The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein (original) (raw)

Proceedings of the National Academy of Sciences of the United States of America, 2024

Abstract

There is increasing interest in the ability of proteins involved in cell adhesion to convert mechanical force into altered biochemistry. Cellular signal transduction is most often conducted through multiprotein scaffolds that consolidate, localize, and specify signaling inputs and outputs. This report bridges these fields by identifying an interaction between talin, a mechanosensitive adhesion protein, and PKA, a pleiotropic kinase with myriad cellular targets. Together, these observations form the foundation for a mechanotransduction pathway that utilizes forcedependent changes in protein conformation to establish a solid-state signaling complex well positioned to couple cellular tension to cellular communication.

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