The Effects of Nigella Sativa Seed Extract on Bone Healing in an Experimental Model (original) (raw)
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Asian Journal of Pharmaceutical and Clinical Research, 2017
Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa(NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review toevaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or thismatter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, andCINAHIL. Terms searched included “Nigella sativa, black seed, TQ, osteoporosis, bone healing.” Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as ...
Nigella sativa (Black seeds) has been recognized as one of the most popular herbs in many parts of the world for centuries. It was used in the world as folk medicine to cure different kinds of diseases. This plant has been considered as one of the main sources of nutrition and healthcare for humans as well as animals. It has been perceived as Kalonji; it is a southwest Asian plant that flowers annually. The seeds and oil of this plant have been used in food; in addition, it has a long history in the making of medicines. In addition to its being a model plant for better realization of gene and chromosome relationship, the plant species is also significant cytogenetically. Plant based system has not been absorbed fully for human health care despite the remarkable advancements in the field of pharmacology. Cumin, as one of the medicinal plants gifted to humans by nature, has a number of potential uses. It has been proved to be a useful herbal medicines that can be used for human health and therefore has been extensively studied and investigated to further discover the advantages of this plant.
The Various Effects of Nigella Sativa on Multiple Body Systems in Human and Animals
Zenodo (CERN European Organization for Nuclear Research), 2016
Nigella sativa (Black seeds) has been recognized as one of the most popular herbs in many parts of the world for centuries. It was used in the world as folk medicine to cure different kinds of diseases. This plant has been considered as one of the main sources of nutrition and healthcare for humans as well as animals. It has been perceived as Kalonji; it is a southwest Asian plant that flowers annually. The seeds and oil of this plant have been used in food; in addition, it has a long history in the making of medicines. In addition to its being a model plant for better realization of gene and chromosome relationship, the plant species is also significant cytogenetically. Plant based system has not been absorbed fully for human health care despite the remarkable advancements in the field of pharmacology. Cumin, as one of the medicinal plants gifted to humans by nature, has a number of potential uses. It has been proved to be a useful herbal medicines that can be used for human health and therefore has been extensively studied and investigated to further discover the advantages of this plant.
Effect of Black Seed (Nigella Sativa) on Compact Bone of Streptozotocin Induced Diabetic Rats
The Egyptian Journal of Histology, 2010
Introduction: Diabetes mellitus is a pandemic metabolic disease having several bone complications. Nigella sativa (NS) might have a role similar to insulin in diabetes and might be useful in treatment of diabetic osteoporosis. Aim of the Work: This work aimed to clarify changes of the compact bone of streptozotocin induced diabetic adult male rats and the possible role of nigella sativa. Materials and Methods: Forty adult male rats were used. They were divided into four groups: Control; NS treated; diabetic and diabetic with NS. On sacrifice, blood samples were drawn to determine serum alkaline phosphatase (ALP) level. Both femora of each animal were processed for radiological, histological, immunohistochemical and morphometrical studies. Results: Diabetic rats showed highly significant decrease in body weight and serum ALP level. Radiologically, femora of diabetic rats showed decreased bone density, bone softening and cortical thinning. Histologically, there was degeneration of osteoblasts and osteocytes, multiple osteoporotic cavities, decreased collagen fibers and irregularity of bone surfaces. Morphometrically, there was a highly significant decrease in osteoblast number. Immunohistchemically, there was a negative expression of osteopontin protein in bone matrix. Treatment of diabetic rats with NS resulted in improvement of body weight, biochemical, radiographical, histological, morphometrical and immunohistochemical pictures. Conclusion: Diabetes could lead to osteoporosis which might increase incidence of bone fractures. NS which is a cheap, available natural plant could ameliorate diabetic changes of bone. So it could be considered as a curative measure of diabetic osteoporosis.
A Review on the Cosmeceutical and External Applications of Nigella sativa
It is estimated by the World Health Organization (WHO) that most of the world's population depends on herbal medicine for their health care. Nigella sativa (N. sativa), also known as black-caraway and as " Kalonji, " is a well-known seed all over the world. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Due to these numerous important ingredients it was found that it affects different areas of our body and has many pharmacological effects as antibacterial, antiviral, anti-inflammatory, and wound healing effect and also for acne vulgaris, skin cancer, pigmentation, and many cosmeceutical applications. Based on the folklore usage of N. sativa seeds and oil, they are used in various systems of food and medicines. The aim of this article is to provide a detailed survey of the literature of cosmeceutical and external applications of N. sativa which is expected to stimulate further studies on this subject.
Nigella sativa: A Potential Antiosteoporotic Agent
Evidence-Based Complementary and Alternative Medicine, 2012
Nigella sativa seeds (NS) has been used traditionally for various illnesses. The most abundant and active component of NS is thymoquinone (TQ). Animal studies have shown that NS and TQ may be used for the treatment of diabetes-induced osteoporosis and for the promotion of fracture healing. The mechanism involved is unclear, but it was postulated that the antioxidative, and anti-inflammatory activities may play some roles in the treatment of osteoporosis as this bone disease has been linked to oxidative stress and inflammation. This paper highlights studies on the antiosteoporotic effects of NS and TQ, the mechanisms behind these effects and their safety profiles. NS and TQ were shown to inhibit inflammatory cytokines such as interleukin-1 and 6 and the transcription factor, nuclear factor κB. NS and TQ were found to be safe at the current dosage for supplementation in human with precautions in children and pregnant women. Both NS and TQ have shown potential as antiosteoporotic agent but more animal and clinical studies are required to further assess their antiosteoporotic efficacies.
