Structure of the TAR/1 complex (original) (raw)

2011

Abstract

<b>Copyright information:</b>Taken from "TAR-RNA recognition by a novel cyclic aminoglycoside analogue"Nucleic Acids Research 2006;34(12):3599-3608.Published online 19 Jul 2006PMCID:PMC1524922.© 2006 The Author(s) () Superposition of the heavy atoms of 14 structures of the TAR/ complex based upon residues 16–21, 26–29 and 36–46. These structures had total energy 0.5 Å and no angular violations. Residues 30–35 and the bases of U23/U25 are not shown. The lower stem is colored in blue and the upper stem in green. A22 and U40 are highlighted in orange; the backbone of the bulge is in magenta. The backbone and the base stacking indicate that the upper and lower stems form an angle of ∼60°. The aminoglycoside binding to the major groove of the HIV-2 TAR-RNA upper stem is rendered in gray. () Same ensemble as in (A) after 180° rotation around the vertical axis. The ligand is not shown.

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