Retrospective report on the prevalence of bBuruli Ulcer in Imo State, Nigeria (original) (raw)
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Index Cases of Buruli Ulcer Disease in Three States of South-West , Nigeria – A Preliminary Study
2018
Introduction: Buruli ulcer (BU) caused by Mycobacterium ulcerans is a severe, necrotizing disease affecting the skin, subcutaneous adipose tissue and occasionally bones. This neglected tropical infection was regarded as an emerging infectious disease by the World Health Organization (WHO) in 1998. BU, as the third most common mycobacterial disease after tuberculosis and leprosy, has been reported in more than 30 countries worldwide. The disease is characterized by the production of mycolactone which is thought to be responsible for the large ulcers associated with this disease. The mode of transmission is poorly understood but the controversial role of aquatic insects and mosquitoes has been proposed. This study, as a part of an ongoing research project, is aimed at determining the genomic epidemiology of Buruli ulcer disease (BUD) in southwest, Nigeria. Methodology: Community-based sensitization awareness and an active case search involving the identification of suspected cases of ...
Clinical Profile Of Buruli Ulcer Patients In A Referral Hospital In Anambra State, Nigeria
International Journal Of Health & Medical Research
Background: Buruli ulcer is a chronic, debilitating, necrotizing disease of the skin and soft tissue caused by Mycobacterium ulcerans. Early detection and appropriate treatment of the patients are currently the most important measures for preventing the debilitating consequences of the disease. Objective: To assess the clinical profile of Buruli ulcer patients presenting in a referral hospital in Anambra state, Nigeria. Methods: A cross-sectional descriptive study was carried out among a cohort of 39 Buruli ulcer disease patients referred to a referral hospital in Anambra State between July and December 2021. A semi-structured, interviewer-administered questionnaire was used to collect data on the socio-demographic characteristics and the clinical presentation of the patients. Data were analyzed using SPSS version 22; with alpha set at p-value ≤ 0.05. Results: Twenty one (53.8%) of the study participants were males while 18 (46.2%) were females. Their mean age was 28.41±18.668. Acti...
Laboratory confirmation of Buruli ulcer cases in Ghana, 2008-2016
PLOS Neglected Tropical Diseases
Background Buruli ulcer (BU), a necrotizing skin infection caused by Mycobacterium ulcerans is the third most important mycobacterial disease globally after tuberculosis and leprosy in immune competent individuals. This study reports on the retrospective analyses of microbiologically confirmed Buruli ulcer (BU) cases in seventy-five health facilities in Ghana. Method/Principal findings Pathological samples were collected from BU lesions and transported either through courier services or by car directly to the laboratory. Samples were processed and analysed by IS2404 PCR, culture and Ziehl-Neelsen staining for detection of acid-fast bacilli. From 2008 to 2016, we analysed by PCR, 2,287 samples of 2,203 cases from seventy-five health facilities in seven regions
Buruli ulcer in Nigeria: results of a pilot case study in three rural districts
Infectious Diseases of Poverty, 2016
Background: Buruli ulcer (BU), also known as Mycobacterium ulcerans disease, is the third most common mycobacterial disease worldwide. Although BU disease has been diagnosed among Nigerians in neighbouring West African countries, data on the burden of the disease in Nigeria itself are scanty. This study aimed to assess the magnitude and epidemiology of BU in the South South region of Nigeria. Methods: We conducted a cross-sectional survey in the Ogoja territory (comprising 31 communities). We undertook sensitisation programmes centred on BU in 10 of the communities. Participants were asked to identify community members with long-standing ulcers, who were then invited for evaluation. We also contacted traditional healers to refer their clients who had non-healing ulcers. All suspected cases had a full clinical evaluation and laboratory testing. Confirmed cases were given treatment in a referral hospital in the territory. Results: We diagnosed 41 clinical BU cases; 36 (87.8 %) of which were confirmed by quantitative polymerase chain reaction (qPCR). These 36 PCR-confirmed cases were diagnosed in a total population of 192,169 inhabitants. Therefore, the estimated crude prevalence of BU was 18.7 per 100,000 population, varying from 6.0 to 41.4 per 100,000 in the districts surveyed. The majority (66.7 %) of the cases were females. About 92 % of the BU lesions were located on the patients' extremities. No differences were observed between the sexes in terms of the location of the lesions. The age of the patients ranged from four to 60 years, with a median age of 17 years. All 35 (100 %) patients who consented to treatment completed chemotherapy as prescribed. Of the treated cases, 29 (82.9 %) needed and received surgery. All cases healed, but 29 (82.9 %) had some limitations in movement. Healing with limitations in movement occurred in 18/19 (94.7 %) and 8/10 (80.0 %) of patients with lesions >15 cm (Category III) and 6-15 cm in diameter (Category II), respectively. The median duration of treatment was 130 (87-164) days for children and 98 (56-134) days for adults (p = 0.15). Conclusions: In Nigeria, BU is endemic but its severity is underestimated-at least in the study setting. There is a need to identify and map BU endemic regions in Nigeria. A comprehensive BU control programme is also urgently needed.
