Nanosuspension: a novel approach to enhance solubility of poorly water soluble drugs- A review (original) (raw)
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Nanosuspension As An Innovative Nanotechnology Trend Drug Delivery System: A Review
Systematic Reviews in Pharmacy, 2021
Solubility, the freedom of the drug from its route of administration, is the key factor for drug efficacy. Most of recently discovered drugs are insoluble in water and hence poorly absorbed with reduced bioavailability that lead to more production efforts. Due to their flexible characteristics and specific advantages, nanosuspensions has introduced as promising technique for effective hydrophilic drugs delivery. The reduction into the submicron range of drug particles leads to a major increase in rate dissolution and thus improves bioavailability of the drug. Nanosuspension involves colloidal dispersed submicron particles of the pharmaceutical active drug ingredient in liquid-phase stabilized with a surfactant. By oral and non-oral route of administration, nanosuspensions can be administered. Study focuses on different preparation methods with advantages and disadvantages, characterization techniques, and implementations.
Advances in Pharmacology and Pharmacy, 2023
The formulation development of a drug is majorly based on the solubility of drugs. Nearly 40% of newly developed drugs show poor water solubility. Several approaches are used for the increasing solubility of such drugs for formulation development. Nanosuspension is one such attractive tactic which can be used for the enhancement of solubility, stability as well as bioavailability of such drugs. Nanosuspension can be defined as a two-phasic dosage form where solid drug particles of size less than 1 μm are dispersed in an aqueous phase with the help of a stabilizer. Particle size reduction in the nanoscale causes an increase in the surface area leading to an increase in dissolution rate and ultimately bioavailability is increased. A variety of excipients are used for the formulation of nanosuspension. Stabilizers, surfactants, co-surfactants, natural as well as organic solvents, buffers, salts, polyols, osmogents, and cryoprotectants are used in the formulation of nanosuspension. Various methods used in the formulation of nanosuspension can be classified into top-down and bottom-up approaches. Wet milling, high-pressure homogenization, anti-solvent techniques, melt emulsification, supercritical fluid extraction and ultrasonic homogenization are some of the methods for the preparation of nanosuspension. These methods are easy and appropriate for all poor water-soluble drugs. Nanosuspensions technology can be applied for the preparation of oral, pulmonary, injectable, ocular as well as targeted drug delivery. This review emphasizes various advantages and disadvantages of nanosuspension, its methods of preparation, formulation approaches, evaluation parameters, pharmaceutical applications, marketed products and patents of nanosuspension.
Nanosuspension : Bioavailability Enhancing Novel Approach
2018
A Nanosuspension is a submicron colloidal dispersion of drug particles. The objective of this study to review on novel aspects of a novel dosage form Nanosuspension. A pharmaceutical nanosuspension is very finely colloid, Biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1 μm, without any matrix material, stabilized by surfactants and polymers, prepared by suitable methods for Drug Delivery applications, through various routes of administration like oral, topical, parenteral, ocular and pulmonary routes. An increase in saturation solubility is postulated by particle size reduction due to an increased dissolution pressure. Depending on the production technique applied changes in crystalline structure of drug particles may also occur. An increasing amount of amorphous drug fraction could induce higher saturation solubility. It was hypothesized that nanosuspensions will enhance drug flux resulting from higher trans-membranous concentration gradients. In nanosu...
The present article describes that how the nanosuspension technique is the most useful technique to deliver the drug having poor solubility. As we all know, that according to the BCS classification two and four most of the drug have poor solubility. Due to the poor solubility, these drugs are not absorbed well and have low bioavailability. To resolve this complication, many techniques are used such as micronization, use of penetration enhancers, use of solvent and co solvents etc. but those plans of action are most effectively beneficial for magnify the solubility of hydrophobic drugs. So, nanosuspension is the most effective method left which supply the medicine with better solubility and bioavailability. Utmost typically to prepare best nanosuspension formulations either media milling technique is used or if it is not employed then in place of this high-pressure homogenization technique gives the best result. In nanosuspension the drug are put up in dispersion and stabilizes via way of means of surfactants. This article, signifies how the nanosuspensions will prepared or what are the techniques employed to prepare best nanosuspensions formulation, secondaly it explains that if we prepared nanosuspensions then how we know that the nanosuspensions are actually prepared i.e characterization and at last this article explain how these nanosuspensions are deliver into our body i.e applications. Nanosuspension intensify now no longer simply the solubility however additionally the safety and efficacy of the drug. The nanosuspensions are deliver via oral route, transdermal route, parenteral route, pulmonary route, ocular route etc. Keywords: Nanosuspension technique, Solubility, Homogenization, BCS, Bioavailability.
