Effects of Komouni Formulation (Herbal Product of Persian Medicine) With a Low-Calorie Diet on Cardiometabolic Risk Factors in Overweight and Obese Women: A Triple-Blinded Randomized Clinical Trial (original) (raw)
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Use of Herbal Medicines in the Treatment of Obesity in Taif, Saudi Arabia
2017
Background: The prevalence of obesity is increasing worldwide. Herbal medicines are one of the most common alternative therapies for weight loss. The aim of this study was to determine the usage rate of herbal medicines in the city of Taif, Saudi Arabia, and which plants were most commonly used to treat obesity. Materials and Methods: This is a cross-sectional study conducted using a pretested questionnaire that was randomly distributed to overweight and obese people in Taif, Saudi Arabia. Results: A total of 422 cases completed the questionnaire with a response rate of 60.3%. The majority of patients (98.1%) used herbal medicines to lose weight, with green tea (88.4%) and ginger (29.5%) being the most commonly used herbs. More than one-third of respondents declared that they suffered from side effects; however, most (72%) of the respondents admitted that they would use herbal medications again. Conclusion: The current study shows a high usage rate of herbal medicines for the treatm...
Efficacy, safety, and mechanisms of herbal medicines used in the treatment of obesity
Medicine
Introduction: This systematic review protocol aims to perform a protocol for assessing the effectiveness, safety, and mechanism of herbal medicines for the treatment of obesity and metabolic syndrome. Some systematic reviews conducted earlier have evaluated the efficacy of herbal medicine to treat obesity and metabolic syndrome. Owing to the huge burden imposed by obesity in the recent years, a need is felt for conducting new systematic reviews on the topic of obesity with a focus on randomized clinical trials, we felt the need. Methods and analysis: All relevant clinical trials that examine the effectiveness of herbal medicines for the treatment of obesity and metabolic syndrome without restrictions on publication status will be applied. Four electronic databases will be searched: PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials. The main outcome is expected to be an improvement in the body weight, body mass index, waist circumference, waist-to-hip ratio, body fat (weight or mass of visceral adipose tissue, fat mass or percent), and appetite. Selection studies, data extraction, and risk of bias will be assessed independently by 2 authors. Ethics and dissemination: In this study, ethical approval is not required because the data that will be used are not subjects and the results will be discussed through peer-reviewed publications.
Electronic Physician
Background: Obesity is a major risk factor for many diseases. In Persian Medicine, much emphasis has been put on the balanced weight that maintains health. Therefore, the treatment of obesity is a top priority for health care in Persian and Classical Medicine. Objective: To compare the efficacy of therapeutic packages in Persian Medicine with Classical Medicine in overweight treatment. Methods: This randomized clinical trial was conducted at Ghaem Hospital in Mashhad, Iran, from August 22, 2016 to December 20, 2016. Sixty-nine overweight women with body mass index (BMI) of 27-29.9 and waist circumference more than 88 cm based on inclusion and exclusion criteria, were included in the study. To control bias in sampling, with considering that the age variable is an interventional factor in the process of effective treatment, in addition to using the random allocation method, the population were studied in three groups of 18-30 years old, 31-50 years old and >50 years old, who were classified by blocking method, and three types of treatment interventions were performed in each age group: Group A (Classical diet and orlistat), Group B (Persian diet and MDB) and Group C (classical diet and MDB). Calorie consumption was equivalent in the three groups. Blinding was done only for patients. The treatment period was three months in all three groups. Subsequently, we analyzed the effectiveness of the therapeutic packages on anthropometric index, body composition and laboratory parameters in the three groups. The data were analyzed using SPSS version 16. We used descriptive statistics, Kolmogorov-Smirnov, ANOVA, paired-samples t-test, non-parametric Wilcoxon test and regression methods for the analyses of primary and secondary outcomes. Results: Although anthropometric index and fat mass decreased highly significantly in all three intervention groups (p<0.001), the B group led to a further decrease in BMI (Mean ± SD: 1.61±1.03), weight (Mean ± SD: Electronic physician Page 6893 4.79±2.26), waist circumference (Mean ± SD: 4.25±0.59) and Fat mass (Mean ± SD: 3.24±2.70), compared with the other two groups. Lipid profile and FBS in groups B and C had significant decrease before and after the intervention, but Group A had no significant effect before or after the intervention. Other laboratory parameters did not change significantly before or after the treatment in the three groups. Conclusion: In this study, Classical Medicine and Persian Medicine had the same levels of effectiveness but Persian Medicine brought a greater reduction in body weight, fat mass%, lipid profile and fasting blood glucose than Classical Medicine during the study period. So Persian Medicine can be effective in weight loss as an alternative therapy, but more studies are needed. Trial registration: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: (IRCT 2016041927477N1).
