A novel conformation of gel grown biologically active cadmium nicotinate (original) (raw)
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Solid State Structures of Cadmium Complexes with Relevance for Biological Systems
Metal Ions in Life Sciences, 2012
This chapter reviews the literature on structural information from crystal structures determined by Xray diffractometry of cadmium(II) complexes containing ligands of potential biological interest. These ligands fall into three broad classes, (i) those containing N-donors such as purine or pyrimidine bases and derivatives of adenine, guanine or cytosine, (ii) those containing carboxylate groups such as αamino acids, in particular the twenty essential ones, the water soluble vitamins (B-complex) or the polycarboxylates of EDTA-like ligands, (iii) and those S-donors such as thiols/thiolates or dithiocarbamates. For some representative complexes of these ligands, a crystal and molecular structural analysis has been made, specifically addressing the coordination mode of ligands, the coordination environment of cadmium and, in some significant cases, the intermolecular interactions.
The crystal structures of two novel cadmium-picolinic acid complexes grown in aqueous solutions at selected pH values are reported. The structures are compared to expected solution species under the same conditions. The crystal structure of complex 1 exhibits a seven coordinate structure which contains a protonated picolinic acid ligand that bonds bidentately to the cadmium ion via both carboxylate oxygens. Two nitrates coordinate to the metal centre within the same plane, one monodentately and the other bidentately, and two water molecules are found in the axial positions. The structure of complex 2 shows cadmium bonded to three of N,O-bidentate picolinic acid ligands to produce a distorted octahedron.
International Journal of Scientific Research in Biological Sciences, 2019
Transition metal complex of Cd (II) with tetradentate schiff base derived from the condensation of 4-nitro-1,2diamino benzene and 5-nitro-salicyldehyde (H2L) have been synthesized. The synthesized square planar complex was investigated using elemental analysis (C, H and N), infrared, conductivity and electronic spectroscopic tools. The interactions of cadmium (II) complex examined towards Bovine serum albumin (BSA) with the help of absorption and fluorescence spectroscopic tools. The complex is strongly binds to proteins, then we study the antibacterial activity of the Schiff base and its cadmium complex by agar disc diffusion method against some species of pathogenic bacteria (Escherichia coli, Vibrio cholerae, Streptococcus pneumonia and Bacillus cereus).The result indicated that cadmium complex was more activity than ligand due to higher lipophilicity effect.
Inorganic and Nano-Metal Chemistry, 2016
A new long chain bidentate Schiff base ligand entitled was synthesized. Then four novel cadmium coordination compounds of this ligand were prepared. Schiff base ligand and its complexes were characterized by FT-IR, 1 H, 13 C NMR, UV-Vis spectra and molar conductance measurements. Based on spectral data, the general formula of CdLX 2 (X =Cl-, Br-, Iand SCN-) was proposed for the cadmium complexes. The cadmium compounds in nano-structure size were also prepared by sonochemical method. The nano-structure compounds were characterized by Xray diffraction (XRD) and scanning electron microscopy (SEM). The particle sizes were evaluated to be 28.04, 22.60, 11.30 and 31.85 nm, for cadmium chloride, bromide, iodide and thiocyanate complexes respectively. Moreover, CdO nanoparticles with average size about 26 nm were prepared and were characterized by XRD and transmission electron microscopy (TEM). Furthermore, the antimicrobial activity of the ligand and its cadmium complexes against four
Applied Organometallic Chemistry, 2010
One isomeric ligand, LC, among three isomers of 3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotet-radecanes (LA, LB and LC, differing in the orientation of methyl groups on the chiral carbon atoms), on reaction with Cd(NO3)2, CdCl2 and CdI2 produces octahedral cis-mononitrato nitrate, trans-dichloro and trans-diiodo cadmium(II) compounds of formulae cis-[CdLC(NO3)](NO3), trans-[CdLCCl2] and trans-[CdLCI2], respectively. The cis octahedral compound undergoes substitution reactions with KSCN, NaClO4 and KBr to form the trans-substitution products, trans-[CdLC(NCS)2], trans-[CdLC(ClO4)2] and trans-[CdLCBr2], respectively, whereby the bidentate NO3− ligand is replaced by two monodentate ligands that occupy axial positions. All compounds were characterized on the basis of analytical, spectroscopic, conductometric and magnetochemical data. The crystal structure of cis-CdLC(NO3)](NO3) was determined by X-ray crystallography and showed the cadmium centre to exist within a cis-N4O2 donor set that defined a distorted octahedral geometry. Non-systematic variations in the CdO and CdN bond distances were correlated with significant hydrogen bonding interactions operating in the crystal structure. The latter interactions led to the formation of supramolecular two-dimensional arrays. The anti-fungal and anti-bacterial activities of these compounds were studied against some phytopathogenic fungi and bacteria. Coordination of LC by cadmium resulted in more effective anti-microbial agents; no significant dependence upon the nature of the counter-ion was detected. Copyright © 2010 John Wiley & Sons, Ltd.
Polyhedron, 2017
Two new one-dimensional polymeric thiocyanato and selenocyanato bridged cadmium(II) complexes [Cd(dpip)(µ 1,3-SCN) 2 ] n and [Cd(dpip)(µ 1,3-SeCN) 2 ] n , where dpip = 3,5-dimethyl-1-((3-phenylimidazolidin-1-yl)-methyl)-1H-pyrazole have been synthesized and characterized by elemental analysis, IR, 1 H NMR and single crystal Xray diffraction studies. The bidentate N 2-coordinated ligand dpip is formed from N 4coordinated tetradentate ligand N,N-bis(3,5-dimethyl-1H-pyrazol-1-yl)methyl-N 2phenylethane-1,2-diamine (bdpab) due to unusual transformation, removing one pyrazole group and formation of saturated imidazole ring during in situ complexation reaction. The 1D structures of the two complexes have been confirmed by single crystal X-ray diffraction studies and both NCSand NCSeact as end-to-end (µ-1,3) bridging ligands. The coordination environment around the cadmium center in the complexes are CdN 4 S 2 and CdN 4 Se 2, respectively and each cadmium(II) center has distorted octahedral geometry. The distortion in the molecules are due to two unequal Cd-N (organic ligand dpip) bond lengths and small bite angel of the unsymmetrical organic ligand. The DFT calculations performed with cadmium(II) complexes [Cd(dpip)(µ 1,3-SCN) 2 ] n and [Cd(dpip)(µ 1,3-SeCN) 2 ] n corroborated the observed crystal structures and the structural parameter were found to be in good agreement in both calculated and X-ray geometries.
Journal of Saudi Chemical Society, 2017
The photophysical properties of luminescent tetra-coordinated cadmium (II) complex formulated as [Cd(L)Cl],HL = (1-[(3-methyl-pyridine-2-ylimino)-methyl]-naphthalen-2-ol) were synthesized and characterized by analytical and spectroscopic methods. The density function theory calculations are used to investigate the electronic structures of the ligand and its complex. The interactions of cadmium (II) complex towards bovine serum albumin (BSA) and human serum albumin (HSA) were investigated using absorption and fluorescence spectroscopic techniques at pH 7.4. The quenching constants, binding constants and number of binding sites were determined by fluorescence quenching method. The calculated thermodynamic parameters (DG, DH, and DS) confirmed that the binding reaction is mainly entropy-driven and hydrophobic forces played an important role in the reaction. Here, we proposed a new synthetic procedure for the preparation of BSA and HSA with cadmium complex nanowires. The scanning electron microscopy images show that BSA and HSA with cadmium complex product are wire-like in structure. The complex shows enhanced antibacterial activity compared with the free ligand and standard antibiotic chloramphenicol. Antioxidant studies showed that the complex has significant antioxidant activity against DPPH.
Bioinorganic Chemistry and Applications, 2010
The reaction of N, N-bis(2-hydroxyethyl)glycine (bicine; bicH 3 ) with Cd(O 2 CPh) 2 · 2H 2 O in MeOH yielded the polymeric compound [Cd 2 (O 2 CPh) 2 (bicH 2 ) 2 ] n (1). The complex crystallizes in the tetragonal space group P4 1 2 1 2. The lattice constants are a = b = 12.737(5) and c = 18.288(7)Å. The compound contains chains of repeating {Cd 2 (O 2 CPh) 2 (bicH 2 ) 2 } units. One Cd II atom is coordinated by two carboxylate oxygen, four hydroxyl oxygen, and two nitrogen atoms from two symmetryrelated 2.21111 (Harris notation) bicH 2 − ligands. The other Cd II atom is coordinated by six carboxylate oxygen atoms, four from two bicH 2 − ligands and two from the monodentate benzoate groups. Each bicinate(-1) ligand chelates the 8-coordinate, square antiprismatic Cd II atom through one carboxylate oxygen, the nitrogen, and both hydroxyl oxygen atoms and bridges the second, six-coordinate trigonal prismatic Cd II center through its carboxylate oxygen atoms. Compound 1 is the first structurally characterized cadmium(II) complex containing any anionic form of bicine as ligand. IR data of 1 are discussed in terms of the coordination modes of the ligands and the known structure.