A review on Schiff base as a bioactive ligand (original) (raw)

Schiff bases are obtained from condensation of primary amines with carbonyl compounds. Schiff bases play an important role in inorganic chemistry due to formation of very stable complexes with various transition and inner-transition metals. There are several applications of Schiff bases in the field of biological activities which include antifungal, antimicrobial, antibacterial, anticancer, antioxidant, DNA cleavage, anti-inflammatory etc. Design of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. In this review article the biological applications of Schiff bases are summarized.