Molecular Pathology of Gastritis (original) (raw)
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Gastritis: Terminology, etiology, and clinicopathological correlations: Another biased view
Human Pathology, 1994
The histological approach to gastritis, especially the chronic forms, has undergone a series of re-evaluations by different experts over the past decade, mainly because of the recognition of individual disease patterns that have specific clinical and epidemiological implications. The most spectacular of these was the discovery of Helicobackrpylmi and its common gastritis, its relation to almost all duodenal peptic ulcers and to most gastric peptic ulcers, its potential as a precursor of first multifocal atrophic gastritis and later tubule-forming gastric carcinomas, and its status as a cause of gastric mucosal lymphomas. During this same decade other classes of gastric reaction and inflammations have been recognized, including chemical injury and lymphocytic gastritis. Also in the same decade the importance of non-steroidal anti-inflammatory drugs (NSAIDs) has emerged as a cause of gastric mucosal injuries. To add emphasis to all these discoveries, biopsies are being performed on stomachs in almost epidemic numbers and each biopsy specimen has the potential of having the features of one or more of these injuries as well as injuries that have yet to be described. To cope with tbis rapidly expanding gastric inflammatory informational extravaganza, pathologists need some way of dealing with the various entities comfortably and some method of cataloging them in ways that are understandable both to them and to the endoscopists with whom they work. However, if emerging data about the chronic gastritides are correct, it is conceivable that the need to diagnose them, from a strictly clinical standpoint, is limited. Either we may know what is in the biopsy specimen before we see it or what we see may not be important, although it may be intellectually challenging. HUM PATHOL 25:1006-1019.
Topography of gastritis and its severity in 864 first degree relatives of gastric cancer patients
Archives of Iranian medicine, 2011
Objectives: Studies on gastric mucosal histological ¿ndings among ¿rst degree relatives (FDR) of gastric cancer (GC) patients are scarce. The aim is to evaluate the topography and the severity of gastritis among FDR of GC patients. Design: A total of 989 subjects who were FDR of GC patients, ages 40-65 years underwent gastroscopies. When no gross lesion was found, ¿ve specimens were evaluated according to the Sydney Classi¿cation and one for urease testing in order to determine the type of gastritis and its severity. Results: Of the 989 subjects, 107 had signi¿cant lesions, including two with GC and one with esophageal cancer. The 864 subjects who had complete morphological data taken from ¿ve gastric areas (two from the antrum and three from the corpus) comprised 419 males (mean age 48.5±7 years) and 445 females (mean age 47±6.4 years). The H. pylori rate was 76.6%. Normal mucosa was seen in 6.9%, antrum-restricted gastritis in 7.4%, antrum-predominant gastritis in 63.5% and corpus-predominant gastritis in 20% (both had >80% H. pylori infection) and corpus-restricted gastritis in 2%. More atrophy was seen in the antrum and corpus of FDR females than males. The severity did not differ between those with one or more GC patients' relatives. Forty-nine percent of FDR had atrophy and 9.4% intestinal metaplasia (IM) in the corpus. After the age of 40, there was progression of intestinal metaplasia from 12.2 to 27.3% in the antrum and from 6.7% to 26.2% in the corpus during two decades. No high grade dysplasia was found in this mid-age population. Conclusion: Only one-¿fth of FDR have H. pylori-induced corpus-predominant gastritis who are at risk for cancer and suitable for eradication. Corpus-restricted gastritis is a rare disease in this area.
IP Innovative Publication Pvt. Ltd., 2017
Introduction: Helicobacter pylori(HP) infection is a major cause of various gastroduodenal pathologies. The objective of our study is to evaluate various histopathological parameters of chronic gastritis using the updated Sydney system and to correlate it with presence of HP. Materials and Method: Total 250 cases of chronic gastritis was evaluated retrospectively from January 2015 to December 2015 in a tertiary care centre. Histopathological examination of all antral gastric biopsies using Hematoxylin and Eosin, and Giemsa stain for grading of various parameters and for detection of HP was carried out. Result: Chronic inflammation was identified in 100% of cases with varying intensity. Intensity of activity showed an incremental trend with density of HP. Forty percent of cases with intestinal metaplasia showed the presence of HP. Atrophy was documented in only one case. A strong association between chronic inflammation, activity, intestinal metaplasia and lymphoid follicle with HP was established. Conclusion: The updated Sydney classification provides an objective mean of classifying chronic gastritis and increases the likelihood of detection of HP. Presence of intense grade of inflammation, activity and lymphoid follicle should hint the histopathologist to search for HP. And also the presence of one of these features is a strong indicator for the presence of the other.
Histopathological Characteristics of Atrophic Gastritis in Adult Population
Journal of Pharmacy and Pharmacology, 2015
Introduction: Chronic gastritis is inflammation of the gastric mucosa. It can be non-atrophic and atrophic. Atrophy is defined as the loss of appropriate glands. It is frequently located in antral mucosa as consequence of Helicobacter pylori infection and it is associated with intestinal gastric cancer. Goal: Describe histopathological and demographic characteristics of atrophic gastritis. Matherial and methods: We assessed the pathological reports of 100 patients with atrophic gastritis whose characteristics were evaluated by using a semiquantitative scale of Sidney system of classification of gastritis. To assess the significance between the incidence of various parametres we used χ 2 test. Results: We found that the difference in frequency of atrophic gastritis between men and women was not statistically significant. The difference in distribution is statistically significant in favor of the antrum. Among patients who have atrophy with Helicobacter pylori infection and intestinal metaplasia and those who do not have metaplasia, it was found that the difference is highly statistically significant. Conclusion: The most frequent localisation of atrophic gastritis is antral mucosa. There is no difference between men and women in frequency of atrophic gastritis, while the aging is related with more often occurrence of atrophic gastritis.
What is gastritis? What is gastropathy? How is it classified?
The Turkish Journal of Gastroenterology, 2014
Stomach endoscopic biopsies are made to determine the diagnosis of the illness, its stage, and follow-up after the treatment. It is very significant to collaborate with the clinician while evaluating endoscopic biopsies. Besides the clinical and laboratory information of the patient, the endoscopic appearance of the lesion should be known. The clinician and pathologist should use the same language and the same terminology. Although new classifications have been made to prevent the confusion of terminologies in neoplastic processes recently, most centers around the world have reported non-invasive neoplasias without giving any certain diagnosis by just commenting on it. The clinician should understand what the pathologist wants to say; pathologists should know the approach of the clinician (repetition of the biopsy, endoscopic resection, surgery). There is Helicobacter pylori (HP) in most of the stomach pathologies as the etiologic agent. No matter if the factor is HP or other etiologic agents, the tissue gives similar responses. That is why clinical-endoscopic indications should be taken into consideration, as well as histological indications, and the reports of the endoscopy should be seen. A good clinicopathologic correlation increases the accuracy of the diagnosis.