Recent results in protein kinase inhibition for tropical diseases (original) (raw)
Chemical interrogation of the malaria kinome
Vanessa Luís
Chembiochem : a European journal of chemical biology, 2014
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Screening a protein kinase inhibitor library against Plasmodium falciparum
Irene Hallyburton
Malaria journal, 2017
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Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
Majida Bakkouri
PloS one, 2016
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Protein Kinases as Targets for Antiparasitic Chemotherapy Drugs
Rafael Caceres
Current Drug Targets, 2007
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Malaria: Targeting parasite and host cell kinomes
Christian Doerig
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
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Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases
Simona Collina
ChemMedChem
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New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource
Miguel Navarro
Scientific reports, 2015
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Identification of Potential Kinase Inhibitors within the PI3K/AKT Pathway of Leishmania Species
Florencia A. Castello
Biomolecules, 2021
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Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits
Kaira Tomaz
Frontiers in Chemistry
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The Akt- like kinase of Leishmania panamensis : As a new molecular target for drug discovery
Ruben Eduardo Varela Miranda
Acta Tropica, 2018
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Protein kinases of malaria parasites: an update
Christian Doerig
Trends in Parasitology, 2008
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Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors
A. Torrecilhas, Eric Dumonteil, Nir Qvit
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Parasite Protein Kinases: At Home and Abroad
Christian Doerig
Cell Host & Microbe, 2010
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A Kinase-focused Compound Collection: Compilation and Screening Strategy
Zhan Deng
Chemical Biology & Drug Design, 2006
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Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: Applications to protein kinase CK2
Laszlo Gyenis
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
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Using Existing Drugs as Leads for Broad Spectrum Anthelmintics Targeting Protein Kinases
Sahar Abubucker, Makedonka Mitreva
PLoS Pathogens, 2013
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Compounds from Natural Sources as Protein Kinase Inhibitors
Ryszard Szyszka
Biomolecules
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Natural Products as a Source of Chemical Diversity in cyclic-AMP dependent Protein Kinase A (PKA) Inhibitor Discovery
John Beutler
2023
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Protein kinase biochemistry and drug discovery
B. Murray
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High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors
J. Schwaller
Chemistry & Biology, 2011
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Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote
Christian Doerig
BMC genomics, 2004
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Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure–activity relationships with Trypanosoma brucei GSK-3
Alberto Napuli
Molecular and Biochemical Parasitology, 2011
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An enriched structural kinase database to enable kinome-wide structure-based analyses and drug discovery
R. Denny, Christine Humblet, Natasja Brooijmans
Protein Science, 2010
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Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk
Lucia Gerena, William Welsh
Bioorganic & Medicinal Chemistry Letters, 2007
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A Molecular Modeling Approach to Identify Potential Antileishmanial Compounds Against the Cell Division Cycle (cdc)-2-Related Kinase 12 (CRK12) Receptor of Leishmania donovani
Whelton Miller
Biomolecules
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Prospecting Biochemical Targets for in silico Study for Antileishmania Chemotherapy
Kayo Alves Figueiredo
Revista Virtual de Química
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In-silico Analyses of Natural Products on Leishmania Enzyme Targets
Hamilton Ishiki
Mini-Reviews in Medicinal Chemistry, 2015
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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
Haiching Ma
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Discovery of Potent Plasmodium falciparum Protein Kinase 6 (PfPK6) Inhibitors with a Type II Inhibitor Pharmacophore
Kareem Galal
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