Sodium channel mutations in paramyotonia congenita uncouple inactivation from activation (original) (raw)

Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita

robert barchi

Neuron, 1992

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Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro

robert barchi

Proceedings of the National Academy of Sciences of the United States of America, 1994

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Differential effects of paramyotonia congenita mutations F1473S and F1705I on sodium channel gating

James Groome

Channels, 2008

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Sodium channel mutations in paramyotonia congenita and hyperkalemic periodic paralysis

Jerry Mendell

Annals of Neurology, 2004

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Fast- and slow-gating modes of the sodium channel are altered by a paramyotonia congenita-linked mutation

M. Nizzari

Journal of bioenergetics and biomembranes, 1998

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Human Na+ channel fast and slow inactivation in paramyotonia congenita mutants expressed in Xenopus laevis oocytes

Janet Richmond

The Journal of physiology, 1997

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Mutation in the S4 segment of the adult skeletal sodium channel gene in an Italian Paramyotonia Congenita (PC) family

G. Meola

The Italian Journal of Neurological Sciences, 1994

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Paramyotonia congenita mutations reveal different roles for segments S3 and S4 of domain D4 in hSkM1 sodium channel gating

robert barchi

The Journal of General Physiology, 1996

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Kinetic Alterations in Resurgent Sodium Currents of Mutant Nav1.4 Channel in Two Patients Affected by Paramyotonia Congenita

Chiung-Wei Huang

Biology

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Mutant channels contribute <50% to Na+ current in paramyotonia congenita muscle

Nenad Mitrovic

Brain, 1999

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Mechanisms of cold sensitivity of paramyotonia congenita mutation R1448H and overlap syndrome mutation M1360V

Nenad Mitrovic

The Journal of Physiology, 2003

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Effects of temperature and mexiletine on the F1473S Na + channel mutation causing paramyotonia congenita

Richard Fleischhauer

Pfl�gers Archiv European Journal of Physiology, 1998

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A novel sodium channel mutation causing a hyperkalemic paralytic and paramyotonic syndrome with variable clinical expressivity

Nenad Mitrovic

Neurology, 1997

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Paramyotonia congenita and hyperkalemic periodic paralysis are linked to the adult muscle sodium channel gene

robert barchi

Annals of Neurology, 1991

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Structure, function and expression of voltage-dependent sodium channels

robert barchi

Molecular Neurobiology, 1993

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Paramyotonia congenita: From clinical diagnosis to in silico protein modeling analysis

Dian Kesumapramudya

Pediatrics International, 2012

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Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family

David Hillis

Molecular Biology and Evolution, 2008

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Conus geographus toxins that discriminate between neuronal and muscle sodium channels

Baldomero Olivera

Journal of Biological Chemistry, 1985

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Functional characterization and cold sensitivity of T1313A, a new mutation of the skeletal muscle sodium channel causing paramyotonia congenita in humans

Magali Bouhours

The Journal of …, 2004

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Gene Duplications and Evolution of Vertebrate Voltage-Gated Sodium Channels

Manda Jost

Journal of Molecular Evolution, 2006

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A sodium channel pore mutation causing Brugada syndrome

Samuel Dudley

Heart Rhythm, 2007

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Changes in Resurgent Sodium Current Contribute to the Hyperexcitability of Muscles in Patients with Paramyotonia Congenita

Ming-Jen Lee

Biomedicines

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Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker

Lawrence Hayward

The Journal of General Physiology

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Defective Gating and Proteostasis of Human ClC-1 Chloride Channel: Molecular Pathophysiology of Myotonia Congenita

Chung-Jiuan Jeng

Frontiers in Neurology, 2020

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A gating model for wildtype and R1448H Nav1.4 channels in paramyotonia

Frank Lehmann-Horn

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases, 2014

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Sodium Channel Myotonia Due to Novel Mutations in Domain I of Nav1.4

Marzia Lecchi

Frontiers in Neurology

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Different effects of mexiletine on two mutant sodium channels causing paramyotonia congenita and hyperkalemic periodic paralysis

Nenad Mitrovic

Neuromuscular Disorders, 2000

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Myopathic mutations affect differently the inactivation of the two gating modes of sodium channels

M. Nizzari

Journal of bioenergetics and biomembranes, 1999

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Tenascin-R Is a Functional Modulator of Sodium Channel beta Subunits

Melitta Schachner

Journal of Biological Chemistry, 1999

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A novel muscle sodium channel mutation causes painful congenital myotonia

Karen Sloan-Brown

Annals of neurology, 1997

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Neurotrophic control of channel properties at neuromuscular synapses of rat muscle

bert sakmann

The Journal of Physiology, 1983

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A SCN4A mutation causing paramyotonia congenita

Samuel Pascual

Neuromuscular Disorders, 2017

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Primary structure of the adult human skeletal muscle voltage-dependent sodium channel

robert barchi

Annals of Neurology, 1992

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Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels

Daisuke Kohda

Journal of Biological Chemistry, 1991

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Linkage data suggesting allelic heterogeneity for paramyotonia congenita and hyperkalemic periodic paralysis on chromosome 17

Frank Lehmann-Horn

Human Genetics, 1991

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