Amelioration of renal structural changes in STZ-induced diabetic mice with ethanolic extract of Allium saralicum R.M. Fritsch (original) (raw)
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Food Science & Nutrition, 2021
Diabetes mellitus is a common metabolite disorder in both developing and developed countries (Kaczmarczyk-Sedlak et al., 2019). In this regard, the body ability to yield insulin reduce or insulin resistance occurs in the body (Kayar & Agin, 2019). The main clinical complications of the diabetes mellitus are weak cutaneous wound healing, reduced fibrinolytic activity, severe chronic atherosclerosis, hypertension, dyslipidemia, disturbed hematological parameters including erythrocyte aggregation, erythrocyte deformability
Asian Journal of Biomedical and Pharmaceutical Sciences, 2014
Histopathological effects of macerated Allium sativum (garlic) on cytoarchitectural alterations in the kidney of alloxan (150mg/kg) induced diabetic rats was investigated. Twenty five (25) weaning rats weighing between 105-205g were divided into five (5) groups of 5 rats each. Group I and group II served as the normal control (NC) and diabetic control group (DC) respectively. The diabetic experimental groups III,IV and V were administered macerated preparation of Allium sativum (garlic) at a dose of 6.6g/kg and standard pellets orally for 7,14 and 21 days respectively. Thereafter, the animals were sacrificed, kidney was extracted, weighed and fixed immediately in 10% formal saline, transported to the laboratory, processed to paraffin wax, cut at 5 microns, stained using Heamtoxylin and Eosin technique and observed histopathologically under light microscope. The result revealed, increase in cellular regeneration with prominent nuclear rearrangement in group III as slight, in group IV as moderate restoration and group V as complete restoration as compared to the normal non-diabetic group which revealed normal cellular architecture and diabetic control group II showed area of tubular necrosis, thickening and distortion of the basement membrane, glomerular damages and edematous convoluted tubules. Statistical value in the weight of the body and liver were not significant at the value (p >0.05) compared to control. These findings are suggestive of possible anti-diabetic and nephro-protective potentials played by the macerated preparation of Allium sativum (garlic) on kidney in single administration.
The Anti-Diabetic Effect of Ethanol Leaf-Extract of Allium sativum on Albino Rats
International Journal of Pharmacy and Medical Sciences, 2014
The anti-diabetic effect of ethanol leaf-extract of Allium sativum was investigated on 24 albino rats. The animals were grouped into four (A, B, C and D) containing six rats each. Diabetes was induced by intraperitonial administration of alloxan solution at 100mg/kg body weights to the experimental animals. The ethanol leaf-extract of Allium sativum was administered to the animals in groups A, B, C and D at 200mg/kg, 400mg/kg, 600mg/kg and 0mg/kg body weights respectively for two weeks through oral intubation. Blood samples were collected after the two-week period of administration of the extract. The ethanol leaf-extract of Allium sativum significantly (p<0.05) and dose-dependently reduced blood glucose concentration in albino rats.
2015
Effective regulation of blood glucose level is the most important factor for reducing risks of diabetic complications and this must be done without any side effects or interference with normal physiological function of the body which is not usually achievable with the conventional diabetic drugs. This has resulted in the current shift to the use of herbal preparation which is presumed to be effective, cheap with no side effects. Most noted among these are onion and garlic. This present study was therefore conducted to compare the effects of daily administration of garlic and onion extracts on alloxan induced diabetic rat. Diabetes was induced in Female Wister rats weighing 150-200g by intraperitoneal injection of freshly prepared alloxan monohydrate (150 mg/kg body weight).Diabetes was confirmed after seven days in rats showing fasting blood glucose levels ≥ 200mg/dl. The diabetic rats were randomly allocated into three experimental groups which received garlic extract, onion extrac...
Pharmacologyonline, 2010
The effects of the increasing dosages of A. sativum aqueous extracts on alloxan-induced diabetic Rattus novergicus for possible use in the management of diabetes mellitus was investigated. Diabetes mellitus was induced in 54 out of a total of 63 adult Rattus novergicus using 150mg/kg of alloxan monohydrate. Increasing dosages (200, 250 and 300mg/kg) of A. sativum aqueous extracts were given to the diabetic rats for six weeks while the control rats got either normal saline (1ml) or increasing dosages of glibenclamide (2.5, 3.8 and 5.0mg/kg) during the same period. Blood glucose level, total serum lipids and total serum cholesterol were assessed with routine methods. F-LSD was employed to test significant differences (P < 0.05) among treatment means. Increasing dosages of A. sativum aqueous extracts produced a dose-dependent significant (P < 0.05) reductions in the blood glucose levels, total serum lipid and total serum cholesterol when compared with that of the control rats. The most effective percentage reduction in blood glucose level, total serum lipids and cholesterol were observed at 300mg/kg. From the experimental findings, it is possible to conclude that A. sativum studied exhibited promising hypoglycaemic and hypolipidaemic activity in alloxan-induced diabetic rats. It's hypoglycaemic and hypolipidaemic effects could represent a protective mechanism against the development of hyperglycaemia and hyperlipidaemia characteristic of diabetes mellitus.