2010
Background and the purpose of the study: Experimental studies have shown that Ns (Nigella sativa) seeds oil can increase bone formation and may have anabolic effects on bone loss. This study was conducted to investigate the beneficial impacts of the oil of Black seeds on bone turnover in osteoporotic postmenopausal women. Materials and methods: A placebo controlled pilot study was carried out on 15 postmenopausal osteoporotic women of 48-74 years old. In addition to Calcium-D supplements (2 tablets per day) all participants were randomly received Ns extract (3ml, 0.05 ml/kg/day p .o.) or placebo for 3 months. In all subjects hematological tests were performed and hepatic enzymes, BUN, Cr, Ca, P and plasma bone formation and resorption markers including osteocalcin, bone alkaline phosphatase (Bone-ALP) and carboxy terminal cross linked telopeptide (CTX) was determined before and after 12 weeks of treatment. Results: Twelve participants completed the entire 12 weeks study course of which 5 and 7 women were belonged to Ns and placebo groups respectively. Women in placebo group were significantly older than women in Ns group. There were not significant differences between BMIs, BMD results and plasma levels of bone marker in two groups at the baseline and plasma levels of bone markers between Ns and placebo group at the end of 12 weeks. Alterations from baseline in bone markers levels did not differ significantly between two groups. We did not observe any side effects due to Ns therapy. Conclusion: In this pilot study similar to the previous trial, we failed to show beneficial impact of Ns extract administration for a short time on bone turnover so we don't suggest it for medicinal application in the osteoporosis condition. Long time duration studies with larger sample size and usage of a more tolerable dosage forms of Black seeds oil should be emphasized for further clarification of its useful anabolic effects on bone metabolism.
Indian journal of Unani medicine, 2021
Background: Nigella sativa L. or black cumin, belong to the family Ranunculaceae, has long been used traditionally, for food purposes and in traditional Unani medicines and is a native of the Arabian Gulf region, East Asia, Africa and Europe. It is a rich medicinal plant in bioactive compounds. Aim of the study: The aim of this review is to develop an overview of black cumin seed in the context of the status traditional Unani medicine ideology with the incorporation of ethno pharmacological uses, chemical compositions, pharmacological activities, safety profile with evidence-based approach. Materials and Methods: Information on Nigella sativa L. was obtained from published materials, including medicinal plants monographs, ancient and modern recorded classical texts, Unani pharmacopoeias and electronic databases such as Pub Med, Web of Science, Science Direct and Google Scholar. Results: Black cumin seed has been used in Unani traditional medical systems throughout history. The presence of thymoquinone is mainly responsible for its most of the medicinal properties. Moreover, the presence of vitamins, myristic acid, proteins, fats, fiber, amino acids and some trace metals are also reported in the seeds particularly used as a nutraceutical. Numerous in vivo and in vitro studies on pharmacological effects of Nigella sativa L. viz. antioxidant, anticancer, immuno-modulatory, antimicrobial, neuroprotective, cardio protective, gastro protective, anti-hypertensive, nephroprotective, hepatoprotectiv e and anti-diabetic properties demonstrated positive effect against diabetes, hypertension, hypercholesterolemia, bronchitis, asthma, rheumatism, back pain, cancer, gastrointestinal disorders, and eczema etc. Conclusion: Contemporary researches on Nigella sativa L. support the views of Unani physicians for its use as a food and medicinal herb. Black cumin-based potential therapeutic agents need to be applied for a variety of diseases and the formulation of accepted functional foods with the aim to promote optimum health and lessen the risk of chronic diseases.
SciDoc Publishers, 2021
Objective: The aim of this study is to evaluate the histological pulp response following direct pulp capping with Nigella Sativa paste (NS)in comparison to calcium hydroxide(CH) in rabbits' teeth. Methodology: 15-New Zealand rabbits were selected in this study and divided into 3 groups according to pulp capping period (two days, two and four weeks). calcium hydroxide and Nigella Sativa paste were used for capping upper and lower central incisors (4 incisors). The teeth were restored by glass ionomer cement (GIC) as permanent restorations. After that animal were scarificed and teeth were dissected and prepared for histological evaluation using Hematoxylin Eosin (HE) stains. Results: The results showed that NS caused statistically significantly less severe inflammatory reactions than CH at all-time intervals. Regarding the hard tissue formation, NS showed a statistically significantly thicker formation after a two-week period, while after4 weeks period, all Nigella sativa samples showedhard tissue formation thicker than CH samples but not statistically significant. There were statistically significant differences regarding tissue organization after a period of one and two weeks between NS group and CH group, but after four weeks there were no statistically significant differences. Conclusions: Nigella Sativa paste can be as a direct pulp capping material as it led to a faster hard tissue formation than calcium hydroxide with less inflammation.