β-Catenin and matrix metalloproteinase-7 expression in deep fibromatosis (original) (raw)

Egyptian Journal of Pathology, 2012

Abstract

ABSTRACT Background: Deep (aggressive) fibromatoses (desmoid tumours) are locally aggressive soft tissue tumours associated with the adenomatous polyposis coli-β-catenin-signalling pathway. Matrix metalloproteinase-7 (MMP-7), which is one of the target genes of the adenomatous polyposis coli-β-catenin-signalling pathway, has been reported to play an important role in tumour progression. In this study, we studied the expression of nuclear β-catenin and MMP-7 in deep fibromatosis and examined their relationship with early recurrence. Materials and methods: The study was carried out on 26 patients with fibromatosis during the period from January 2000 to January 2010 at the clinical oncology and nuclear medicine department, Mansoura University, Egypt. Archival materials were obtained from the pathology department and other laboratories. Paraffin sections of all samples were submitted for immunohistochemistry using β-catenin and MMP-7, with subsequent retrospective analysis of clinical data for all patients and β-catenin and MMP-7 in relation to recurrence. Results: Nuclear β-catenin was expressed in all cases, either focal or diffuse; MMP-7 was expressed in 22 cases with variable intensity and distribution from mild, moderate to marked. Positive expression of β-catenin and MMP-7 was significantly associated with early recurrence (P<0.05). There was a statistically significant correlation between the widespread nuclear expression of β-catenin and overexpression of MMP-7 (P<0.01). Adjuvant radiotherapy showed a negative correlation with early recurrence, but unfortunately, was not statistically significant (P=0.024), whereas sex, age, positive margins and tumour site were not statistically significant (P>0.01). Conclusion: β-Catenin and MMP-7 expression were associated with higher early local recurrence and could be a potential predictive factor for recurrence or aggressive behaviour. Therefore, both could define a subset of patients with aggressive behaviour and who may benefit from a combined modality such as surgery and postoperative radiotherapy.

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