Pectin-based (LA-co-MAA) semi-IPNS as a potential biomaterial for colonic delivery of oxaliplatin (original) (raw)

Gelatin-based hydrogels as potential biomaterials for colonic delivery of oxaliplatin

International Journal of Pharmaceutics, 2018

In present investigation, gelatin-based (AA-co-AMPS) hydrogels were prepared using N, N'-Methylenebisacrylamide (MBA) as a cross-linker and ammonium per sulfate (APS) as an initiator. The successful crosslinking and network formation was confirmed by Fourier transform infrared spectroscopy (FT IR). Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) investigations proved the higher thermal stability and successful entrapment of oxaliplatin (OXP) in the polymeric network. X-ray diffraction (XRD) confirmed the loss in crystallinity of the drug after loading in the hydrogel. Scanning electron microscopy (SEM) revealed the porous surface of the hydrogel. The newly formed hydrogels were responsive to change in pH. The swelling, drug loading and drug release was increased with increase in concentration of acrylic acid (AA) while gelatin and 2-acrylamido 2-methylpronesulfonic acid (AMPS) were found to act inversely. The in-vitro enzymatic degradation study showed that the blank hydrogels were more stable against the blank PBS than the collagenase and lysozyme. MTT-assay proved that the blank hydrogels were cyto-compatible while free OXP as well as OXP-loaded hydrogels showed dose dependent controlled cytotoxicity against Vero, MCF-7 and HCT-116 cell lines. The preliminary safety evaluation and oral tolerability showed that the hydrogel suspension was biocompatible and well tolerable upto 4000 mg/kg of body weight without causing any hematological or histopathological changes in rabbits.

As A Review on Hydrogels as Drug Delivery in the Pharmaceutical Field

Hydrogel is a network of polymer chains that are water-insoluble, sometimes found as a colloidal gel in which water is the dispersion medium. Hydrogels are crosslinked polymer networks that absorb substantial amounts of aqueous solutions. Due to their high water content, these gels resemble natural living tissue more than any other type of synthetic biomaterial. Several techniques have been reported for the synthesis of hydrogels like co polymerization/crosslinking of co-monomers using multifunctional co-monomer, which acts as crosslinking agent. Chemical initiator initiates the polymerization reaction. Some applications are used of hydrogels in human body. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosens...

Effect of Structural Properties of Hydrogel in Controlled Drug Delivery

2021

Hydrogels are extremely swollen, hydrophilic, three-dimensional polymer networks that are capable of absorbing vast amounts of body fluids or water. Hydrogels possess the ability to swell within their structure and hold a large fraction of water, but they may not dissolve in water. They have attracted tremendous attention as candidates for biomedical applications because of their ability to swell, under physiological conditions and their consequent biocompatibility. The ability of hydrogels to absorb large quantities of water is due to the presence of functional hydrophilic groups attached to their back bones or as lateral chains, whereas crosslinks between network chains result in their resistance to dissolution. Due to their specific physical properties, which make them promising materials for drug delivery, tissue engineering, and even in food and cosmetic manufacturing, they have attracted considerable attention in recent years. The interplay between their chemical-structure-property relationships and their interaction with the biological system, taking careful account of their physical, chemical, and biological properties, makes it possible to effectively design a hydrogel for biomedical applications. In this chapter, the structural parameters of polymer hydrogels and various drug release mechanisms of hydrogel drug delivery systems are discussed.

Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations

Pharmaceutics, 2022

Hydrogels are a promising and attractive option as polymeric gel networks, which have immensely fascinated researchers across the globe because of their outstanding characteristics such as elevated swellability, the permeability of oxygen at a high rate, good biocompatibility, easy loading, and drug release. Hydrogels have been extensively used for several purposes in the biomedical sector using versatile polymers of synthetic and natural origin. This review focuses on functional polymeric materials for the fabrication of hydrogels, evaluation of different parameters of biocompatibility and stability, and their application as carriers for drugs delivery, tissue engineering and other therapeutic purposes. The outcome of various studies on the use of hydrogels in different segments and how they have been appropriately altered in numerous ways to attain the desired targeted delivery of therapeutic agents is summarized. Patents and clinical trials conducted on hydrogel-based products, a...

Hydrogels Used As A Potential Drug Delivery System: A Review

International Journal of Pharmaceutical & Biological …, 2011

Hydrogels, the swellable polymeric materials have been widely investigated as the carrier for drug delivery systems. These biomaterials have gained attention owing to their peculiar characteristics like swelling in aqueous medium, pH and temperature sensitivity or sensitivity towards other stimuli. Hydrogels being biocompatible materials have been recognized to function as drug protectors, especially for peptides and proteins, from in-vivo environment. Also, these swollen polymers are helpful as targetable carriers for bioactive drugs with tissue specificity. Hydrogels are presently under investigation as a delivery system for bioactive molecules, because of their similar physical properties as that of living tissue, which is due to their high water content, soft and rubbery consistency, and low interfacial tension with water or biological fluids. This review presents an overview to the advances in hydrogel based drug delivery that have became the interest of most researchers.

Hydrogel: As Advance Drug Delivery System

2018

DOI: 10.21276/sjmps.2018.4.5.20 Abstract: Hydrogels have high affinity to absorb water due to the presence of hydrophilic group; Hydrogels can be prepared from both natural and synthetic polymer. Though the synthetic polymers are preferred more due to their less risk of immune response and less chances of viral and bacterial attack With increasing efforts devoted to controlled release of drug molecules, the application of hydrogels will continue to grow in future with its more relevantly and more efficiently applications, The success of hydrogels as delivery systems can be judged by several marketed preparations.

Hydrogel as drug delivery system

Research Journal of Pharmacy and Technology, 2012

The dissolution of a hydrophilic polymer in water can be prevented by adding cross-links via either a physical or a chemical process. A cross-linked hydrosol is called a hydrogel and swells in the surrounding liquid to a certain swelling ratio, depending on the number of cross-links, i.e., the cross-linking density. These hydrogels have many advantageous features including, stimuli responsive, good diffusion properties, low toxicity and good compatibility, Because of their chemical structures are similar to those of the bioactive Glycosoaminoglycan (GAG) molecules present in the extra-cellular matrix. Hydrogel preparation by freeze-thaw method involves physical cross-linking due to crystallite formation. This method does not require the presence of a cross-linking agent such physically cross-linked materials also exhibit higher mechanical strength than chemical or irradiative techniques. In Physical hydrogels, mechanical load can be distributed along the crystallites of the three dimensional structures. Extent crosslinking hydrogel analyzed by FTIR and DSC. The molecular transport phenomenon, as studied by the dynamic swelling experiments.

Hydrogels as Drug Delivery Systems; Pros and Cons

Trends in Pharmaceutical Sciences , 2019

Hydrogels are cross-linked polymers with hydrophilic groups which enable them to absorb large amounts of water. Although hydrogels have numerous capability and advantages in drug delivery including biocompatibility, low toxicity and good swelling behavior but depending on chemical moieties of the gel forming polymers and route of administration some limitations would appear in delivery of active pharmaceutical using hydrogel as delivery vehicle. In this review at first classification of the hydrogel with different approaches including chemical moieties, crosslinking agent behaviors and release controller mechanism was performed and limitations arise from each category was described and finally different approaches to overcome each of this limitation was proposed.

Hydrogels as drug-delivery platforms: physicochemical barriers and solutions

Therapeutic Delivery, 2012

The properties of hydrogels, in particular their high biocompatibility and water sorption uptake, make hydrogels very attractive in drug delivery and biomedical devices. These favorable features of hydrogels are compromised by certain structural limitations such as those associated with their low mechanical strength in the swollen state. This review highlights the most important challenges that may seriously affect the practical implementation of hydrogels in clinical practice and the solutions that may be applied to overcome these limitations.

Hydrogel based drug delivery system: A review

World Journal of Biology Pharmacy and Health Sciences

Hydrogels are the three-dimensional hydrophilic network which is crosslinked physically or chemically. Hydrogels are also called as hydrophilic gels because they absorb considerate amount of water. The characteristic properties of hydrogels are swelling, mechanical properties, biodegradable, elasticity, biocompatible, easy to modify, flexibility, etc. They are classified based on source, polymeric composition, biodegradability, configuration, cross linking, physical appearance, chemical charges, and drug release. Hydrogels can be synthesized from natural, synthetic, semisynthetic polymers via physical, chemical crosslinking, through grafting, coacervation and polymerization. The hydrogels are useful in daily life and their major applications are drug delivery to oral cavity, GI tract, rectal, ocular, protein, subcutaneous, transdermal, controlled drug delivery, preparation of contact lenses, wound healing, tissue engineering, biosensing, bacterial culture preparation, and various ot...