Enzymatic Wound Debridement; Role of Papaya in the Management of Post Cesarean Gaped Wounds (original) (raw)
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Role of Topical Papaya Application in Debridement of Deep Burn Wounds
Journal of Rawalpindi Medical College, 2021
Objective: To study the role of topical papaya application in managing deep burn wounds in terms of proteolytic enzymatic debridement for wound bed preparation.Material and Methods: This was a descriptive study carried out at Rawalian burn centre holy family hospital Pakistan from 12-10-2019 to 11-1-2020 over a period of 03 months. A total of 30 patients were included in the study (n=30). A convenient non-probability sampling technique was used for allocating patients to the study after getting written informed consent. For patients included in the study, papaya dressing was used for debridement and wound bed preparation of deep burn wounds.Results: There were 19 (63.3%) female and 11 (36.7%) male patients. The age range of patients was 10y to 50y with a mean of 28 years and SD ± 8.06 Patients included in the study had TBSA ranging from 10% to 35% with a mean of 19.8% and SD ± 6.82%. On average 7 dressings (Range 5-7) were required to achieve pink healthy granulation tissue. Out of ...
Complementary Therapies in Clinical Practice, 2019
Background: and purpose: Complications of the delayed recovery of cesarean section (CS) wound can include stress, discomfort, and dissatisfaction of the mother in the postpartum period. This study tried to determine the effect of grape seed extract ointment on CS wound healing. Materials and methods: This is a double-blind, randomized, controlled clinical trial incorporating 129 women eligible for CS in eastern Iran. Participants were selected through convenience sampling method and were subsequently randomly assigned into three groups: 2.5% grape seed extract ointment, 5% grape seed extract ointment, and petrolatum. CS wound healing indices were assessed before the intervention, and 6 and 14 days after the intervention using the REEDA scale (redness, edema, ecchymosis, discharge, and approximation). Results: The mean scores on days 6 and 14 after intervention were respectively 2.02 ± 0.52 and 0.98 ± 0.61 in the 5% ointment group, 2.83 ± 0.54 and 1.58 ± 0.67 in the 2.5% ointment group, and 2.91 ± 0.51 and 1.55 ± 0.74 in the petrolatum group. While the mean score in the 5% ointment group was significantly different from those of 2.5% ointment and petrolatum groups (P < 0.001), the mean score in the 2.5% ointment group was not significantly different from that of the petrolatum group on days 6 and 14 after intervention (P = 0.38 and P = 0.79, respectively). Conclusion: The current results suggest that 5% grape seed extract may have beneficial therapeutic effects in promoting CS wound healing.
THE WOUND HEALING EFFECT OF POWDERED CARICA PAPAYA LEAVE
Carica papaya has been investigated in treatments of ulcers and wounds especially in developing countries. This study was aimed at investigating the wound healing efficiency of powdered Carica papaya leave. Wistar rats were divided into 3 groups: Group 1(control): Treated with normal saline. Group 2 (control check): Treated with propylene glycol alone, Group 3 (experimental): Treated with powdered Carica papaya leave. Wound was inflicted and dressed with normal saline; propylene glycol and powdered Carica papaya leave respectively. The efficacy of treatment was assessed by the rate of wound closure, Wound contraction, fibroblast cell count and histology of granulation tissue. The result showed an insignificant difference in wound contraction (P> 0.05). Significant difference in wound closure was observed with group 3 been the fastest (P< 0.05). Fibroblast cell count showed statistical significant difference among the groups and across days (P< 0.05). Scar tissue also showed significant difference in fibroblast cell counts (P< 0.05). In conclusion, our study gave scientific background for the use powdered Carica papaya leave as a potential wound healing agent which is potent and faster in wound healing as against papaya extracts and normal saline among Wistar rats. It has also documented that propylene glycol has an enhancing therapeutic property in the wound healing process among Wistar rats.
The Role of Papaya Dressings in the Management of Diabetic Foot Ulcers: A Prospective Study
2015
OBJECTIVES: To determine the role of grated papaya fruit dressings in the management of diabetic foot ulcers. STUDY DESIGN: In our study, all the patients with diabetic foot ulcers (n=94) were included. The initial management was control of hyperglycemia, surgical debridement, antibiotics and then wound care with the help of grated papaya dressings. In this study, dressings were changed every 24 hours. The wound was considered healthy, when it was covered with healthy granulation tissue and had epithelial growth on wound edges. RESULTS: In this study, results reveal that majority (83.0%) of the patients were male. Among them, surgical debridement was done for sixty three patients (67.2%) and thirty one patients (33.8%) required amputation. After the initial surgical debridement papaya dressings were needed in about 89.0%. Six patients (7%) needed further surgical debridement and four (4.0%) required amputations. Duration of healing was 17 to 28 days. Mean healing period was 21.56 da...
