Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury (original) (raw)

Efficacy of Drpitor1a, a Dynamin-Related Protein 1 inhibitor, in Pulmonary Arterial Hypertension

Pierce Colpman

bioRxiv (Cold Spring Harbor Laboratory), 2023

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Dynamin-Related Protein 1 at the Crossroads of Cancer

Miguel Melo

Genes, 2018

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Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase

Kenneth Fish

Journal of Cell Biology, 2000

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The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity

Ngoc Tram Anh Chau

ACS Medicinal Chemistry Letters, 2012

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Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas

Kuan-Chih Chow

Modern Pathology, 2009

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Modulation of Dynamin-related Protein 1 (DRP1) Function by Increased O-linked-β-N-acetylglucosamine Modification (O-GlcNAc) in Cardiac Myocytes

JORGE LEONARDO SUAREZ SUAREZ

Journal of Biological Chemistry, 2012

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Modulation of Dynamin-related Protein 1 (DRP1) Function by Increased O-linked- -N-acetylglucosamine Modification (O-GlcNAc) in Cardiac Myocytes

Jorge Suárez

Journal of Biological Chemistry, 2012

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The Pthaladyns : GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening

Nick Gorgani

Journal of Medicinal Chemistry, 2010

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Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer

Meshach Asare-Werehene

BMC Cancer

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Synthesis of potent chemical inhibitors of dynamin GTPase

Joohyun Park

Bioorganic & Medicinal Chemistry Letters, 2010

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The Cytoskeletal Protein Ndel1 Regulates Dynamin 2 GTPase Activity

Su Shim

PLoS ONE, 2011

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Inhibition of Drp1 orchestrates the responsiveness of breast cancer cells to paclitaxel but insignificantly relieves paclitaxel-related ovarian damage in mice

DR. Adel Alalawy

Scientific Reports, 2023

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Drp1 loss-of-function reduces cardiomyocyte oxygen-dependence protecting the heart from ischemia-reperfusion injury

Jaime Riquelme, Christian Pennanen, Ramiro Zepeda, Gina Sánchez

Journal of Cardiovascular Pharmacology, 2014

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Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses

Peter Goettig

PLoS ONE, 2013

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Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure

David Ferguson

Journal of Biological Chemistry, 2015

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Small Molecule Inhibitors of Dynamin I GTPase Activity: Development of Dimeric Tyrphostins

Luke Odell

Journal of Medicinal Chemistry, 2005

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The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

Gabriel Arriba

Developmental Cell, 2001

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A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

Junjie Hu

Cell, 2009

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Inhibition of Dynamin by Dynole 34-2 Induces Cell Death following Cytokinesis Failure in Cancer Cells

Jayne Gilbert

Molecular Cancer Therapeutics, 2011

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Inhibition of Drp1 provides neuroprotection in vitro and in vivo

Carsten Culmsee

Cell Death & Differentiation, 2012

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The dynamins: Redundant or distinct functions for an expanding family of related GTPases?

Tiffany Cook

Proceedings of the National Academy of Sciences, 1997

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A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division

Damien Arnoult

2010

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Reducing expression of dynamin-related protein 1 increases radiation sensitivity of glioblastoma cells

Kuan-Chih Chow

bioRxiv (Cold Spring Harbor Laboratory), 2019

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Cardioprotection from ischemia-reperfusion injury due to Ras-GTPase inhibition is attenuated by glibenclamide in the globally ischemic heart

Ibrahim Benter

Cell Biochemistry and Function, 2007

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The GTPase dynamin binds to and is activated by a subset of SH3 domains

Oanh Truong

Cell, 1993

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Drp1 mediates caspase-independent type III cell death in normal and leukemic cells

Patricia Sancho, Victor J Yuste

Molecular and Cellular Biology, 2007

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Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

Feng Fu

Circulation Research, 2012

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Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells

Jeong-Won Lee

Anticancer research, 2016

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Correlation Between Self-Association Modes and GTPase Activation of Dynamin

David Jameson

Journal of Protein Chemistry

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