Nano-CuCr2O4: An Efficient Catalyst for a One-Pot Synthesis of Tetrahydrodipyrazolopyridine (original) (raw)
Related papers
Research on Chemical Intermediates, 2016
We have studied the catalytic ability of copper(II) acetate monohydrate as a mild, environmentally benign, natural and economical catalyst for the multi-component efficient synthesis of biologically active spiro-4H-pyran derivatives and 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with excellent yields and short reaction times. The most important advantages of this procedure are its mild, non-toxic and inexpensive catalyst, one-pot synthesis, environmentally benign nature, solvent-free conditions, simple operational procedures, and highly efficient conditions.
Bulletin of the Korean Chemical Society
A simple one-pot synthesis of two derivatives of 1,4-dihydropyridines has been described under reflux conditions using copper iodide nanoparticles (CuI NPs) as a catalyst in high yields. This method demonstrated four-component coupling reactions of aldehydes and ammonium acetate via two pathways. In one route, the reaction was performed using 2 eq ethyl acetoacetate while in the other one 1 eq ethyl acetoacetate and 1 eq malononitrile were used. The CuI NPs was reused and recycled without any loss of activity and product yield. It is noteworthy to state that wide range of the 1,4-dihydropyridines have attracted large interest due to pharmacological and biological activities.
Tetrahedron, 2004
Fused pyridine derivatives R 0450 Synthesis of Novel Hydropyrazolopyridine Derivatives in Solvent-Free Conditions via Benzotriazole Methodology.-Acidic treatment of the pyrazoles (I) and (VI) with unactivated and electron-rich alkenes under solvent-free conditions offers a simple and convenient approach to hydropyrazolopyridines including the novel tricyclic compounds (V) and (VIII). Interestingly, the reaction of (I) and (VI) with styrene gives the same product.-(
Cu(II)-Schiff base/SBA-15 as an efficient catalyst for synthesis of decahydroacridine-1,8-diones
Asian Journal of Green Chemistry, 2017
Herein, we report a fast synthesis of 1,4-dihydropyridines, decahydroacridine-1,8-diones by one-pot multi-component reaction of 1,3cyclohexanedione or dimidone, arylaldehydes, and ammonium acetate under solvent-less condition using Cu(II)-schiff base-SBA-15 as a reusable heterogeneous catalyst in high yields. These kinds of catalysts are built from mesoporous silica SBA-15 which was covalently anchored with Cu(II) schiff base complex. The shorter reaction times, good yields, simple work-up procedure and environmentally friendly conditions are the main advantages of this method compared to the last one. This method is also the first example of synthesizing acridines by Cu(II)-schiff base-SBA-15 as an efficient catalyst in solvent-free media which can be valuable to be used or investigated for similar systems. The product was identified by its 1 H NMR, mass and IR spectra, which were compared to those reported previously.
Polyhedron, 2018
Using a green and simple route with ultrasound illumination, atmospheric pressure and room temperature, for synthesizing tacrine analogues in the presence of [Cu 3 (BTC) 2 ] as an environment-friendly and economically catalyst was considered. [Cu 3 (BTC) 2 ] is one of the heterogeneous catalysts on hand capable of being employed, in the Friedländer reaction, whenever 5-amino-4-cyano-2-phenyl-1,3-oxazole and appropriately substituted carbonyl derivatives under conventional and ultrasonic irradiation. The results of this study indicate that the active sites in the [Cu 3 (BTC) 2 ] for synthesis of cyclohepta[b] oxazolo[4,5-e]pyridine are mainly copper atoms and the role of Brǿnsted acid organic ligand in the MOF is negligible. These procedures were properly arranged in order to provide the utmost yields in a short while. The crystal stability in the process of catalysis was investigated by various techniques such as XRD, BET and ICP that demonstrate excellent stability in reaction conditions.
A novel one-pot, five-component reaction for the synthesis of highly functionalized pyranopyrazoles from acid chlorides, Meldrum's acid, hydrazine hydrate, aromatic aldehydes and malononitrile in the presence of catalytic amount of CuI nanoparticles in aqueous media is reported. This method provides several benefits such as in situ preparation of β-ketoester, mild reaction conditions, and environmentally friendly, waste-free and simple work-up procedure with excellent yields. The catalyst could be recovered and reused for several times with almost consistent catalytic activity. Scheme 1. Synthesis of pyranopyrazole derivatives catalyzed by CuI nanoparticles under reflux conditions.