Synthesis, Inhibitory Properties on the Metabolic Enzymes and Antioxidant Activity of a New Series Benzimidazole Derivatives (original) (raw)

Synthesis and Antioxidant Properties of New Benzimidazole Derivatives

Politeknik dergisi, 2021

❖ Synthesized compounds were evaluated for their in vitro antioxidant activity. ❖ The structures of synthesized compounds were established on the basis of spectral data. ❖ Enzyme activity was calculated by spectrofluorimetric measurement of the amount of resorufin formed. ❖ The reducing power activities of the compounds were compared with BHT. ❖ Values were the means of three replicates ± Standard deviation.

Synthesis and antioxidant capacities of some new benzimidazole derivatives

In this study, we prepared some new oxadiazolyl benzimidazole derivatives and investigated their antioxidant properties by determination of microsomal NADPH-dependent inhibition of lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O-deethylase activity (EROD assay). Some of these compounds 20, 23 had slightly inhibitory effects (28%) on the lipid peroxidation levels at 10 -3 M concentration lower than standard BHT (65%). 5-[2-(Phenyl)-benzimidazol-1-yl-methyl]-2-mercapto-[1,3,4]-oxadiazole 16 was found to be more active than caffeine on the ethoxyresorufin O-deethylase activity with an IC 50 value of 2.0 6 10 -4 M.

Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006

New, except 1d, melatonin analogue benzimidazole derivatives were synthesized and characterized in the present study. The potential role of melatonin as an antioxidant by scavenging and detoxifying ROS raised the possibility that compounds that are analogous to melatonin can also be used for their antioxidant properties. Therefore the antioxidant effects of the newly synthesized compounds were investigated in vitro by means of their inhibitory effect on hydrogen peroxide-induced erythrocyte membrane lipid peroxidation (EMLP) and on various erythrocyte antioxidant enzymes viz. superoxide dismutase (SOD), catalase (CAT) and glucose-6-phosphate dehydrogenase (G6PD). The synthesized benzimidazole derivatives showed remarkable antioxidant activity in vitro in the H 2 O 2 -induced EMLP system. Furthermore their effects on various antioxidant enzymes are discussed and evaluated from the perspective of structure-activity relationships.

Synthesis and evaluation ofin vitroantioxidant capacities of some benzimidazole derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006

New, except 1d, melatonin analogue benzimidazole derivatives were synthesized and characterized in the present study. The potential role of melatonin as an antioxidant by scavenging and detoxifying ROS raised the possibility that compounds that are analogous to melatonin can also be used for their antioxidant properties. Therefore the antioxidant effects of the newly synthesized compounds were investigated in vitro by means of their inhibitory effect on hydrogen peroxide-induced erythrocyte membrane lipid peroxidation (EMLP) and on various erythrocyte antioxidant enzymes viz. superoxide dismutase (SOD), catalase (CAT) and glucose-6-phosphate dehydrogenase (G6PD). The synthesized benzimidazole derivatives showed remarkable antioxidant activity in vitro in the H 2 O 2-induced EMLP system. Furthermore their effects on various antioxidant enzymes are discussed and evaluated from the perspective of structure-activity relationships.

Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2007

Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPHdependent lipid peroxidation (LP) level, ethoxyresorufin O-deethylase (EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10 23 M concentration. Compounds 4c (100.0%), 4h (100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase (EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C.albicans whereas the others had weak effects.