Interleukin-5, a therapeutic target in allergic inflammation (original) (raw)

Interleukin-5 (IL-5) is a cytokine pivotal to eosinophil life cycle and function, making it a significant therapeutic target in allergic inflammation, particularly in asthma. The introduction establishes a comprehensive overview of the cellular mechanisms underpinning allergic responses, highlighting the central roles of mast cells and T helper 2 (TH2) cells. Clinical and animal model studies demonstrate a strong association between IL-5 levels and eosinophilic inflammation in asthma. Emerging therapeutic strategies involving anti-IL-5 monoclonal antibodies show promise; however, alternative delivery methods and the exploration of other relevant molecular targets are suggested for optimal efficacy.