Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6 (original) (raw)
Related papers
PubMed, 2006
This study aimed to 1) compare levels of high sensitivity c-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) between overweight Thais and apparently healthy controls, and 2) investigate the association between serum hs-CRP, IL-6, and TNF-alpha levels and other biochemical parameters. A total of 180 health-conscious adults aged 25-60 years, who resided in Bangkok, participated in this study. No significant difference was found in age and sex between the overweight subjects and controls. Serum levels of hs-CRP, IL-6, TNF-alpha, glucose, lipid profile, body mass index (BMI), waist circumference (WC), hip circumference (HC) and waist hip ratio (WHR) were determined in these volunteers. The mean levels of white blood cells (WBC), uric acid, total cholesterol (TC), triglyceride (TG), and hs-CRP were significantly higher in the overweight subjects than those in the controls, whereas high density lipoprotein-cholesterol (HDL-C) values were significantly higher in the controls than the overweight subjects (p < 0.05). Hs-CRP levels were significantly positively correlated with levels of TG, BMI, WC, HC and WHR. HDL-C levels were significantly negative correlated with hs-CRP levels. In conclusion, the prevalence of elevated serum hs-CRP levels was higher in overweight subjects than controls. However, more data in larger and other population groups are needed to confirm this study.
ADIPOCYTOKINES AND C-REACTIVE PROTEIN IN OBESITY
jmed.ro
Cardiovascular diseases represent the main cause of morbidity and mortality in overweight and obese patients. The atherosclerosis process represents the morphopathological substrate of these illnesses. The purpose of this study was to analyze the link between some specific adipocytokines (such as leptine) and some non-specific ones (such are IL-6, TNF-a), the insulin resistance, the reactive C protein, and the weight condition. The study group was homogenous as age and sex and consists of 30 persons (10 obese, 10 with overweight and 10 normoponderal). We found a strong direct correlation between the BMI and the leptine level (r=0.83), as well as between the insulin resistance (HOMAIR evaluated) and the abdominal circumference (r=0.90). PCRus, had a strong direct correlation with CT (r=0,82), LDLc (r=0,81) and BMI (r=0,79). At obese and overweight persons pro-inflammatory cytokines were increased, versus normoponderal people. That explains their increased cardiovascular risk. The levels of specific and non-specific adipocytokines, as well as the level of reactive C protein, were directly linked with the BMI and the abdominal circumference. As a clinical aspect, the abdominal circumference is the best indicator for insulin resistance.
Relationship between C‐reactive protein and visceral adipose tissue in healthy Japanese subjects
Diabetes, Obesity and Metabolism, 2004
Aim: Recent studies have suggested that the elevated C‐reactive protein (CRP) levels are associated with body fat, especially visceral adipose tissue, but most of them were investigated in Westerners who had higher body mass index (BMI) than Asians. To investigate the association between CRP concentrations, parameters of visceral obesity, the insulin resistance syndrome and carotid atherosclerosis in healthy Japanese who had a lower BMI than Westerners.Methods: We explored the relationships between fatness and visceral obesity parameters [by anthropometry, bioelectrical impedance analysis and abdominal computed tomography (CT)] and CRP (high sensitivity) and examined their associations with components of insulin resistance syndrome, interleukin‐6 (IL‐6), tissue necrosis factor‐α (TNF‐α) and intima‐media thickness (IMT) of common carotid arteries (CCAs) by ultrasonograms in 116 healthy Japanese subjects.Results: In crude regression analyses, CRP was significantly associated with m...
Obesity and High Sensitivity C-Reactive Protein Level in Indian Population
2019
The study was aimed to assess the relation between high sensitivity C-reactive protein (hs-CRP) and obesity in Indian population. Obesity is increasing to epidemic proportions in India to such an extent that the prevalence of obesity has also been found to be rising in children and adolescents leading to various coronary events and inflammatory conditions like cardiac disorders, atherosclerosis etc. in young adults. Obesity is associated with the release of many inflammatory cytokines from adipose tissue among which IL-6, one of the proinflammatory cytokines produced from adipose tissue, plays a major role in stimulating the release of CRP-a novel inflammatory marker released from the liver. In this study, we tried to study the role of hs-CRP and the trend of its increase in Indian population with various levels of obesity. The subjects in the study were participants from voluntary health check-up in MedicineOPD at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India....
