Controlled delivery of ibuprofen from poly(vinyl alcohol)−poly(ethylene glycol) interpenetrating polymeric network hydrogels (original) (raw)

Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous Delivery System

Pharmaceutics

Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability towards poorly soluble drugs and promote/sustain drug release. However, formation of CD-based nanogels requires the use of specially modified CDs, or of crosslinking agents. The aim of this work was to develop a CD-based nanogel to improve the cutaneous delivery of ibuprofen by using the soluble β-cyclodextrin/epichlorohydrin polymer (EPIβCD) without adding any potentially toxic crosslinker. The use of EPIβCD enabled increasing ibuprofen loading due to its complexing/solubilizing power towards the poorly soluble drug and prolonging drug release over time due to the nanogel formation. DLS analysis proved that EPIβCD allowed the formation of nanostructures ranging from 60 up to 400 nm, depending on the gelling agent type and the gel preparation metho...

Cyclodextrin modified hydrogels of PVP/PEG for sustained drug release

Drug Delivery, 2009

Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist wound healing into the gel matrix. Controlling the release of active compounds from the hydrogels may be possible by carefully modifying the polymer matrix. For this purpose, cyclodextrins (CD) were grafted to the polymer matrix in 4-5 w/w% in an attempt to retard the release of water-soluble drugs. Ibuprofenate (IBU) was chosen as model drug and loaded in IBU/CD ratios of 0.6, 1.2, and 2.5. Vinyl derivatives of α-, β-and γ-CD were produced, added to the prepolymer blend and cured by UV-light. During this curing process the CD derivatives were covalently incorporated into the hydrogel matrix. The modified hydrogels were loaded with ibuprofenate by swelling. The release of the model drug from CD modified hydrogels show that especially covalently bonded β-cyclodextrin can change both the release rate and the release profile of ibuprofen.

Novel Composite pH Controlled Drug Release Hydrogel Containing Dexibuprofen

2018

Objective: The objective of this study was to develop a gelatin-cyclodextrin hydrogel using glutaraldehyde as crosslinker containing Dexibuprofen, characterized by the mucoadhesive and controlled release of drug in the stomach and its in vitro characterization. All non-steroidal anti-inflammatory drugs (NSAID's) cause peptic ulcer in chronic disease condition like rheumatoid arthritis. In conventional dosage form of NSAID's the drug is released at once with reduced duration of action. On other hands in hydrogels dosage form the drug is released slowly with prolongs the duration of action & minimal side effects. This also decreases the dosing frequency. Methods: Nine formulations were developed by varying the gelatin-cyclodextrin (Gel/CD) and glutaraldehyde. Swelling studies of hydrogels were performed at three different pH conditions (1.2, 6.5 and 7.4). The hydrogel samples were also analyzed by Fourier transformed infrared spectroscopy (FTIR), Differential scanning calorime...

MODIFIED RELEASE HYDROGELS OF IBUPROFEN FOR ORAL DRUG DELIVERY: AN OVERVIEW

The Present study for hydrogels are specifically on the pH sensitive hydrogels for oral drug delivery system. Hydrogels are able to improve oral delivery of several therapeutic agents established by various in-vitro methodologies. Hydrogels are basically cross-linked polymers with hydrophilic nature & consist of acidic, basic, or neutral monomers which are able to swallow large amounts of water. Due to hydrophilic nature of polymer chains, hydrogels will engross water to swell in the presence of abundant water. The swelling properties of hydrogels are due to elasticity of the network, presence of hydrophilic functional groups (such as-COOH,-OH,-SO3H,-CONH2) in the polymer chains. The physiochemical properties, swelling studies and gelling capacity significantly govern the selection of hydrogel component. The development of hydrogels has received substantial consideration over past few years. This interest has been flickered by the advantages these advanced delivery system possess, which include modified, sustained and prolonged action, reduced dose, less side-effects, better drug utilization, better patient compliance, site specific drug targeting, protection of mucosa from irritation, prevention from general first pass metabolism .Non-steroidal anti-inflammatory drugs are mostly prescribed for the patients suffering from rheumatoid arthritis, osteoarthritis, soft tissue injuries, traumatic arthritis and other inflammatory disorders etc. Ibuprofen is non-steroidal anti-inflammatory drug (NSAID) which is anti-inflammatory, antipyretic and analgesic properties. It is chemically "2-(4-iso-butylphenyl)-propanoic acid" and is poorly soluble in water. It is mostly administered through oral route and is rapidly absorbed to reach its maximal plasma concentration within 2 hrs. It has a short biological half-life period of 2 hours, which means that numerous doses are required to maintain the therapeutic efficacy level over extended period of time. Frequent administrations of drug cause GIT side effects such as gastric ulceration, perforation and bleeding. pH sensitive hydrogel of ibuprofen attain a more modified & sustain release of the drug for long periods of time interval. Hence we can minimize the required dose and toxicity of the drug.

