Efficacy of nano encapsulated herbal extracts in the treatment of induced wounds in animal models: a systematic review protocol (original) (raw)
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As we know traditional herbal medicines have been widely used around the world since the ancient times but most of the traditional herbal drugs and their extracts despite of their impressive in-vitro findings demonstrate less or negligible in-vivo activity due to their poor lipid solubility or improper molecular size, resulting in poor absorption and hence poor bioavailability. Poor bioavailability increases system clearance requiring repeated administration or higher dose, which makes the drug as a poor candidate for therapeutic use. Nanotechnology is bringing a new aspect in the field of scientific and technology and its application in healthcare that lead to development of novel drug delivery systems. Drug delivery system for herbal formulations based on applicative, nanotechnology has a potential future for enhancing the product efficacy and overcoming problem of slow or less absorption; associated with the herbal drugs. The marketed nano herbal products are Aegis. Lifepak Nano,...
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2023
Wound healing is well-organized but a cascade of complex biochemical and cellular process to revive the normal morphology and functioning of skin. There are several plant-derived active biocomponents which are known to have their applications in wound healing due their negligible side effects. Present wound healing therapies, techniques and products are not that efficient to recover the wounds without affecting skin morphology and function. The approach/technique is considered to be the ideal if it cures/heals the wound without affecting the normal functioning of the skin, without scar formation, inhibit bacterial infection, speeds up the healing mechanism and keep the wound moisturized. Nanotechnologicalbased approaches are developed to increase the efficacy of the drug as well as herbal/plant-based organic products through direct delivery to the target, enhanced bioavailability and biocompatibility, controlled release of drug and enhanced solubility. The following literature review is about the different plant-based nanomaterials, their role in wound healing and delivery of herbal drugs to site of infection. For this purpose, profound research has been done to discover how and why natural product-based nanomaterials are being used to cure wound. This review will tell you the mechanism of action of plant-based nanomaterials to heal the wound and the elimination of challenges which are usually faced during the wound healing process such as bacterial infection, biofilm formation that leads towards chronic wound. As compared to the classical therapies of wound healing, nanotechnological based methods keep the wound moisturized. Various plant-based nano-formulations show remarkable activity in wound healing and management and are considered to be the future of pharmaceuticals.
Herbal Nanoparticles: A Commitment towards Contemporary Approach
Indian Journal of Pharmaceutical Education and Research, 2023
Herbal medicines have been used extensively since ancient times in almost every region of the world and are regarded by patients and doctors as having the best therapeutic value or effect because they have very few or lesser side effects than synthetic medications. In order to deliver the components over time, avoid the need for repeated dose administration, and improve patient compliance, phytotherapeutics requires some scientific approaches. The current article discusses the various kinds of nanoparticles, nano drug delivery methods, agricultural applications, advantages, properties, disadvantages, and methods of preparing nano herbal medicines. Nanoparticle applications in a variety of fields, including cosmetics, plant protection, crop enhancement, wastewater treatment, and treatment of several chronic diseases, are also discussed. The review utilizes papers obtained from various databases like Google scholar, PubMed, Science Direct and the articles from 1976 to 2022 are incorporated. The establishment of Novel or Newer Drug Delivery Systems could be used to obtain all of the herbal constituents (NDDSs). The novel or newer drug delivery system not only aids in reducing the number of times the drug must be administered to overcome non-compliance, but also significantly boosts therapeutic value by boosting bioavailability and limiting toxicity. Herbal nanoscale drug delivery systems or plant derived medication has a promising future in overcoming problems and enhancing activities associated with plant derived medicines. As a result, nano-formulations are frequently being used for more precise and controlled drug delivery to target tissues. Nanostructured systems can enhance the effects of plant extracts, lowering dosage requirements, minimising side effects, and increasing their activity.
Plants
In Africa, medicinal plants have been traditionally used as a source of medicine for centuries. To date, African medicinal plants continue to play a significant role in the treatment of wounds. Chronic wounds are associated with severe healthcare and socio-economic burdens despite the use of conventional therapies. Emergence of novel wound healing strategies using medicinal plants in conjunction with nanotechnology has the potential to develop efficacious wound healing therapeutics with enhanced wound repair mechanisms. This review identified African medicinal plants and biogenic nanoparticles used to promote wound healing through various mechanisms including improved wound contraction and epithelialization as well as antibacterial, antioxidant and anti-inflammatory activities. To achieve this, electronic databases such as PubMed, Scifinder® and Google Scholar were used to search for medicinal plants used by the African populace that were scientifically evaluated for their wound hea...
Journal of Experimental Biology and Agricultural Sciences
Herbal remedies have been extensively used since times immemorial throughout the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Commonly, the herbal medicines are available in the form of crude extracts prepared in different solvent systems which might not only need large dose administration but also could be less effective in the form of conventional formulations. Moreover, available phytoformulations do not have the ability for specific tissue target delivery in case of different chronic diseases. Oral administration of these herbal formulations is subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption and bioavailability. With the advancements in biotechnology, genomics, and combinatorial chemistry, new, more potent and specific drug delivery systems have been envisaged during the last few decades. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using-Nano Delivery Systems‖ (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient's compliance. Nano herbal medicines can be used to target them to the specific site in the body which improves their selectivity, solubility, delivery, safety, effectiveness and thus reduces the need for
Utilization of Haramounting Nano- Herbal(Rhodomyrtustomentosa) In Burn Wound Healing II in Rats
Background:There are reports that haramounting has antioxidant and antibacterial properties. therefore it can be developed as an ingredient in accelerating wound healing. Because the wound will cause increased oxidants and invite the presence of bacteria or other microorganisms to grow and will certainly inhibit the wound healing process. Materials and Methods: This study uses a true experiment method with a completely randomized design, four treatments (negative control, positive control, bioplacenton, haramountingnano-herbal), and observation time of burns healing (0 days, 4, 8, 12 and 16 days) with each field four replications. Results: It was found that haramountingnano-herbal was very effective in healing second degree burns in rats for 16 days without leaving Gram (-) and Gram (+) (effective antibacterial) bacteria. Bioplacenton is effective in healing second-degree burns in rats for 16 days, but the antibacterial properties still leave Gram (+) bacteria. Conclusion:The effectiveness of healing degree II burns in mice is better in haramountingnano-herbal than bioplasenton as well as its antibacterial properties.
Advanced Methodologies and Techniques for Assessing Nanomaterial Toxicity
Progress toward Nanomedicine, Second Edition, 2014
Herbal ingredients and the combination of several species of plants, account for the different therapeutic and healing effects observed in the "complementary" or "alternative" medicine. The practice of herbal medicine is responsible for extense human knowledge that has developed over time in various cultures, worldwide. Cosmetics or nutracosmetics may cause adverse reactions in the skin, specially when there is a lack of cosmetic vigilance management. It is important to promote, in a relatively permissive regulatory environment, conscious efforts on the part of health professionals, to evaluate the outcomes and validate their pharmacological and cosmetic use. Traditional knowledge about the use of some herbs should be reevaluated and scientific basis should be considered. It is important to conduct a complete scientific research for validating herbal therapeutics and optimizing safety. Scientific toxicological research, using proper models, must continue to prove quality, efficacy, pharmacokinetics and pharmacodynamics interactions with other substances, and safety. Mechanisms of actions, as well as factors affecting toxicity should be studied, revised and taken in account to prevent adverse reactions, when using complementary or alternative medicine.