Sertoli Cells: Architects of Male Reproductive Function and Clinical Impacts (original) (raw)

The male testes are essential for sperm production and hormone regulation, with Sertoli cells as the unsung heroes orchestrating these processes. This review explores the world of Sertoli cells, discussing their structure, functions, and critical role in spermatogenesis. Named after Enrico Sertoli, these cells are pivotal within seminiferous tubules, forming the blood-testis barrier and providing support to developing germ cells. They also play a vital role in hormone regulation, fetal testis development, and various clinical conditions, including testicular tumors, male infertility, and androgen insensitivity syndrome. Understanding the intricate web of Sertoli cell biology not only enhances our comprehension of male reproductive health but also lays the groundwork for innovative diagnostic and therapeutic approaches in the fields of andrology and endocrinology.