Endokrynologia Polska, 2014
Metabolically obese normal weight (MONW) subjects, despite their normal BMI, present metabolic disturbances characteristic of abdominal obesity. One of the reasons might be subclinical inflammation caused by the fat tissue excess. The aim of this study was to assess the association between the accumulation of fat (especially abdominal) and the concentration of selected proinflammatory cytokines - interleukins (IL-6, IL-18) and C-reactive protein (CRP). The study population consisted of 342 subjects (218 women, 124 men; age 20-40 years, BMI < 27 kg/m2) recruited from a community centre in Wroclaw. The group was divided based on the homeostasis assessment insulin resistance index (HOMA) value: 90 MONW subjects with HOMA > 1.69 and 252 subjects as control group. Anthropometric parameters, serum IL-6, IL-18, CRP, glucose, insulin concentrations and insulin sensitivity/resistance indexes were evaluated. CRP levels were significantly higher (3.26 vs. 1.97, p = 0.03) in MONW women th...
Vojnosanitetski pregled, 2018
Background/Aim. Overweight/obesity has become important health problem in developed countries. It may be related to a presence of low-grade inflammation in white adipose tissue. The aim of this study was to investigate the levels of inflammatory marker C-reactive protein (CRP) and its relation to anthropometric parameters in overweight and obese females. Methods. This study included 200 apparently healthy, overweight and obese women (18?45 years). Their standard and alternative anthropometric parameters [body mass index (BMI), percentage of fat (%F), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI)] were determined and correlated to serum CRP concentration. Results. Average CRP level was 5.56 ? 2.43 mg/L, and it significantly positively correlated to all investigated anthropometric parameters. There was significant difference between overweight and obese group in all investigated anthropometric parameters, as well as in CRP...
Obesity Facts, 2012
Objective: To assess the associations between obesity markers (BMI, waist circumference and %body fat) and inflammatory markers (interleukin-1  (IL-1 ); interleukin-6 (IL-6); tumor necrosis factor-␣ (TNF-␣) and high-sensitivity C-reactive protein (hs-CRP)). Methods: Population sample of 2,884 men and 3,201 women aged 35-75 years. Associations were assessed using ridge regression adjusting for age, leisure-time physical activity, and smoking. Results: No differences were found in IL-1  levels between participants with increased obesity markers and healthy counterparts; multivariate regression showed %body fat to be negatively associated with IL-1 . Participants with high %body fat or abdominal obesity had higher IL-6 levels, but no independent association between IL-6 levels and obesity markers was found on multivariate regression. Participants with abdominal obesity had higher TNF-␣ levels, and positive associations were found between TNF-␣ levels and waist circumference in men and between TNF-␣ levels and BMI in women. Obese participants had higher hs-CRP levels, and these differences persisted after multivariate adjustment; similarly, positive associations were found between hs-CRP levels and all obesity markers studied. Conclusion: Obesity markers are differentially associated with cytokine levels. %Body fat is negatively associated with IL-1  ; BMI (in women) and waist circumference (in men) are associated with TNF-␣ ; all obesity markers are positively associated with hs-CRP.