Phytotherapy Research, 2019
Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards o...
International Journal of Nutrition and Food Sciences, 2014
Herbal products are often marketed for weight reduction in the Kingdom Saudi Arabia, this study aimed to evaluate weight loss claims and safety of three popular herbal products marketed in Riyadh, Albino rats aged 6-7 weeks were fed a diet comprising 15% mixed herbal products and compared with controls, any changes in weight and food intake were recorded. Haemogram, lipid profile and renal and liver function tests were conducted, compared with the control group, the body weight of rats significantly decreased when fed with two herbal products that contain high percentage of caffeine. Weight and food intake non-significantly increased in one group, there were minimal or no significant differences in the haematological and biochemical profiles, herbal products containing senna, sage, cumin and ginger may have beneficial value in managing obesity most likely because of the high content of caffeine. Further studies are necessary in order to confirm this supposition.
THERAPEUTIC POTENTIAL OF ORGANIC HERBAL PRODUCTS IN PREVENTION AND TREATMENT OF OBESITY
Obesity has emerged as a priority in chronic disease prevention and has been linked to increased risk for heart disease, high blood pressure, type 2 diabetes, arthritis-related disability and some cancers. Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle and environmental factors, which favors a chronic positive energy balance, and leads to increased body fat mass. The incidence of obesity is rising at an alarming rate and is becoming a major public health concern with incalculable social costs. The global prevalence of overweight and obesity is increasing due to excessive calorie intake and sedentary lifestyle. Therapeutic strategies include synthetic drugs and surgery, which may entail high costs and serious complications. The pancreatic lipase (PL) is the most important enzyme in digestion of triglycerides. Thus altering metabolism of lipids by inhibiting dietary fat absorption, represents a good strategy in the prevention and treatment of obesity. Since the time immemorial, medicinal plants/herbs have been in use as sources of medicine throughout the world in treatment of chronic ailments. The demand for plant based medicines is ever growing, as natural derived crude or processed products have been found to be associated with less or no adverse effects. As a result, there is great interest in the use of plant-based medicinal agents as an alternative/ complementary therapy intreatment of chronic complex diseases. Recent researches have demonstrated the potential of natural products to counteract obesity. Multiple-natural product combinations may result in a synergistic activity that increases their bioavailability and action on multiple molecular targets, offering advantages over chemical treatments. Efforts have been to develop an organic poly herbal formulation: Weight Balance consisting of three medicinal plants (1) Guruchi (Tinospora cordifolia) (2) Bhumyamalaki (Phyllanthus niruri) (3) Amalaki (Phyllanthus emblica). All three medicinal plants present in above herbal formulation have been found to exhibit therapeutic potential in various disease conditions. These therapeutically active medicinal plants in combination have made this formulation Weight Balance a strong metabolic regulator. Clinical studies have shown the beneficial effect of this formulation on patients with obesity. Weight Balance is an unique formula which provides natural solution to excess weight and obesity. It promotes slow but regular weight loss by accelerating fat metabolism and improving carbohydrate metabolism. It expedites normal fat distribution, best with exercise and diet control, helps in weight reduction through improved metabolism without adverse effects. This organic supplement is also safe for use for those with heart ailments, diabetes mellitus, hypercholesterolemia and arthritis This organic poly herbal formulation can act as Alternative or Complementary Therapy for. treatment of obesity and related syndromes.
