Metastatic oral squamous cell carcinoma in a captive common hippopotamus (Hippopotamus amphibius) (original) (raw)
Related papers
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2017
An adult female captive pygmy hippopotamus (Choeropsis liberiensis) was diagnosed with an oral anaplastic sarcoma. The tumor was surgically debulked and intralesional chemotherapy with mitomycin C (0.4 mg/cm(3) of tumor) and cisplatin (1 mg/cm(3) of tumor) was administered. Chemotherapeutic treatment proved difficult due to the risks of repeated anesthetics and unknown drug efficacies. Marked proliferation of the mass was observed during estrus, and chemotherapy was repeated as an experimental treatment to slow tumor progression in order for the animal to remain in the species breeding program. Tumor proliferation was detected during the first trimester of pregnancy; however, in the lactation period, the mass became quiescent. No adverse reactions to chemotherapeutic drugs were observed and the animal continues to be monitored for tumor progression. This is the first report of an anaplastic sarcoma and of chemotherapy use in a pygmy hippopotamus and it highlights logistical consider...
A case report of squamous cell carcinoma in buffalo
2018
A local breed of buffalo, Murrah cross 4.5 years old with a tumor on its forelimb of left leg on the lateral side of metacarpal, suspected as squamous cell carcinoma is discussed in this study. As primary sign animal showed awkward gait and difficulty in movement. Initially the mass was seen as wart like structure and later on progressed to the formation of bulky mass of cancerous cells in the span of three months. The attempt to treat by chemotherapy was unsuccessful during the course. The tumor was surgically removed after fine needle aspiration cytology. Histopathological examination performed on the removed mass showed underlying acanthosis and hyperkeratosis. Thus, the case was confirmed as squamous cell carcinoma. Post-operative care was provided to the animal after the surgery. The main aim of this study was to differentiate the nature and type of tumor and to provide a way to further proceed the treatment in similar cases.
Squamous cell carcinoma in a wild European bullhead Cottus gobio
Diseases of Aquatic Organisms, 2016
A pharyngeal tumor was found in a wild European bullhead. The tumor mass appeared underneath the operculum and was bilobed. The major neoplastic component showed diffuse epithelial squamous differentiation. Crossmonn's trichrome allowed identification of connective tissues whereas no neoplastic cells were stained. Periodic acid-Schiff was negative within the mass, and Giemsa did not show any further diagnostic significance. Immunohistochemistry showed diffuse positive cytoplasmic staining of the neoplastic population with an anti-human pancytokeratin antibody. Vimentin was negative and exclusively stained the stroma. On the basis of the morphological and immunohistochemical results, a squamous cell carcinoma was diagnosed.
2020
Squamous cell carcinoma (SCC) is frequently seen as an invasive cutaneous tumour that can be fatal in animals. In this case series, the clinical management of histopathologically diagnosis of SCC in three different individuals of African pygmy hedgehogs is described. In two of the cases presented, the tumours were presented as an oral mass on the gingiva, which were ulcerative and septic. Lumpectomy was performed in both cases and histopathology revealed encapsulated mass composed of neoplastic cells showing squamous differentiation arranged in islands with presence of keratin pearls, intercellular bridges and frequent mitotic figures which are typical features of squamous cell carcinoma. Following lumpectomy, the two hedgehogs were discharged but were later found to developed ocular lesion and anorexia before they were found dead. In the third case, SCC was diagnosed on the phalanges of the 3rd and 4th digits and surgical resection was successfully performed in this case and post-s...
Spontaneous neoplasms in zoo mammals, birds, and reptiles in Taiwan – a 10-year survey
Animal Biology, 2012
The characteristics of 163 spontaneous neoplasms diagnosed in 150 necropsied zoo mammals, birds, and reptiles at Taipei Zoo during 1994-2003 were analyzed. Histopathology and immunohistochemistry were employed to classify the tumor types. A total of 2657 necropsied zoo animals, including 1335 mammals, 873 birds and 449 reptiles led to the diagnosis of tumor in 8.1% (108/1335), 4.2% (37/873) and 1.1% (5/449) of cases, respectively. The most predominant type of tumors in mammals was mammary gland tumors (12.0%, 13/108), followed by uterine smooth muscle tumors (10.2%, 11/108), lymphosarcoma (9.3%, 10/108), hepatocellular carcinoma (8.3%, 9/108), and cutaneous squamous cell carcinoma (6.5%, 7/108). The avian neoplasm with the highest incidence was lymphosarcoma (35.1%, 13/37). Five individual neoplasms were found in different reptile species. The overall incidence of malignant tumors (63.8%, 104/163) was greater than that of benign tumors (36.2%, 59/163). Immunohistochemistry character...
