Polyherbal Compositions Moisture content, Water Activity and Instrumental Colour Values (original) (raw)
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International journal of Pharmacy and Pharmaceutical Sciences, 2014
Objective: The main aim of the study was to standardize the polyherbal formulation on the basis of organoleptic characters, phytochemical analysis, physicochemical parameters and fluorescence analysis. Methods: All the above tests were performed based on WHO norms. Results: Organoleptic characters revealed that formulation was light brown in color, characteristic odor, bitter in taste and moderately fine texture. Physicochemical parameters resulted in water soluble extractive (35.8 ± 0.35), alcohol soluble extractive (38.6 ± 0.24), total ash (9.25 ± 0.12), acid insoluble ash (1.94 ± 0.23), water soluble ash (6.5 ± 0.18), pH (7.49 ± 0.02), crude fat (0.3 ± 0.1), LOD at 105 0 Conclusion: The in-house formulation was prepared and screened for various standardization parameters as per ayurvedic pharmacopoeial standards. C (7.2 ± 0.6) and moisture content (6.2 ± 0.8). Phytochemical analysis shows the presence of alkaloids, tannins, flavonoids, steroids, terpenoids, etc. Fluorescence analysis of formulation was studied using different chemical reagents.
Phytochemical Screening and Standardization of Polyherbal Formulation: Maharishi Amrit Kalash 5
International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Objective: The main aim of the study was to standardize the polyherbal formulation on the basis of organoleptic characters, phytochemical analysis, physicochemical parameters and fluorescence analysis. Methods: All the above tests were performed based on WHO norms. Results: Organoleptic characters revealed that formulation was light brown in color, characteristic odor, bitter in taste and moderately fine texture. Physicochemical parameters resulted in water soluble extractive (35.8 ± 0.35), alcohol soluble extractive (38.6 ± 0.24), total ash (9.25 ± 0.12), acid insoluble ash (1.94 ± 0.23), water soluble ash (6.5 ± 0.18), pH (7.49 ± 0.02), crude fat (0.3 ± 0.1), LOD at 105 0 Conclusion: The in-house formulation was prepared and screened for various standardization parameters as per ayurvedic pharmacopoeial standards. C (7.2 ± 0.6) and moisture content (6.2 ± 0.8). Phytochemical analysis shows the presence of alkaloids, tannins, flavonoids, steroids, terpenoids, etc. Fluorescence analysis of formulation was studied using different chemical reagents.
A Review on Phytochemical Characterization of Kwatha–Ayurvedic Polyherbal Formulation
Journal of Natural Remedies
A paradigm shifts from the conventional approach of a single drug-based system to polyherbal formulations is recently observed in the modern pharmaceutical industry. The rising demand has led to a decrease in the quality and efficacy of herbal medicines. In order to ensure the sustained demand and therapeutic efficacy, it is vitally important to devise proper methods of standardization from the raw drugs to finished polyherbal formulations. However, there is no consensus regarding how these herbal medicines should be standardized. The phytochemical standardization by multiple markerbased fingerprint profiling along with preliminary screening and quantification of marker compounds can assure the reproducibility of the activity of the polyherbal formulations to an extent. The clinically pertinent scientific data to support the asserted synergistic therapeutic effects of Ayurvedic poylyherbal formulations is inadequate. In this review, we discuss the phytochemical standardization and p...
HPLC analysis and standardization of Brahmi vati – An Ayurvedic poly-herbal formulation
Journal of Young Pharmacists, 2013
The aim of the present study was to standardize Brahmi vati (BV) by simultaneous quantitative estimation of Bacoside A 3 and Piperine adopting HPLCeUV method. BV very important Ayurvedic polyherbo formulation used to treat epilepsy and mental disorders containing thirty eight ingredients including Bacopa monnieri L. and Piper longum L. Materials and methods: An HPLCeUV method was developed for the standardization of BV in light of simultaneous quantitative estimation of Bacoside A 3 and Piperine, the major constituents of B. monnieri L. and P. longum L. respectively. The developed method was validated on parameters including linearity, precision, accuracy and robustness. Results: The HPLC analysis showed significant increase in amount of Bacoside A 3 and Piperine in the inhouse sample of BV when compared with all three different marketed samples of the same. Results showed variations in the amount of Bacoside A 3 and Piperine in different samples which indicate nonuniformity in their quality which will lead to difference in their therapeutic effects. Conclusion: The outcome of the present investigation underlines the importance of standardization of Ayurvedic formulations. The developed method may be further used to standardize other samples of BV or other formulations containing Bacoside A 3 and Piperine.
International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Objective: The main objective of this research paper is to evaluate the physico-chemical properties and HPTLC finger print profile of Swasa Kudori Mathirai in the midst of various siddha polyherbal formulations. Methods: Swasa Kudori Mathirai was prepared by the standard operative procedure. It was investigated for physico-chemical properties and HPTLC finger print profile by authenticated methods. Results: The values of loss on Drying at 105°C / moisture content, pH were calculated as 6.52%,5.67 respectively. Total ash, Acid insoluble Ash, Water soluble ash values were found to be 9.81%, 2.24%, 7.38% respectively. Sieve analysis revealed that 24.05%, 31.60%, 34.90% retained in 300 µm,150 µm,75 µm sieves respectively. Uniformity of weight was within the acceptable range. Friability, Hardness, Distintegration Time were found to be 0.2142%, 0.5Kg/cm 2 Conclusion: The results obtained from this study will be a reference data for further research and standardization of siddha formulations in perspective days. , 2 minutes 45 seconds respectively. Bulk density, Tapped density, Angle of repose, Hausner 's ratio, carr index was found to be 0.50 gm/ml,0.
