Comparative Evaluation of Two Remineralizing Agents on Artificial Carious Lesion Using DIAGNOdent (original) (raw)
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Journal of Conservative Dentistry, 2013
The aim of this study was to evaluate the remineralizing potential of three different remineralizing agents (GC tooth Mousse, Clinpro tooth crθme and SHY-NM) on demineralized tooth surfaces using micro CT and microhardness. Forty five freshly extracted mandibular premolars were collected and enamel specimens were prepared. The samples were assigned to three groups with fifteen specimens in each group. The specimens were then demineralized using McInne's demineralizing solution in two cycles. After that, remineralization was carried out in two cycles for 30 days using Casein phosphopeptide - Amorphous calcium phosphate (CPP - ACP), 0.21% sodium fluoride - Tricalcium phosphate (f-TCP) and Calcium Sodium Phosphosilicate (CSP) containing tooth pastes for groups I, II, III respectively. The specimens were evaluated for Linear attenuation co-efficient using micro CT (Scanco™) and Vicker's Micro Hardness (Schimadzu™) testing at different time periods. The results were tabulated and statistically analysed. It was observed that all the three remineralizing agents used in the study significantly increased the Linear Attenuation Co-efficient and Vicker's hardness number values of the enamel specimens following 15 days and 30 days application. CPP - ACP showed the better remineralizing potential than the other two agents and there was no statistical significant difference between f-TCP and CSP groups.
Journal of Advanced Oral Research, 2020
Aim: To analyze the remineralization efficacy of casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) and 8% arginine on artificial early enamel lesions on primary teeth enamel samples. Materials and Methods: In this in vitro study, artificial enamel lesions were created in 120 primary teeth. Teeth were randomly divided into 5 groups: group C: CPP–ACP paste; group CF: CPP–ACPF paste with 900 ppm flour; group A: paste with 8% arginine; group K+: 500 ppm NaF as a positive control; and group K–: deionized water as a negative control. After 4 weeks of the remineralization process, the effect of remineralization on samples of agents used the microhardness, atomic force microscope, and scanning electron microscope analyses. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS version 20.0, SPSS Inc., Chicago, IL, USA). ANOVA and Tukey Post-Hoc multiple comparison test were applied ( p < .05). Results: Increasing percentage values of the microhard...
International Journal of Biomedical and Advance Research, 2013
Aim: Comparative evaluation of the efficacy of CPP-ACPF and Sodium fluoride with tri-calcium phosphate on enamel remineralisation using the Diagnodent. Materials & Method: Thirty extracted human premolars were selected and divided into three groups of 10 teeth each: A (artificial saliva), B (CPP-ACPF), C (Sodium fluoride with tri-calcium phosphate-Clinpro 5000). All the samples were assessed using DIAGNOdent at the baseline and after demineralization and remineralisation after 7 days. Result: Statistical analysis showed that group B (CPP-ACPF) and group C (Clinpro 5000) had significantly higher amount of remineralisation than group A (artificial saliva). Conclusion: All the three groups showed a statistically significant amount of remineralization.However, Clinpro 5000 showed marginally more amount of remineralisation than CPP-ACPF.
Journal of Applied Oral Science, 2019
The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion Objective: The aim of this in vitro study was to determine the effects of remineralization promoting agents containing casein phosphopeptidestabilized amorphous calcium phosphate (CPP-ACP), or CPP-ACP in combination with fluoride (CPP-ACPF) on artificial white spot lesions (WSLs) after 6 and 12 weeks. Methodology: White spot lesions were created on 123 sectioned premolars (246 specimens) with a demineralization solution during a 96 hours pH-cycling regime. Two experimental groups were created: a CPP-ACP group (Tooth Mousse TM), and a CPP-ACPF group (Mi Paste Plus TM). Additionally, two control groups were created, one using only a conventional toothpaste (1450 ppm fluoride) and another one without any working agents. All teeth were also daily brushed with the conventional toothpaste except the second control group. Tooth Mousse TM and Mi Paste Plus TM were applied for 180 seconds every day. The volume of demineralization was measured with transverse microradiography. Six lesion characteristics regarding the lesion depth and mineral content of WSLs were also determined. Results: The application of CPP-ACP and CPP-ACPF had a significant regenerative effect on the WSLs. Compared to Control group 1 and 2 the volume of demineralization after 6 weeks decreased significantly for CPP-ACP (respectively p<0.001 and p<0.001) and CPP-ACPF (respectively p=0.001 and p=0.003). The same trend was observed after 12 weeks. For the CPP-ACPF group, WSL dimensions decreased significantly between 6 and 12 weeks follow-up (p=0.012). The lesion depth reduced significantly after application of CPP-ACP and CPP-ACPF but increased significantly in the Control groups. Mineral content increased for CPP-ACP and CPP-ACPF after an application period of 12 weeks, but this was only significant for CPP-ACP. Conclusions: Long-term use of CPP-ACP and CPP-ACPF in combination with a conventional tooth paste shows beneficial effects in the recovery of in vitro subsurface caries lesions.