Cancer Prevalence and Etiology in Wild and Captive Animals
2017
Neoplasia has been recorded in the vast majority of metazoans. The frequent occurrence of cancer in multicellular organisms suggests that neoplasia, similar to pathogens/parasites, may have a significant negative impact on host fitness in the wild. This is supported by the fact that wildlife cancers have recently been shown to result in significantly increased levels of mortality and concomitant reduction in fitness. By thorough searches of the available literature we provide a comprehensive and an updated list of cancer prevalence and etiology in the wild. We were, however, unable to find data on nontransmissible cancer prevalence in invertebrates and consequently this chapter focuses on cancer in wild vertebrates. Although single cases of cancer are frequently encountered in the wildlife, we were only able to retrieve robust data on cancer prevalence for 31 vertebrate species (12 fish, 3 amphibians, 2 reptiles, 2 birds, and 12 mammals). Cancer prevalence among these vertebrates ra...
Veterinary Sciences, 2018
Oral squamous cell carcinoma (SCC) is a common finding in domestic and wild felids. Only two cases of oral SCC have been reported in Lynx species (Lynx rufus and Lynx canadensis), at mandibular and gingival sites. In this study, we describe the first report of tongue SCC in a 15 years old female European lynx (Lynx lynx), along with viral investigations. Necropsy and histological analysis were performed and the presence of papillomavirus (PV) infection was investigated by ultrastructural and molecular methods. The lardaceous mass at tongue level was histologically diagnosed as moderately differentiated SCC. Typical microscopical features of SCC were also found in the retropharyngeal lymph node and at the pulmonary level. Neither viral DNA by PCR, nor viral particles by transmission electron microscopy were found. Despite that PV infection is associated with Felidae, this work reports the first description of tongue SCC in Lynx species, but no evidence of PV infection, suggesting that PV may not be involved in development of SCC in bobcat species.
Journal of Veterinary Clinics
A 14-year-old intact male captive leopard (Panthera pardus) first presented with a focal alopecic lesion on the dorsal aspect of the distal one-third of its tail. Although itraconazole was administered, the lesion progressed deeper and became ulcerated due to self-trauma. Due to the wild nature of the leopard, daily dressing of the wound and replacing the bandages without anesthesia became too dangerous, and amputation became necessary. A postoperative tissue sample was submitted for histopathological examination, and tramadol, amoxicillin/clavulanate, and gabapentin were administered. In the days following the amputation, the leopard's appetite significantly decreased, and the patient passed away 18 days later. Histopathological examination of the specimen revealed well-differentiated squamous cell carcinoma (SCC). In hindsight, had more cells been collected by a fine-needle aspirate (FNA) biopsy or had additional FNA biopsies been performed, SCC might have been diagnosed based on its cytological features rather than delayed histopathological findings. The current study highlights the critical reasons why clinicians may often misdiagnose SCC and the importance of being more aware of potential tumors in ulcerative lesions, which are often incorrectly treated as infectious skin diseases. This is also the first report of cutaneous SCC in a leopard.
Clinicopathologic evaluation of oral squamous cell carcinoma in a young dog
Ankara Universitesi Veteriner Fakultesi Dergisi, 2020
Canine oral papillomas is a benign tumor of young dogs and caused by papillomavirus. The possible role of papillomavirus infection in the development of oral squamous cell carcinoma has recently been studied, but it has not been elucidated in veterinary medicine yet. One-year-old, mixed, spayed, a female dog was presented with severely disseminated oral lesions, lethargy, and weight loss. Physical examination of the patient revealed severely disseminated oral papillomatous lesions in the entire oral cavity and the complete blood test showed mild non-regenerative anemia and pancytopenia. In addition, the patient was found seropositive by the SNAP 4Dx Plus test for Ehrlichia canis. Histopathologic examination of oral lesions was performed using Hematoxylin and Eosin (HE) staining and immunohistochemistry for p16 antibody which increases in infections caused by papillomavirus. Histopathology revealed the histologic features of oral papilloma in association with squamous cell carcinoma....