Formulation and Evaluation of Herbal
2018
Hairs are the integral part of human beauty. People are using herbs for cleaning, beautifying and managing hair since the ancient era. As the time has passed synthetic agents have taken a large share but today people are getting aware of their harmful effects on hairs, skin and eyes. These regions attracted to community towards the herbal products, which are less expensive and have negligible side effects. Hair cleansers or shampoos are used not only for cleansing purpose but also for imparting gloss to hair and to maintain their manageability and oiliness for hair. Shampoos are of various types, like powder shampoo, clear liquid shampoo liquid shampoo, lotion shampoo, solid gel shampoo, medicated shampoo, liquid herbal shampoo etc. As far as herbal shampoos are concerned in stability criteria. Depending upon the nature of the ingredients they may be simple or plain shampoo, antiseptic or antidandruff shampoo and nutritional shampoo containing vitamin, aminoacids proteins hydrolysat...
Physicochemical Standardization of Polyherbal Powder Formulation: Safoof-e-Makhana
Pharmacognosy Journal, 2018
Introduction: Safoof-e-Makhana (SM) is a Unani polyherbal powder formulation used to treat Sexual disorders. Formulation consists of following herbs Orchis latifolia, Hygrophila auriculata, Asparagus racemosus and Elettaria cardamomum. The main aim of this study was to standardize Safoof-e-Makhana (SM), on the basis of organoleptic characters and physico-phytochemical analysis. Methods: The drugs were cleaned, dried in shade and powdered by passing through sieve # no. 80 as per the method described in UPI / National Formulary of Unani Medicine. This Safoof formulation was evaluated using physicochemical tests: powder characterization, extractive value, alcohol and water soluble matter, Ash value, LOD at 105 o C, pH and HPTLC fingerprinting. Statistical analysis used: Mean ± SEM. Results: Organoleptic characters of the formulation are light brown colour, characteristic odour, sweet taste and moderately fine texture. Physicochemical parameters displayed water soluble extractive (21.83 ± 0.08), alcohol soluble extractive (7.87 ± 0.09), total ash (4.76 ± 0.08), acid insoluble ash (3.36 ± 0.01), water soluble ash (0.89 ± 0.25), LOD at 105 o C (11.38 ± 0.34), pH of 1% and 10% solution were 6.6 ± 0.1 and 6.0 ± 0.1 respectively. Phytochemical qualitative analysis displayed presence of alkaloids, tannins, flavanoids, steroids, terpenoids, carbohydrates, volatile oil. HPTLC fingerprinting data was also set in. Conclusion: The standardization of this formulation was done and the data obtained would be used as a standard for future reference.
International Journal of Ayurvedic Medicine
Ayurvedic formulation M-Swadista virechana churna is known to be an effective laxative in diseases like Arsha (heamorrhoids), Amasangraha (accumulation of Ama-undigested toxic substance) and Vibandha (constipation). Literature reviews revealed that there are no reports available on the physicochemical standardization & Powder microscopy of "M-Swadishta virechana churna. Hence, analytical studies have been taken up to derive the Pharmacopoeial standards for quality control. The ayurvedic compound formulation, M-Swadishta virechana churna contains Swarnapatri (Cassia angustifolia), Madhuka (Glycerrhiza glabra) and Ikshu Sarkara (cane sugar-Saccharam officinarum). The present communication deals with the physico chemical, preliminary phyto chemical and chromatographic with powder microscopical studies gave valuable parameters for laying down Pharmacopoeial standards of the compound formulation.
EVALUATION OF BIOACTIVITIES OF TWO POLYHERBAL FORMULATIONS FOUND IN SRI LANKAN AYURVEDIC TREATMENTS
IJPSR, 2018
Commercially available two polyherbal formulations (Chandra Kalka and Sharkaradi Kalka) were collected from local market. The objective of this study was to determine the Total Phenolic Content (TPC) , Total Flavonoid Content (TFC) of these two ‘Kalkas’ and to investigate the existence of antioxidant, anti-inflammatory, antibacterial and anti-tyrosinase activities. Total phenolic content and total flavonoid content was determined by Folin Ciocalteu and Aluminium chloride method respectively. Antioxidant activities was evaluated using the DPPH radical scavenging assay and human red blood cell membrane stabilization assay was used to determine the anti-inflammatory activity. Agar well diffusion method and tyrosinase enzyme inhibitory assay was facilitated to investigate the antibacterial and tyrosinase enzyme inhibition properties of the selected polyherbal formulations, accordingly. The results obtained from the study showed that Chandra Kalka has the highest TPC (53.90 ± 948 mg GAE /g extract) and has the highest TFC (119.25 ± 10.11 mg QE/g extract). Sharkaradi Kalka showed higher antioxidant activity for the DPPH radical scavenging, anti-inflammatory activity, and anti-tyrosinase activity for the assays conducted, compared with the Chandra Kalka. Antibacterial assay was conducted against four pathogenic bacteria; Escherichia coli [ATCC 25922], Staphylococcus aureus [ATCC 25923], Bacillus subtilis [MTCC 121] and Staphylococcus epidermidis [ATCC 12228] using agar well diffusion method. No antibacterial activity was observed for either polyherbal formulations at 1 mg/mL dose used. Both Chandra Kalka and Sharkaradi Kalka demonstrate bioactivities to an moderate extend for the assays conducted.