Nanosuspensions: Ideal Approach for the Drug Delivery of Poorly Water Soluble Drugs
Der Pharmacia Lettre
Most of the drugs available to treat diseases are lipophilic in nature and challenging researchers to formulate them for a better bioavailablity. Out of all the approaches available nanosuspensions makes its way forward leading all other methods like cocrystals, microemulsions, liposomes etc. considering the advantages of nanosuspensions many attempts have been made to deliver poorly water soluble drugs as nanosuspensions prepared by adopting various methods. In this review, preparation methods, advantages of such methods, characterization of nanosuspensions, considerations and their applications have been reviewed hoping to make easy the future research in this area. Apart from the advancements till now, it scopes for further investigations in terms of pharmacokinetic and pharmacological correlations, invivo bioavailability studies and integration of physical chemistry, bio-informatics and biochemistry to study properties of nanosuspensions in detail.
Journal of Pharmaceutical Research International, 2022
Nanosuspension is a novel drug formulation for the delivery of hydrophobic drugs. The problem of medications that are poorly water-soluble and have low bioavailability is countered by nanosuspension technology. Solubility is a significant physiochemical element that influences drug absorption and therapeutic effectiveness. Poor aqueous solubility has the potential to impair formulation development. Nanosuspension technology can improve the drug's stability and bioavailability. Nanosuspensions can be formulated for various routes of administration such as oral, parenteral, ocular, topical, and pulmonary routes. Nanosuspension can be used for targeted drug delivery also by mucoadhesive gels and ocular inserts. Recent studies were approached to develop nanosuspension on site-specific drug delivery.
Current Pharma Research A Review on Nanosuspensionspromising Drug Delivery Strategy
Nanotechnology has emerged as a tremendous field in the medicine.Nano refers toparticles size range of 1-1000nm. Nanosuspensions are part of nanotechnology. Many of the drug candidates are exhibiting poor aqueous solubility. Solubility of a drug can be a limiting factor for its formulation into a suitable dosage form and it influences the effectiveness of a drug to a large extent. Nanosuspensions are defined as the sub-micron colloidal dispersions of pure drug particles stabilized by surfactants. Nanosuspensions differ from nanoparticles and solid lipid nanoparticles with respect to the fact that nanoparticles are polymeric colloidal carrier of drugs while SLN (solid-lipid nanoparticle) are lipidic carrier of drugs. Nanosuspensions can be successfully utilized for the delivery of poorly water soluble drug candidates. Formulation of lipophillic drugs into nanosuspensions improves their stability and also enhances their bioavailability significantly. Nanosuspensions have unique advantages for which they have been utilized for the production of dosage forms suitable for administration through oral, parenteral, ocular and pulmonary routes. Nanosuspensions can be manufactured using the 'Top Down' or 'Bottom's up' technology and employ a variety of components including surfactants for stability purposes and polymers for sustained release of drug in certain formulations.
Nanosuspension: A Novel Approach Toenhance Solubility of Poorly Watersoluble Drugs
Nanotechnology has emerged as a tremendous field in the medicine.Nano refers toparticles size range of 1-1000 nm. Nanosuspensions are part of nanotechnology. Many of the drug candidates are exhibiting poor aqueous solubility. The use of drugnanosuspension is a universal formulation approach to increase the therapeutic performance of these drugs in any route of administration. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion solvent evaporation, melt emulsification and supercritical fluid techniques. Nano-suspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels. This review article mainly focuses on preparation of nanosuspensions by various techniques with their advantages and disadvantages, formulation consid...
Nanosuspension: A Novel Drug Delivery System
International Journal of Pharmaceutical and Life Sciences, 2013
Low bioavailability is the major problem associated with poorly soluble drugs. The problem is more complex for drugs which are poorly soluble in both aqueous and nonaqueous media, as solubility is an essential factor for drug absorption, independent of the route of administration. Nanosuspensions have emerged as an attractive and promising approach to improve stability and bioavailability of poorly soluble drugs. These are very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1?m, without any matrix material, stabilized by surfactants and polymers. Techniques such as wet milling, high-pressure homogenization, emulsification-solvent evaporation and supercritical fluid have been used in the preparation of nanosuspension. Nanosuspension can be delivered by oral, parenteral, pulmonary and ocular routes. DOI: http://dx.doi.org/10.3329/ijpls.v2i4.17117 International Journal of Pharmaceutical and Life Sciences Volume 2, Issue 4: October 2013; 179-196
Nanosuspensions: A Strategy for Improved Bioavailability
2013
Poor aqueous solubility of lead drug candidates remains an obstacle for drug development in pharmaceutical industries. Drugs with dissolution rate limited drug absorption show low bioavailability due to poor aqueous solubility of the drug. To overcome these problems different formulations of nanosized drugs were developed recently. Pharmaceutical nanosuspensions consist of dispersed solid drug particles in an aqueous vehicle with average particle sizes below 1μm. The present paper is a review of current development in nanosuspension formulation strategies for possible improvement in oral bioavailability.