Sensitive metal layer assisted guided mode resonance biosensor with a spectrum inversed response and strong asymmetric resonance field distribution (original) (raw)
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Biosensors, 2021
Guided-mode resonance (GMR) sensors are widely used as biosensors with the advantages of simple structure, easy detection schemes, high efficiency, and narrow linewidth. However, their applications are limited by their relatively low sensitivity (<200 nm/RIU) and in turn low figure of merit (FOM, <100 1/RIU). Many efforts have been made to enhance the sensitivity or FOM, separately. To enhance the sensitivity and FOM simultaneously for more sensitive sensing, we proposed a metal layer-assisted double-grating (MADG) structure with the evanescent field extending to the sensing region enabled by the metal reflector layer underneath the double-grating. The influence of structural parameters was systematically investigated. Bulk sensitivity of 550.0 nm/RIU and FOM of 1571.4 1/RIU were obtained after numerical optimization. Compared with a single-grating structure, the surface sensitivity of the double-grating structure for protein adsorption increases by a factor of 2.4 times. The ...
Multiparametric Guided-Mode Resonance Biosensor Monitoring Bulk and Surface-Film Variations
Chemosensors
A guided-mode resonance (GMR) sensor with multiple resonant modes is used to measure the collection of biomolecules on the sensor surface and the index of refraction of the sensor environment (bulk). The number of sensor variables that can be monitored (biolayer index of refraction, biolayer thickness, and bulk, or background, index of refraction) is determined by the number of supported resonant modes that are sensitive to changes in these variable values. The sensor we use has a grating and homogeneous layer, both of which are made of silicon nitride (Si3N4), on a quartz substrate. In this work, we simulate the sensor reflection response as a biolayer grows on the sensor surface at thicknesses from 0 to 20 nm and biolayer indices of refraction from 1.334 to 1.43 RIU; simultaneously, we vary the bulk index of refraction from 1.334 to 1.43 RIU. In the specified span of sensor variable values, the resonance wavelength shifts for 2023 permutations of the biolayer index of refraction, ...
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