an indirect leukemogenic mechanism. Cmcer 56:495-499, 1985. T wo DIsTrNCr but distantly related type-C retroviruses, HTLV-I and HTLV-11, have been isolated and characterized from humans with T-cell malignanciw.Ib2 Both HTLV-I and HTLV-I1 infect and transform T-~ells.~+' HTLV-I infection has been previously linked with a specific type of human adult T-cell leukemia/ lymphoma (ATL) which is found primarily in areas where HTLV-I infection is endemic in the general ~p~l a t i o n .~,~ Taken together, these data clearly link HTLV-1 to the cause of some human T-cell malignancies. Funk t: :nore, surprisingly, antibodies t o the virus have k e n detected in certain other types of leukemias from -' Environmental Epidemiolw Branch,