Biomedical Research-tokyo, 2011
Obesity is associated with a low-grade inflammation of white adipose tissue (WAT) resulting from chronic activation of proinflammatory molecules: C-reactive Protein(CRP), TNFalpha and interleukin-6 (IL-6).These cytokines subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes. This is a cross-sectional, open label, comparative, observational study, in a North Indian population cohort. Thirty cases of obesity were evaluated, against twenty normal weight regarding metabolic and inflammatory markers in relation to cardiovascular risk factors. All patients underwent detailed clinical and biochemical, CRP and TNF-α estimation at baseline and at the end of the study period. The differences between the percentage changes in each parameter in the two groups was compared by applying the unpaired t-test using the SPSS 10.0 software. Comparison showed significant difference in CRP and TNF-α between normal weight individuals (BMI<30) and obese individuals (BMI>30) at a p value <0.001. Similarly comparison of total cholesterol, LDL-cholesterol, HDL-cholesterol and Triglyceride levels, showed significant difference between normal weight individuals (BMI<30) and obese individuals (BMI>30) at a p value <0.05. Inflammatory markers like TNF-α and CRP levels were elevated in obese subjects, reinforcing the view that obesity is in part an inflammatory disorder. Further there was evidence of worsening dyslipidemia with BMI and cardiovascular risks The study also suggested that inflammatory marker TNF-α is correlated with cardiovascular risk factors in obesity, rather than just being a manifestation of the inflammatory state.
Obesity Surgery, 2012
Background Obesity is associated with a low-grade inflammatory state. A causal association between inflammation and atherosclerosis has been suggested. The aim of this study was to evaluate changes in the proinflammatory profile of morbidly obese patients after weight loss following bariatric surgery. Methods In this study, we measured levels of adiponectin, high-sensitivity C-reactive protein (hs-CRP), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) and their relation to insulin resistance and lipid parameters in 60 morbidly obese women at baseline and 3, 6 and 12 months after gastric bypass. Results Twelve months after surgery, there was a significant increase in plasma levels of adiponectin (p<0.001) and highdensity lipoprotein cholesterol (p<0.01) and a significant decrease in levels of IL-6 (p<0.001), hs-CRP (p<0.001), cholesterol (p<0.001), triglycerides (p<0.001), low-density lipoprotein cholesterol (p<0.001), glucose (p<0.001), insulin (p<0.001) and homeostasis model assessment (HOMA; p<0.001). At 12 months, correlations were seen between IL-6 levels and the following: body mass index (BMI) (r00.53, p<0.001), insulin (r00.51, p<0.001) and HOMA (r00.55, p<0.001). Also, hs-CRP levels correlated with BMI (r00.40, p00. 004), triglycerides (r00.34, p00.017), insulin (r00.50, p00.001) and HOMA (r00.46, p00.002). Conclusions In patients with morbid obesity, significant weight loss is followed by a significant improvement in the inflammatory state, insulin sensitivity and lipid profile. A relationship exists between improved inflammatory profile and insulin sensitivity.
2011
Obesity is associated with a low-grade inflammation of white adipose tissue (WAT) resulting from chronic activation of proinflammatory molecules: C-reactive Protein(CRP), TNFalpha and interleukin-6 (IL-6).These cytokines subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes. This is a cross-sectional, open label, comparative, observational study, in a North Indian population cohort. Thirty cases of obesity were evaluated, against twenty normal weight regarding metabolic and inflammatory markers in relation to cardiovascular risk factors. All patients underwent detailed clinical and biochemical, CRP and TNF-α estimation at baseline and at the end of the study period. The differences between the percentage changes in each parameter in the two groups was compared by applying the unpaired t-test using the SPSS 10.0 software. Comparison showed significant difference in CRP and TNF-α between normal weight individuals (BMI<30) and obese individuals (BMI>30) at a p value <0.001. Similarly comparison of total cholesterol, LDL-cholesterol, HDL-cholesterol and Triglyceride levels, showed significant difference between normal weight individuals (BMI<30) and obese individuals (BMI>30) at a p value <0.05. Inflammatory markers like TNF-α and CRP levels were elevated in obese subjects, reinforcing the view that obesity is in part an inflammatory disorder. Further there was evidence of worsening dyslipidemia with BMI and cardiovascular risks The study also suggested that inflammatory marker TNF-α is correlated with cardiovascular risk factors in obesity, rather than just being a manifestation of the inflammatory state.