A review on Schiff base as a bioactive ligand (original) (raw)
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Performance of Schiff Bases Metal Complexes and their Ligand in Biological Activity: A Review
Al-Nahrain Journal of Science, 2021
Schiff bases are a broad class synthesized compound, which is prepared for the condensation process between the primary amine group and an aldehyde or ketone group. Schiff base metal complexes play an important role in many applications such as biological activity, catalytic activity, and optical property. The wide range application of Schiff base metal complexes came from the versatility of Schiff base reactions with many different transition metals. This flexibility of the reactions was given these complexes, many different properties and uses in a biological human system such as antibacterial, antifungal, anticancer, antimalarial, and others. This review gives many examples of Schiff bases, metal complexes, and there ligands with biological applications in the human system.
Biological Activities of Metal Complexes of Schiff Bases -A Review
Schiff bases have ability to form complexes with transition and inner transition metals and therefore regarded as very important class of organic compounds. Schiff bases serve as special ligands because they are readily synthesized by condensation reactions of aldehyde derivatives with imines. However their production is simple, their modest manufacturing technology and wide range of applications in areas such as coordination chemistry, analytical chemistry, catalysis and medicinal chemistry make them unique compounds. Various bioactivities such as anticancer, antineoplastic, analgesic, antifungal, antiviral, antioxidant, antibacterial, antipyretic, antiproliferative and anti-inflammatory etc. of schiff bases and their metal complexes are being studied. This review highlights synthesis as well as biological applications of various schiff bases and their metal complexes.
Biological Applications of Schiff base and its Metal Complexes-A Review
2014
Schiff Bases play an important role in Inorganic chemistry due to formation of very stable complexes with various transition and inner-Transition Metals. It has been extensively studied over past decades as Schiff bases provide potential sites for bio-chemically active compounds. This review is to summarize various Biological activities of Schiff Bases complexes as it has been recognized widely and Complexes may serve as biologically important species. Most of them show Biological activities such as antifungal, antibacterial, antimicrobial, and enzymatic activities.
Synthesis and bioactivity studies of novel Schiff bases and their complexes
Journal of Physical Organic Chemistry, 2019
The new Schiff base (L) "4-[(2,4-dimethoxy-benzylidene)-amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one" was synthesized from 2,4-dimethoxybenzaldehyde and 4-amino-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one, and the geometry of Schiff base was characterized and determined by proton nuclear magnetic resonance (1 H-NMR), mass, Fourier transform infrared (FT-IR), and ultraviolet-visible (UV-vis) spectroscopy. Schiff complexes of Ni(II), Pd(II), Pt(IV), Zn(II), Cd(II), and Mg(II) have been prepared by reaction of ion metals with as-prepared Schiff base. The results showed that synthesized complexes offered 1:2 metal-ligand ratios. Furthermore, the Schiff complexes were a tetrahedral in complexes Ni(II), Zn(II), Cd(II), and Hg(II), octahedral Pt(II), and square planer complex Pd(II). Additionally, density functional theory (DFT) was applied for calculations of both spectroscopic properties and electronic structure of prepared Schiff bases. Moreover, the Schiff base and its metal complexes have been verified in vitro against Streptococcus, Esherichia coli, Candida albicans, and Candida tropicalis in order to assess their antibacterial potential. The findings indicate that the biological activity augments on complexation reaction.
Oriental Journal Of Chemistry
Schiff based ligands and their complexes have emerged as potential drug candidates. Owing to their excellent chelating tendency, they easily coordinate with transition metals which have vacant orbitals. Transition metal complexes have several advantages because of their better acceptability and low toxicity in biological systems. These metals also serve as micronutrients and as co-factors of various metallo-enzymes which justifies the need of their designing and synthesis. Many modifications have been suggested in the ligand moiety for the purpose of activity enhancement and some of them have been described in the present review. These modifications have enhanced better potency against a number of diseases and resulting in low toxicity and better solubility in vivo. The transition metal complexes with Schiff based complexes have exhibited an array of activities including anticancer, antioxidant and antimicrobial. Their analytical applications have also been reported. The present rev...
Biological Importance of Schiff base Based Metal Complexes: A Brief Review
Journal of Scientific Enquiry, 2022
Schiff bases, generally synthesized by the condensation of aldehyde / ketone with primary amine, are imperative class of chelating ligands due to its coordination nature. In addition, Due to presence of imine group (-C=N), it shows various potential biological activities like antimicrobial, antifungal, antitumor, antiviral and anti-diabetic properties. Schiff base based metal complexes also exhibits potential applications in various fields such as magnetism, catalytic activity, sensing, biological activity, etc. Among the biological activity, till now Schiff base based metal complexes shows promising role as antibacterial, antifungal, antiviral, anticancer, antioxidant and anti-inflammatory agents. In this review we highlighted some Schiff base based metal complexes which attributed potential biological activity.
Application of Metal Complexes of Schiff Bases as an Antimicrobial Drug: A Review of Recent Works
International Journal of Current Pharmaceutical Research
Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scop...
REVIEW: Biomedical applications of Schiff base metal complexes
Journal of Coordination Chemistry, 2020
Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. For design and development of various bioactive compounds, Schiff bases carrying imine or azomethine (ÀC ¼ N-) functional group, are versatile pharmacophores. Medicinal chemists give attention toward new chemotherapeutic Schiff bases and their metal complexes owing to numerous applications in pharmacology as antiviral, antibacterial, antifungal, antimalarial, antituberculosis, anticancer, anti-HIV, anti-inflammatory, and antipyretic agents. This review highlights recently synthesized Schiff bases as well as their metal complexes as potential bioactive core.
Metal complexes of some transition metal ions viz Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) have been synthesized from a Schiff base (L) formed by the condensation of 3-amino-5-bromobenzofuran-2-carboxamide and 2-hydroxy-1-napthaldehyde. Synthesized compounds have been studied by various spectroscopic techniques and evaluated for their DNA cleavage and antimicrobial activities. Antibacterial activities of ligand and its metal complexes have shown that the metal complexes are more active than their corresponding ligand.
Biological applications of Schiff bases: An overview
GSC Biological and Pharmaceutical Sciences, 2022
Schiff bases are the compounds containing the azomethine group (-HC=N-). They are formed by the condensation of ketones or aldehydes with a primary amine. Formation of Schiff base generally takes place under acid/base catalysis or with heat. The common Schiff bases are crystalline solids, which are basic but at least some form insoluble salts with strong acids. Schiff bases are used as intermediates for the synthesis of amino acids or as ligands for the preparation of metal complexes having a series of different structures. The electrophilic carbon and nucleophilic nitrogen in the C=N imine bond provide excellent binding opportunities with different nucleophiles and electrophiles thereby inhibiting targeted diseases, enzymes or DNA replication. These Schiff bases are synthesized from various aldehydes and amines under stirring conditions, catalyst-free, reflux conditions, microwave irradiation and ultrasonic conditions. These compounds serve a wide range of applications in pharmaceutical industries as well as chemical industries. There are a series of biological activities exhibited by these compounds which include antimicrobial, anti-inflammatory, antiviral and antioxidant activities. Apart from exhibiting medicinal properties, Schiff base compounds play an important role as ligands in coordination chemistry. Thus, Schiff bases and their derivatives may be further used for enormous biological applications with potent effects.