2018
Aim and Objectives: potential of three different dentifrices with different composition (fluoro calcium phosphosilicate, nano-hydroxy apatite, calcium sucrose phosphate) on artificially induced car through scanning electron microscopy and quantitative assessment by energy dispersive X spectroscopy. impacted third molars with intact surfaces divided demineralization was carried out, followed by remineralization using dentifrice slurry as per the group allocation. After 10 days period the entire test groups were evaluated with HRSEM and quantitative assessment by using one way ANOVA, student’s t test and tukey’s multiple comparison tests.p considered to be significant. insignificantly different from each other but highlights the concept of biomimetic bioactive glass as an effective remineralizing agent. treatment on incipient carious lesion by re
Remineralizing potential of CPP-ACP crèmes with and without fluoride in artificial enamel lesions
Australian dental journal, 2015
This study evaluated the effect of pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) with and without fluoride on enamel demineralization. Human enamel blocks were used and after incipient-caries-like lesions were formed, they were assigned to four groups: G1: saliva; G2: MI Paste (Recaldent(™) ); G3: MI Paste Plus (Recaldent(™) 900 ppm as NaF), and G4: Crest(™) (1.100 ppm as NaF). The specimens were soaked in demineralizing solution for 6 hours and remineralized in artificial saliva for 18 hours alternatively for 10 days. The dentifrice was prepared with deionized water in a 1:3 proportion (w/w) or applied undiluted in the case of the CPP-ACP formula. Demineralized enamel changes were analyzed by surface microhardness (SMH), 3D- profilometry and SEM. Data were analyzed by nonparametric Kruskal-Wallis and Mann Whitney tests comparisons and one-way ANOVA and Tukey's HSD post hoc test (α = 0.05). The SMH values observed in G2 (47.8±28.5) and G3 (53.6±27...
International Journal of Clinical Pediatric Dentistry, 2022
The oral cavity is a constant interplay of demineralization and remineralization. 1 There is a is continuous exchange of ions between dental hard tissues and oral environment. 2 The hardness of tooth depends on the proportion between demineralization and remineralization. 1. Imbalance in this exchange of ions leading to shift toward more demineralization lead to white spot lesion. 3 These white spot lesions are initial sign of caries process. 4 If not treated lesions it may progress to frank cavitation which may require surgical management. 5 However, if intervention is done at the initial stage remineralization of white spot lesion is possible. This forms the basis of Minimal Intervention Dentistry. 1 The clinically proven anticaries benefits of fluoride have provided a solid benchmark for new formulations or prospective technologies. 6,7 Significant research in the development new casein phosphopeptide (CPP) sequence is going on. 7 Increased calcium and phosphate concentrations in the oral environment by the use of tri-calcium phosphate agent can also increase remineralization of tooth. 8 In this study, demineralization and remineralization was analyzed by using surface microhardness measurements. The aim of the present
Remineralization of Tooth: A Literature Review
Journal of Pharmaceutical Research International
Non-cavitated carious lesions are managed non-invasively through remineralization in an attempt to prevent disease progression, and to improve strength, esthetics, and function of teeth in the modern dentistry. The emphasis presently is being given to new technologies which suggest the changes in the understanding of dental caries, and most of them gave significant positive outcome regarding remineralisation when used clinically. The aim of this review article is to put a light on various available remineralizing agents along with some recently introduced agents.
Journal of clinical and diagnostic research : JCDR, 2017
Decades of research has helped to increase our knowledge of dental caries and reduce its prevalence. However, according to World Oral Health report, dental caries still remains a major dental disease. Fluoride therapy has been utilised in a big way to halt caries progression, but has been met with limitations. This has paved the way for the development of newer preventive agents that can function as an adjunct to fluoride or independent of it. The purpose of the present study was to evaluate the ability of Casein Phosphopeptide-Amorphous Calcium Phosphate Fluoride (CPP ACPF), Bioactive Glass (BAG), fluoride enhanced Hydroxyapatite (HA) gel and self-assembling peptide P11-4 to remineralise artificial carious lesions in enamel in vitro using a 30 day pH cycling model through surface microhardness analysis and SEM. Sixty enamel samples were divided into five groups of 12 samples each. The control Group A consisted of intact enamel samples, Group B: CPP-ACPF (Tooth Mousse Plus), Group C...