Time-of-Flight Secondary Ion Mass Spectrometry Studies of in Vitro Hydrolytic Degradation of Biodegradable Polymers (original) (raw)

Macromolecules, 1999

Abstract

The in vitro hydrolytic degradation at the surface of six biodegradable polymers, namely polyglycolic acid (PGA), poly(lactic acid) (PLA), random copolymer poly(lactic-co-glycolic) acid (PLGA), poly(sebacic acid) (PSA), and two random copolymer poly(fumaric-co-sebacic) acid (PFS) of different compositions, has been studied using time-of-flight secondary ion mass spectrometry (ToF SIMS). A distribution of hydrolysis products, namely oligomer molecules, were observed as a series of intact molecular ions in the ToF SIMS spectra for all polymers studied. In most cases, the molecular ion peak in each repeating pattern is the most intense peak. Analysis of the intensities of the molecular ions in the distribution (e.g., approaching Mn) allows chemical kinetic information to be obtained from the ToF SIMS spectra of hydrolyzed samples. In the case of polyglycolic acid, a maximum in the distribution of the molecular ion peaks is observed which changes with respect to the hydrolysis time. For PGA, the average molec...

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