mrHARDIflow : A pipeline tailored for the preprocessing and analysis of Multi-Resolution High Angular diffusion MRI and its application to a variability study of the PRIME-DE database (original) (raw)

ABSTRACTThe validation of advanced methods in diffusion MRI requires finer acquisition resolutions, which is hard to acquire with decent Signal-to-Noise Ratio (SNR) in humans. The use of Non-Human Primates (NHP) and anaesthesia is key to unlock valid microstructural maps, but tools must be adapted and configured finely for them to work well. Here, we propose a novel processing pipeline implemented in Nextflow, designed for robustness and scalability, in a modular fashion to allow for maintainability and a high level of customization and parametrization, tailored for the analysis of diffusion data acquired on multiple spatial resolutions. Modules of processes and workflows were implemented upon cutting edge and state-of-the-art MRI processing technologies and diffusion modelling algorithms, namely Diffusion Tensor Imaging (DTI), Constrained Spherical Deconvolution (CSD) and DIstribution of Anisotropic MicrOstructural eNvironments in Diffusion-compartment imaging (DIAMOND), a multi-te...

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact