Some Haematological Parameters in Primary Hypertensive Subjects Attending a Tertiary Hospital in Nigeria (original) (raw)
Related papers
BMC Hematology
Background: Hypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological parameters may enhance an end-organ damage. Therefore, the aim of this study was to assess some hematological parameters of hypertensive individuals in comparison with normotensive individuals at University of Gondar hospital, northwest Ethiopia. Methods: A cross sectional comparative study was conducted from October to November 2015 on a total of 126 hypertensive and 126 normotensive individuals at University of Gondar Hospital. All participants after taking informed consent were interviewed for detailed history and 3 ml of blood was collected for hematological test analysis. Independent t-test and the Mann Whitney u-test were used to find out significant difference and Pearson's and Spearman's correlation were used for correlation test. P values less than 0.05 was considered the level of significance. Result: From a total of 252 study subjects, about 67.5% were females. The mean age of study subjects was 50.3 ± 11 years for hypertensive individuals and 49.8 ± 11.6 years for normotensive individuals with range of 18-65 years. In the present study, the median (IQR) value of WBC, RBC, Hgb, HCT, MCV and the mean value of MCHC, RDW, MPV and PDW were significantly higher in hypertensive group compared to apparently healthy normotensive groups. Additionally, WBC, RBC, Hgb, HCT and PLT showed statistically significant positive correlations with blood pressure indices. Platelet count and MCH did not show statistically significant difference between the two groups. Conclusion: Hypertension has impact on hematological parameters. In this study, the mean and median values of haematological parameters in hypertensive individuals were significantly different compared to apparently healthy normotensive individuals. Hence, hematological parameters can be used to monitor the prognosis of the disease and manage hypertensive related complications, and it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated hematological disorders.
International Journal of TROPICAL DISEASE & Health, 2020
Aim: The Complete Blood Count (CBC) among hypertensive subjects in Isiala Mbano, Imo State, Nigeria West Africa were studied. Methodology: The American College of Cardiology/American Heart Association (2017) current definition of hypertension was used to ascertain, diagnoses and assigned eighty (80)hypertensive subjects after three different consecutive blood pressure check into tests groups. Other blood pressure measures such as pulse pressure and mean arterial pressure were calculated appropriately. Venous blood samples were collected with 5mls syringe and immediately emptied into EDTA container for complete blood count analysis. Results: The results showed increase in RBC count, HB, PCV and decrease in MCV among hypertensive subjects compared with normotensive subjects. It was statistically insignificant in all age groups. No changes were seen in MCHC and MCH. The results also, showed increase in PLTS count. The increase in PLTS count was statistically significant at P<0.05 an...
PLoS ONE, 2021
Background Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia. Methods A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant’s socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. S...
Blood Pressure and Haematological Indices in Twelve Communities in Ashanti, Ghana
International Journal of Hypertension, 2018
Hypertension is the most important risk factor for cardiovascular mortality and morbidity in Sub-Saharan Africa. In western populations, high haemoglobin levels are associated with raised BP unlike in Sub-Saharan Africa where there is a paucity of data. Our study examines the association between haematological indices with BP variables. Weight, height, BP, and whole blood indices of viscosity (Hb, haematocrit, RBC count, and MCV) were measured in 921 adults (340 men, 581 women; aged 40–75) in 12 communities in Ghana. Mean values for Hb (12.3 g/dl ± 1.7 SD), haematocrit (36.7%±5.2), RBC (4.10 million/μL ± 0.64), and MCV were lower than reference values used in Sub-Saharan Africa. Mean BMI was 21.1±4.1 indicating a lean population. Systolic BP increased by 1.0 mmHg (95% CI 0.5–1.5), p<0.001, for women and 0.5 (0.1–1.0), p=0.027, for men per unit increase in haematocrit. Similar relationships were found for Hb and RBC but not for MCV or platelets. The relationships were weaker when ...
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
Sex variations in some haemorheological parameters: Haematocrit (Hct), Erythrocyte Sedimentation Rate (ESR), Hemoglobin concentration (Hbc), Fibrinogen concentration (FC), Relative Plasma Viscosity (RPV) and Whole Blood Relative Viscosity (WBRV) were determined in 30 male and 20 female hypertensive subjects without complications, aged between 30 and 70 years. 30 male and 20 female normotensive subjects aged between 29 and 71 years, matched for age, weight and height with the hypertensive group served as control. In both groups all the parameters were determined using methods previously described by various workers. Results obtained in normotensives showed a significantly lower systolic blood pressure, mean arterial pressure, haematocrit and whole blood relative viscosity and a significantly higher erythrocyte sedimentation rate in female subjects compared to male subjects, no significant correlation was found between any of the haemorheological parameters and the blood pressure indi...
Clinical profile of hypertension at a University Teaching Hospital in Nigeria
2013
Background: Hypertension in Nigeria is a widespread problem of immense social and economic importance because of its high prevalence and the severity of its complications. Aim: To define the morbidity and mortality pattern of hypertension at the University of Port Harcourt Teaching Hospital (UPTH). Method: Records of all patients admitted to the medical wards of the UPTH over a 5-year period with essential hypertension or any of its complications were retrieved from the ward and medical records and reviewed. Result: A total of 780 hypertensive patients were reviewed, constituting 28.2 % of all medical admissions. Only 424 (15.2%) had complete records and were analyzed. Record keeping was poor. There were 173 (41%) males and 251 (59%) females with a male to female ratio of 1:1.5. The ages ranged from 18 years to 100 years with a mean of 56.5 ± 16.2. Stroke was responsible for 169 (39.9%) hypertensive complications. Heart failure occurred in 97 (22%) cases while renal failure and ence...
Comparison of hematological parameters in primary hypertensives and normotensives of Sangareddy
International Journal of Biomedical Research, 2015
Background: Hypertension is the major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases. Aim: The aim of present study was to evaluate the hematological changes in primary hypertension in Sangareddy, Andhra Pradesh. Materials and Methods: In the present study, a total of 100 patients diagnosed for primary hypertension and 100 normotensive subjects were included. All the participants after taking informed consent were subjected to detailed history and hematological analysis. Students-'t' test was used to find out the significance of differences. P values less than 0.05 was considered the level of significance. Result: It was observed that the mean values of Hemoglobin, Erythrocyte count, Hematocrit, MCH and MCHC were increased in primary hypertension while, the mean levels of MCV were found to be lower in the hypertensive group when compared to normotensive subjects. Conclusion: Hypertension has impact on hematocrit, hemoglobin, RBC count, WBC count and Platelet count which can be used for early detection of hypertensive prone individuals.
Establishment of reference values for selected haematological parameters in young adult Nigerians
PLOS ONE, 2019
Background Haematological reference values are necessary for accurate diagnosis of diseases, clinical decision-making, treatment monitoring and clinical research. Due to unavailability of pan-Nigerian reference values, local results interpretation is based on the use of Western values. Objective This study aims to establish national reference values for some haematological parameters in apparently healthy young adult Nigerians. Methods Seven Thousand, Seven Hundred and Ninety-Seven (7,797) volunteers aged 18 to 26 years participated in the study. Participants' interviewer-administered questionnaires and blood samples were collected, analyzed and those with confounding factors (HIV infection, Hepatitis B sero-positivity, Malaria and Pregnancy) were excluded from statistical analysis. The 95-percentile reference range was determined for each haematological parameter using SPSS Version 16 ®. The result obtained was reviewed with reference to already established reference values in two West African and Western countries. Results Blood specimens from 6153 (78.9%) participants [comprising 5915 (96.1%) males and 238 (3.9%) females] were analyzed after exclusion of 1,644 (21.1%) participants with confounding variables. Reference ranges among males and females varied and these were consistent with findings from two other West African countries. The median platelets count in this study was 218 x 10 9 /l while commonly used Western value is 280 x 10 9 /l. Other haematological parameters in the study were similar to Western values.
Hypertension: Prevalence in a Nigerian Adult Population
2020
Background: Hypertension, one of the non communicable diseases of public interest is affecting adults globally with increasing prevalence ravaging adults in developing countries especially in Africa. Hypertension, according to reports has high prevalence, low control rate and cardiovascular complications. Prevalence of hypertension is high in Nigeria and the overall awareness of raised blood pressure among hypertension cases is low in the country. The aim of this study was to evaluate the prevalence of hypertension in undiagnosed adults in Warri metropolis in a developing country of Nigeria. Methods: Total of 420 adults comprising 210 males and 210 females randomly selected across Warri metropolis aged 21-85years were recruited to participate in the study. Blood Pressure was measured using automated digital Sphygmomanometer according to standard method. The results were categorized according to World Health Organization Blood Pressure chart. Results: Total of 42.2% of the population was observed with systolic high blood pressure while 47.1% and 29.1%of the male and female populations were observed with systolic high blood respectively. About 15.0% of the total population was observed with diastolic high blood pressure. Conclusion: Need for both government and nongovernmental organizations to increase public health education to increase awareness campaigns for regular community based monitoring of high blood pressure because of the associated risk factors is necessary.
Reference values of haematological parameters of healthy adults in the north central zone of Nigeria
2015
Background: Haematological parameters differ from one population to another due to several factors. To determine the clinical implication of the blood parameters of an individual in the state of health or disease, we need to have the knowledge of the normal reference range for that locality. Objectives: To determine the reference values of haematological parameters of apparently healthy adults in Ilorin. Design: A descriptive cross sectional study. Setting: Ilorin, North Central zone of Nigeria Subjects: Nine hundred and ten (443 males and 467 females) randomly selected normal, HIV negative individuals aged 18-65 years Results: The red blood cell count, Haemoglobin concentration, PCV and MCHC were significantly higher among males than females while the platelet count, total WBC count and absolute neutrophil count were significantly higher in females than in males. There was however no significant gender difference in the values of MCV, MCH and absolute lymphocyte count. The normal r...