Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses (original) (raw)

AI-generated Abstract

Toll-like receptors (TLRs), traditionally associated with innate immune cells, are also expressed in T cells and play a significant role in enhancing T cell responses to vaccination, particularly in the context of cancer immunotherapy. This review discusses how increasing TLR expression in T cells can improve their reactivity to TLR agonists, improving anti-tumor immunity. Evidence is presented that TLR signaling can bridge innate and adaptive immune responses, leading to enhanced CD8+ T cell responses which could be crucial for developing effective immunization strategies against tumors.