Adenosine Protects Against Indomethacin-Induced Gastric Damage in Rats (original) (raw)
1998, Digestive Diseases and Sciences
This study examines the putativegastroprotective effect of adenosine onindomethacininduced gastric lesions and the possiblemechanisms involved. After 24 hr of starvation, the ratswere treated either with indomethacin (Indo; 25 mg/kg,subcutaneously) alone or adenosine + Indo (Ado; 7.5mg/kg, subcutaneously, three times a day), or thevehicle (5% NaHCO3, subcutaneously). Thelength of hemorrhagic lesions in the stomachs was expressed as the lesionindex. The tissue-associated
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