Overweight, obesity and the accumulation of excess fat in the body are signs of chronic imbalance between the amount of food taken and the amount of energy consumed .Diet and exercise play an important role in weight loss and success requires changes in behavior. Taking weight loss medicines along with lifestyle changes may be beneficial for some patients.because of high costs and significant side effects, these are not highly effective on the treatment of obesity. Therefore, medicines and other methods with less complications and greater effectiveness are needed for obesity and overweight treatmentthis. In this study after reviewing the Iranian Traditional Medicine books and the modern books and articles, since traditional medicine has a particular view of the problem of obesity, the definition of obesity and its treatment, have been expressed in traditional medicine. In traditional medicine, obesity has been cited as " Samane mofrat " ; in this medicine, treatment for obesity is based on lifestyle modifications; orders are given for How to live ; eating and drinking; physical activity; sleep and awakening; relaxation; bathing; wearing clothes; etc. so by modifying the lifestyle; in case of need for medicine therapy; we can get an appropriate response from the treatment; reduce the side effects of the medicines and, in the long term, treat the patient. Compared to synthetic medicines, very few studies have been conducted on the effectiveness and safety of other weight-reducing treatments, and for this reason no one can be definitely recommended for the treatment of obesity and overweight. Therefore, conducting further research on the effectiveness and safety of these treatments is considered necessary
Vital Potential of Multiple Herbs in Prophylaxis of Obesity
Asian Journal of Pharmaceutical and Clinical Research
Objective: Allopathic medications are associated with several inconveniences such as drug dependency. More than 2000 herbal medicines have been proved to have a therapeutic effect in multiple disorders. The prominent aim of this review paper is to compute the therapeutic effect of herbal drug against obesity along with their different mechanisms. Methods: Data have been selected by evaluating merger of specific review and research papers through filtering through data bases such as PubMed, and Google Scholar of last 10 years 2009–2019. Results: On the basis of our interpretations, we have concluded that the herbal drugs constituting active constituents’ as tannins, alkaloids, resins, saponins, and flavonoids are effective in lowering the blood triglycerides level, lipid accumulation in liver, fat accumulation, adipocyte differentiation, and ultimately decrease body weight with almost negligible toxicity. Conclusion: Obesity is highly related to elevated morbidity rate as well as has...
A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity
World journal of …, 2009
This review focuses on the efficacy and safety of effective herbal medicines in the management of obesity in humans and animals. PubMed, Scopus, Google Scholar, Web of Science, and IranMedex databases were searched up to December 30, 2008. The search terms were “obesity” and (“herbal medicine” or “plant”, “plant medicinal” or “medicine traditional”) without narrowing or limiting search elements. All of the human and animal studies on the effects of herbs with the key outcome of change in anthropometric measures such as body weight and waist-hip circumference, body fat, amount of food intake, and appetite were included. In vitro studies, reviews, and letters to editors were excluded. Of the publications identified in the initial database, 915 results were identified and reviewed, and a total of 77 studies were included (19 human and 58 animal studies). Studies with Cissus quadrangularis (CQ), Sambucus nigra, Asparagus officinalis, Garcinia atroviridis, ephedra and caffeine, Slimax (extract of several plants including Zingiber officinale and Bofutsushosan) showed a significant decrease in body weight. In 41 animal studies, significant weight loss or inhibition of weight gain was found. No significant adverse effects or mortality were observed except in studies with supplements containing ephedra, caffeine and Bofutsushosan. In conclusion, compounds containing ephedra, CQ, ginseng, bitter melon, and zingiber were found to be effective in the management of obesity. Attention to these natural compounds would open a new approach for novel therapeutic and more effective agents.
Lipids in Health and Disease, 2012
Background: The effect of an herbal formulation LI85008F on weight loss in obese human subjects was evaluated in an 8-weeks randomized, double-blind, placebo-controlled study (Clinical Trial Registration no. ISRCTN37381706). Fifty obese subjects (Body mass index 30 to 40 kg/m 2 , 29.3% male; 70.7% female; ages 27-50 years) were randomized into two groups; placebo (n = 25) and LI85008F formulation (n = 25). The participants received either 900 mg/day of LI85008F formulation in three divided doses or three identical placebo capsules and all of them remained on a calorie-controlled diet (2000 cal/day) and 30 min walking for 5 days a week during the entire duration of the study. Results and discussion: At the end of the trial period, LI85008F supplemented group showed significant net reductions in body weight and Body Mass Index (BMI). The participants who received the herbal formulation, showed reduced fasting blood glucose, LDL, LDL/HDL ratio, and triglycerides. At the end of the study, LI85008F supplementation also provided 21.26% (p = 0.012) increase in serum adiponectin level, compared with the placebo group. No major adverse events were reported by the participants in the study duration. In addition, Adipokine profiling study in 3T3-L1 adipocytes demonstrates that LI85008F modulates key regulatory factors of adipogenic differentiation and insulin sensitivity, such as Adiponectin, Pref-1, and resistin. Conclusion: The herbal formulation LI85008F (Adipromin) is prepared from commonly used medicinal plants extracts, which provides useful and safe application for weight loss in obese humans. It also demonstrates potential promise in controlling healthy blood glucose level in obesity linked type 2 diabetes.