IFN-γ expression is up-regulated by peripheral blood mononuclear cells (PBMC) from non-exposed dogs upon Leishmania chagasi promastigote stimulation in vitro (original) (raw)
2009, Veterinary Immunology and Immunopathology
AI-generated Abstract
This research investigates the early immune response of canine peripheral blood mononuclear cells (PBMC) to Leishmania chagasi, utilizing an in vitro priming system. Results demonstrate that upon stimulation with L. chagasi, IFN-γ mRNA expression is significantly up-regulated in non-exposed dogs' PBMC, while IL-4 and IL-10 expression remained unchanged. The study finds a direct correlation between a lower IFN-γ/IL-4 expression ratio and decreased parasite infection, suggesting that the balance of these cytokines plays a crucial role in controlling the infection.
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