Buruli ulcer in South Western Nigeria: a retrospective cohort study of patients treated in benin
PLoS neglected tropical diseases, 2015
Nigeria is known to be endemic to Buruli ulcer, but epidemiological data are remarkably rare. Here, we present a large cohort of 127 PCR-confirmed M. ulcerans infection patients coming from Nigeria and treated in a neighbouring country, Benin. Severe lesions and delay of consultation are factors that should encourage establishment of a treatment centre in South Western Nigeria.
Report of a series of 82 cases of Buruli ulcer from Nigeria treated in Benin, from 2006 to 2016
PLoS neglected tropical diseases, 2018
Nigeria is one of the countries endemic for Buruli ulcer (BU) in West Africa but did not have a control programme until recently. As a result, BU patients often access treatment services in neighbouring Benin where dedicated health facilities have been established to provide treatment free of charge for BU patients. This study aimed to describe the epidemiological, clinical, biological and therapeutic characteristics of cases from Nigeria treated in three of the four treatment centers in Benin. A series of 82 BU cases from Nigeria were treated in three centres in Benin during 2006-2016 and are retrospectively described. The majority of these patients came from Ogun and Lagos States which border Benin. Most of the cases were diagnosed with ulcerative lesions (80.5%) and WHO category III lesions (82.9%); 97.5% were healed after a median hospital stay of 46 days (interquartile range [IQR]: 32-176 days). This report adds to the epidemiological understanding of BU in Nigeria in the hope ...
RESEARCH B Buruli Ulcer in Ghana: Results of a National Case Search
2013
A national search for cases of Buruli ulcer in Ghana identified 5,619 patients, with 6,332 clinical lesions at various stages. The overall crude national prevalence rate of active lesions was 20.7 per 100,000, but the rate was 150.8 per 100,000 in the most disease-endemic district. The case search demonstrated widespread disease and gross underreporting compared with the routine reporting system. The epidemiologic information gathered will contribute to the design of control programs for Buruli ulcer. uruli ulcer disease is assuming public health importance in many countries, prompting the establishment of a Global Buruli Ulcer Initiative by the World Health Organization (WHO) in early 1998. Ever since Mycobacterium ulcerans infection was first described in Australia in 1948 (1) and later named Buruli ulcer in Uganda (2), cases have been reported throughout the tropical and subtropical world. In the African WHO region, at least 16 of 46 member countries report cases, especially in W...
Challenges in the Management of Buruli Ulcer in Nigeria -A Case Report and Literature Review
Archives of Medicine and Health Sciences ¦ Volume 11 ¦ Issue 1 ¦ J, 2023
Buruli ulcer (BU) is a disfiguring infective skin lesion caused by Mycobacterium ulcerans. If untreated, BU may lead to extensive soft-tissue loss and other complications. The objective of this study is to highlight the challenges encountered in the diagnosis and management of a patient with BU in our hospital. The patient is a 5-year-old boy who presented with an extensive nonhealing ulcer, knee deformity, and fever. He was initially managed as a case of nonspecific ulcer. A recurrence of the ulcer with loss of part of the skin grafts a week after discharge led to the clinical suspicion of BU which was confirmed using microscopy. In South Western Nigeria, the major constraint in the management of BU includes underdiagnosing of the disease because it is not often screened for due to absence or insufficient standard diagnostic instruments dedicated for that purpose.
2014
Background Buruli ulcer (BU) is a skin disease caused by Mycobacterium ulcerans. Its exact mode of transmission is not known. Previous studies have identified demographic, socio-economic, health and hygiene as well as environment related risk factors. We investigated whether the same factors pertain in Suhum-Kraboa-Coaltar (SKC) and Akuapem South (AS) Districts in Ghana which previously were not endemic for BU. Methods We conducted a case control study. A case of BU was defined as any person aged 2 years or more who resided in study area (SKC or AS District) diagnosed according to the WHO clinical case definition for BU and matched with age- (+/−5 years), gender-, and community controls. A structured questionnaire on host, demographic, environmental, and behavioural factors was administered to participants. Results A total of 113 cases and 113 community controls were interviewed. Multivariate conditional logistic regression analysis identified presence of wetland in the neighborhood...
Journal of Cosmetics, Dermatological Sciences and Applications, 2019
Introduction: The objective of our work was to describe the epidemiological, clinical and biological profile of Buruli ulcer in "Centre de Dépistage et de traitement de l'ulcère de Buruli" (CDTUB) in Allada. Methods: A descriptive and retrospective study focused on new cases of Buruli ulcer received in the CDTUB of Allada from 2010 to 2014. The diagnosis of Buruli ulcer was based on epidemiological, clinical and biological arguments. Results: Over 5 years, 274 new cases of Buruli ulcer have been diagnosed. The average age of the patients was 12 years and the sex ratio was 0.8. The average time to first consultation was 45 days. Clinically, 61% had a joint functional limitation. Lesions were ulcerated in 69% of cases, category I (26%), category II (53%), category III (21%) and were present on the lower limbs in 57% of cases. Microscopy was positive in 65.7% of cases and PCR in 78.1% of cases. Microscopy supplemented by PCR confirmed the diagnosis in 81% of cases. Conclusion: The epidemiological, clinical and biological profile of Buruli ulcer in Allada was characterized by a predominant disease in children, a predominance of ulce