Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection (original) (raw)

2000, International Journal of Immunopharmacology

In this study, antiviral eect of black seed oil (BSO) from Nigella sativa was investigated using murine cytomegalovirus (MCMV) as a model. The viral load and innate immunity mediated by NK cells and Mf during early stage of the infection were analyzed. Intraperitoneal (i.p.) administration of BSO to BALB/c mice, a susceptible strain of MCMV infection, strikingly inhibited the virus titers in spleen and liver on day 3 of infection with 1 Â 10 5 PFU MCMV. This eect coincided with an increase in serum level of IFN-g. Although BSO treatment decreased both number and cytolytic function of NK cells on day 3 of infection, it increased numbers of Mf and CD4 + T cells. On day 10 of infection, the virus titer was undetectable in spleen and liver of BSO-treated mice, while it was detectable in control mice. Although spleen of both control and BSO-treated mice showed similar CTL activities on day 10 after infection, serum level of IFN-g in BSO-treated mice was higher. Furthermore, BSO treatment upregulated suppressor function of Mf in spleen. These results show that BSO exhibited a striking antiviral eect against MCMV infection which may be mediated by increasing of Mf number and function, and IFN-g production.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact