Unravelling the aggregation behaviour and micellar properties of CHAPS (3-[(3-cholamidopropyl)-dimethylamino]-1-propanesulfonate), a zwitterionic derivative of cholic acid, using Coumarin 1 photophysics (original) (raw)

Journal of Photochemistry and Photobiology A: Chemistry, 2021

Abstract

Abstract The ever growing importance of colloids based on steroidal surfactants in diverse fields demands a comprehensive understanding of the self-assembly behaviour of these unconventional amphiphiles, which is less explored and poorly understood. Hence, a detailed investigation and a comparative analysis on the aggregation process of CHAPS (3-[(3-cholamidopropyl)-dimethylamino]-1-propanesulfonate), the zwitterionic derivative of cholic acid, and its bile salt analogues (cholates) is considered necessary for fundamental understanding and applications. In the present study, modulation in the photophysics of a small fluorescent molecule, Coumarin 1 has been utilised to get insight into the aggregation pattern and the micellar properties of CHAPS. Though CHAPS shares maximum homology with the cholates, yet its aggregation behaviour is more inclined towards that of the deoxycholates. It follows Small's model exhibiting some degree of criticalness, unlike the cholates, thus signifying the importance of the zwitterionic tail in the formation and stabilisation of the CHAPS micelles. The effect of salt concentration and temperature on the self-assembly process and micellar properties of CHAPS has been investigated. The effect of Sodium cholate and Sodium taurocholate as co-surfactants has also been monitored to understand the formation of mixed micelles. The various photophysical parameters reveal that CHAPS micelles offer a relatively more hydrophobic, compact and non-polar microenvironment to Coumarin 1 than the bile salts, indicating efficient packing of CHAPS molecules in the micelles. Owing to the superior nature of CHAPS aggregates and better shielding of guest molecules in the micelles, CHAPS based colloids could be promising candidates as potential delivery systems for biomedical applications.

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