Exploring poly(vinyl alcohol) hydrogels containing drug–cyclodextrin complexes as controlled drug delivery systems

Journal of Applied Polymer Science, 2013

ABSTRACTPoly(vinyl alcohol) (PVA) hydrogels containing drug–β‐cyclodextrin inclusion complexes (ICs) were synthesized with glutaraldehyde (GA) as a crosslinker. The role of cyclodextrin (CD), the effect of the nature of drug, and the degree of crosslinking on the drug‐release process were investigated. The probable mechanism of drug release was also explored. Controlled release of the drug was achieved from the hydrogels containing the ICs. The nature of the drug, in terms of its binding efficacy with CD, played an important role. The effect of the degree of crosslinking on the release pattern was strikingly different from that in the hydrogels containing free drug and those with ICs. The role of CD in the drug‐release process was not only due to its inclusion ability but also its effect on the polymer relaxation. GA, apart from crosslinking PVA, probably interacted with the cyclodextrins and, thereby, influenced the matrix structure and the drug‐release kinetics. © 2013 Wiley Perio...

Release profile of ibuprofen in β-cyclodextrin complexes from two different solid dosage forms

Powder Technology, 2012

The objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with β-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass, the inclusion process occurred in a same yield that when pre-complexation was used. The particles characteristics were evaluated after being obtained through different complexation methods. The results showed that the tensile strength and profile dissolution were as expected for both dosage forms. Tablets containing inclusion complexes showed higher solubility when compared with a reference formulation and with two commercial formulations. The ibuprofen released from the two pellets formulations didn't show relevant differences between them. The drug released was analyzed considering different dissolution parameters. The advantages of these new methodologies can be summarized as: (a) tablets were produced at a lower cost for the total process; and (b) in the pellet´s preparation there was no need of the previous complexation method resulting in a decrease in time and energy required.

Synthesis and characterization of thermosensitive hydrogels and the investigation of modified release of ibuprofen

Hemijska industrija, 2013

The method of the synthesis of poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate) hydrogels obtained by radical polymerization is described. Their characterization was carried out by the determination of the quantity of residual monomers and by investigating their structure using FTIR. Three glass transitions were detected by DSC method. The porous surfaces of hydrogels with incorporated ibuprofen were shown in SEM micrographs. The swelling ratio of hydrogels decreased with the temperature increase and the swelling transport mechanism changed from non-Fickian to Fickian. Ibuprofen was incorporated in the hydrogel as a drug carrier and the released quantity depending on the temperature was monitored by HPLC. The hydrogel with the lower cross-linker content had the highest swelling degree (α = 34.72) at 10 C and released the largest amount of ibuprofen (64.21 mg/g xerogel ) at 40 C.

Australian Journal of Basic and Applied Sciences Corresponding Author: Slow Drug Release of Encapsulated Ibuprofen in Cross-linked Hydrogel for Tissue Engineering Application

Dication cross-linked gellan gum hydrogel loaded with Ibuprofen with excellent mechanical properties had been synthesized as potential candidate for non-toxic biocompatible polymer material in tissue engineering. The gellan gum hydrogel with 5% Ibuprofen had produced a slow release profile with total drug release time of 25 hours as a resulting low swelling value recorded at 22 + 0.5%. Its compressive strength, 200 + 21 kPa was highest of all other hydrogel ratio of 0.5% and 1.0% Ibuprofen incorporation. Young's Modulus of the hydrogel with 5% Ibuprofen was recorded at 1800 ± 10 kPa, indicating good gel strength in which it is capable of withstanding a fair amount of subjected force during topical wound dressing application. Excellent mechanical properties, together with slow release profile, make the ibuprofen-loaded hydrogel a prospect candidate as biocompatible extracellular matrices in wound management.

Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release

The Journal of Pure and Applied Chemistry Research, 2020

Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn has 489.21% swelling ratio and 81.67% gel. Ch/PVP/Alg crosslinked with formaldehyde result 488.03% swelling ratio and 85.34% gel. Dissolution test of hydrogels in pH 1.2 releases ibuprofen less than 30%. Whereas in the pH 7.4, the release of ibuprofen by hydrogels are relatively high. Ch/PVP/Alg/Ca reach up to 34.63% in 30 minutes and 40.86% for Ch/PVP/Alg/Zn. Meanwhile Ch/PVP/Alg/CH2O can release 44.92% of ibuprofen in 30 minutes. The obtained hydrogel was characterized using infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).

Poly(N-isopropylacrylamide) hydrogel: Effect of hydrophilicity on controlled release of ibuprofen at different pH

Journal of Applied Polymer Science, 2011

Stimuli-sensitive drug delivery systems (DDSs) have attracted considerable attention in medical and pharmaceutical fields; thermo-sensitive DDS dealing with poly(N-isopropylacrylamide) (PNIPAM) have been widely studied. Hydrogels composed of temperature-sensitive NIPAM and biocompatible and pH-sensitive maleic acid (MAc) were synthesized by sedimentation polymerization. Experiments on drug release from the crosslinked NIPAM-co-MAc hydrogel loaded with ibuprofen into different pH buffer solutions were successfully carried out at temperature swing between 25 and 40 C. The in vitro release studies have showed that the release rate depended on acidity or basicity (polarity) of the medium and the gel and swelling ratio of the gel network as a function of the environmental pH and temperature. The SEM image of the dry bead gave more insight into the surface architecture and the thermal studies shine light on the decomposition pattern and glass transition temperature of the gel. The mechanism of the drug release was discussed in relation to the diffusion rate and the abrupt change in the pH of the medium. V