Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients (original) (raw)

The study investigates the serum levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients compared to normoglycemic individuals. In a cohort of 198 obese Jordanian subjects, findings revealed that those with prediabetes and type 2 diabetes exhibited elevated levels of hepatocyte growth factor (HGF), nesfatin, and betatrophin, while levels of omentin, irisin, and oxytocin were significantly reduced. No significant differences were noted for FGF21 and endothelin between the groups. The study suggests the potential of these markers as targets for future diabetes treatment, pending more extensive longitudinal studies.