Results of multidisciplinary therapy of squamous cell carcinoma of the buccal mucosa at Srinagarind Hospital, Thailand (original) (raw)
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Squamous cell carcinoma of the buccal mucosa: Outcomes of Treatment in the modern era
The Laryngoscope, 2012
Objectives/Hypothesis: The objective of this study was to analyze the patterns of failure and to determine clinical and pathologic factors predictive of recurrence and survival of patients treated for squamous cell carcinoma of the buccal mucosa at Princess Margaret Hospital. Study Design: Retrospective chart review. Methods: A retrospective chart review of patients treated for buccal carcinoma between 1994 and 2004 was performed. Seventy patients with newly diagnosed and previously untreated squamous cell carcinoma of the buccal mucosa were included. Demographic, clinical, and pathological parameters were identified and correlated with outcomes. Results: The patient cohort consisted of 33 males and 37 females. Most patients presented with early-stage local disease (T1-T2). Surgery was the primary treatment in 61 patients. Twenty-three patients were treated with postoperative radiotherapy. Median follow-up was 3.3 years. The 5-year local, regional, and overall control rates were 57.5%, 83.5%, and 50%, respectively. The 5-year overall survival rate was 69%. The 5-year disease-specific and recurrence-free survival rates were 76.4% and 46%, respectively. The only significant predictors of survival were the nodal status and extranodal extension. Conclusions: Carcinoma of the buccal mucosa is an aggressive disease, characterized by a high rate of locoregional failure. Transoral wide excision is an adequate treatment for early-stage lesions; however, a combined approach and an elective neck dissection should be considered in advanced lesions.
Squamous cell carcinoma of the buccal mucosa☆☆☆
Otolaryngology - Head and Neck Surgery, 1999
The purpose of this study was to establish treatment criteria for patients with early-stage squamous cell carcinoma of the buccal mucosa. Thirty-one patients were analyzed in a retrospective fashion. Distribution of patients according to tumor stage was relatively even. Within 5 years recurrent disease developed in nearly 80% of evaluable patients. There was a 100% overall incidence of local disease recurrence for patients with stage I and II tumors treated with wide local excision alone and followed up for more than 2 years. On the basis of these data, we conclude that wide local excision for early-stage buccal carcinoma is associated with a high local failure rate. Possible causes for failure and alternative treatment approaches are discussed.
Post-operative radiotherapy in carcinoma of buccal mucosa, a prospective randomized trial
European Journal of Surgical Oncology (EJSO), 1996
Squamous cell carcinoma of the buccal mucosa is a common cancer in India. We are referred a large number of locally advanced lesions where curative surgery is still possible. The objective of this study is to determine the role of postoperative radiotherapy in enhancing disease-free survival. Patients with stages lll and IV cancer of the buccal mucosa potentially curable by surgery were randomized to surgery only or post-operative radiotherapy. Patients were followed up for 3 years. The clinico-pathological features in both arms were comparable. Disease-free survival at the end of the study was found to be 38% and 68% (P<0.005) respectively. Post-operative radiotherapy was thus seen to improve disease-free survival in squamous cell carcinoma of the buccal mucosa.
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2003
Background.Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC.Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC.Methods.We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded.We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded.Results.Patients with T1- or T2-sized tumors had only a 78% and 66% 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p < .05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful.Patients with T1- or T2-sized tumors had only a 78% and 66% 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p < .05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful.Conclusions.SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites. © 2003 Wiley Periodicals, Inc. Head Neck 25: 267–273, 2003SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites. © 2003 Wiley Periodicals, Inc. Head Neck 25: 267–273, 2003
Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment
Head & Neck, 2006
Background. In our clinical practice, we have observed a high incidence of locoregional failure in squamous cell carcinoma (SCC) of the buccal mucosa. We analyze our treatment results of this cancer and compare these results with those in the literature. We intend to define the pattern and incidence of failure of buccal cancer and provide information for the design of a better multimodality treatment.
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
We report a case of advanced case of right sided buccal mucosa deemed inoperable achieving long term cure with a combination of interstitial brachytherapy and concurrent chemoradiotherapy (CRT) followed by salvage surgery for small recurrence. The patients were considered for upfront double plane 12 catheter implant to a dose of 25 Gy in 8 fractions at the rate of 3.125 Gy per fraction. Two fractions were delivered in a day at least 6 hours apart. Thereafter patient was subjected to CRT to a dose of 40 Gy in 20 fractions. At follow up there was complete resolution of disease barring a small induration raw area at angle of mouth, which was successfully managed by salvage surgery. Patient is now on regular follow up for 18 months from completion of treatment and is disease free for 1 year.
A buccal mucosa carcinoma treated with high dose rate brachytherapy
Journal of applied clinical medical physics / American College of Medical Physics, 2005
This manuscript presents a case of early stage squamous cell carcinoma of the left buccal mucosa treated with intensity-modulated radiation therapy (IMRT) followed by a high-dose rate (HDR) brachytherapy boost. With limited literature available on HDR mold (stent) radiotherapy for oral cancer, a discussion on the issues encountered during treatment planning and delivery may prove to be insightful for facilities faced with a similar challenge.
Surgical Resection of Cancer of the Buccal Mucosa
2017
The buccal mucosa lines the inner aspect of the cheek and the lip. It is limited superiorly and inferiorly by its attachments to the alveoli. It extends posteriorly to the retromolar trigone. Deep to the buccal mucosa is the buccinator muscle (Figures 2, 3). Immediately lateral to the buccinator muscle is the facial artery and the buccal artery and the vascular plexus that the buccinator myomucosal flap is based on. (See chapter: Buccinator myomucosal flap)
Journal of Otolaryngology - Head & Neck Surgery, 2019
Objective To systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy. Data sources Ovid MedLine, EMBASE, Google Scholar, PubMed. Review methods The primary purpose was to perform a systematic review to determine the published literature comparing oncologic outcomes of patients with early stage (Stages I&II) buccal mucosal squamous cell carcinoma, treated with surgical resection alone versus surgery plus adjuvant radiation therapy. Oncologic outcomes of interest were overall survival, locoregional recurrence, and disease specific survival. The secondary aim was to perform a meta-analysis to quantitively compare and summarize the data on oncologic outcomes between treatments. Results A total of 1457 studies were screened and five retrospective cohort studies (n = 733 patients) were eligible for quantitative analysis. Overall study quality was modera...