Specificity of insulin-like growth factor binding to type-II IGF receptors in rabbit mammary gland and hypophysectomized rat liver (original) (raw)

The research investigates the binding specificity of insulin-like growth factors (IGFs) to type-II IGF receptors in the rabbit mammary gland and hypophysectomized rat liver. Using competitive binding assays, the study reports varying binding affinities of different IGF isoforms, with IGF-II demonstrating significant binding potency in both tissue types. The findings contribute to the understanding of IGF receptor interactions and potential implications for growth regulation in mammalian tissues.