Wound-healing potential of an ethanol extract of Carica papaya (Caricaceae) seeds
International Wound Journal, 2012
Carica papaya L. (Linn) (Caricaceae) is traditionally used to treat various skin disorders, including wounds. It is widely used in developing countries as an effective and readily available treatment for various wounds, particularly burns. This study evaluated the wound-healing and antimicrobial activity of C. papaya seed extract. Ethanol extract of C. papaya seed (50 mg/kg/day) was evaluated for its wound-healing activity in Sprague-Dawley rats using excision wound model. Animals were randomly divided into four groups of six each (group 1 served as control, group 2 treated with papaya seed extract, group 3 treated with a standard drug mupirocin and papaya seed extract (1:1 ratio) and group 4 treated with a mupirocin ointment. Rate of wound contraction and hydroxyproline content were determined to assess the wound-healing activity of the seed extract. The group 2 animals showed a significant decrease in wound area of 89% over 13 days when compared with groups 1 (82%), 3 (86%) and 4 (84%) respectively. The hydroxyproline content was significantly higher with the granulation tissue obtained from group 2 animals which were treated with C. papaya seed extract. Histological analysis of granulation tissue of the group 2 animals showed the deposition of well-organized collagen. The extract exhibited antimicrobial activity against Salmonella choleraesuis and Staphylococcus aureus. Our results suggest that C. papaya promotes significant wound healing in rats and further evaluation for this activity in humans is suggested.
Wound Bed Preparation Using Unripe Pawpaw in a Resource Poor Environment: A Prospective Study
WORLD JOURNAL OF PLASTIC SURGERY, 2022
BACKGROUND Chronic wounds affect mainly the productive age group in developing countries and stretch the limited healthcare facility. We aimed to establish the efficacy or otherwise of pawpaw dressing in management of common forms of wounds in resource-poor settings using the Nigerian pawpaw in humans. METHODS This study was a prospective research carried out at Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria between September 2019 and August 2020 using patients with lower extremity wounds. Thirty patients who had lower extremity wounds that required debridement were enrolled in the study after giving consent. They had wound dressing with unripe pawpaw as an enzymatic debriding agent to evaluate the rapidity of eschar separation and bacterial clearance. The data obtained with a proforma were analyzed using IBM SPSS. RESULTS There were 16 males and 14 females with an average wound size of 127.13+ 103cm2. Eschar separation occurred earliest after 3 d of dressing and the latest after 14 d with a mean period of 5.5+ 2.255 days. A case had negative bacterial culture on the first test. Others had a variable period of clearance with a maximum of 18 d and a mean of 6.73+3.750 days. Both eschar separation and bacterial clearance correlated positively with the wound size. CONCLUSION Wound bed preparation with unripe pawpaw dressing showed promising outcomes with rapid eschar and slough separation, and bacterial clearance resulting in a faster wound healing. This is recommended for wounds needing debridement in which the patients are not fit for anesthesia or could not afford the cost of surgery.
Evidence-Based Complementary and Alternative Medicine
Wound healing entails a sequence of complex biological processes, which is a protective function of the body that focuses on a quick recovery. Reducing wound healing time is crucial in a wound as it lowers the chance of infection and decreases complications and costs. Papaya extract was obtained by a maceration method. It contains papain enzyme, flavonoid, saponin, and alkaloid, which act as an anti-inflammatory, astringent substance, vasodilator, antioxidant, analgesic, with antifungal, and antibacterial properties, and increase the collagen synthesis. This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice (Mus musculus) clinically and histologically. This experimental laboratory study was performed using 24 mice weighing between 30 and 40 grams and 12 and 14 weeks of age as experimental animals. Each group was incised along 5 mm at the labial gingiva under both of mandible anterior teeth with a depth reaching alveola...
Effectiveness of using the gel of papain in the wound healing: clinical trial
Online Brazilian Journal of Nursing, 2011
Currently considered chronic wounds public health problem due to the large number of events, the high costs of treatment and their impact on the quality of life of the patient. This clinical trial evaluating the effectuation wants the use of papain gel in the healing process of leg, contributing through the evidence found to update the knowledge of nurses and nursing students and providing a basis for decision-making and other research scientific.
Management of Non-Healing Ulcer by the Use of Crushed Raw Papaya along with Leeching: A Case Study
Journal of Drug Delivery and Therapeutics, 2021
The incidence of non-healing ulcer is 1-2 percent in developed countries. In Indian community its prevalence reported in year 2004 was 4.8 per 1000 populations. It may increase many folds in future because of increase in number of old persons, diabetes mellitus and vascular diseases A male patient aged 63yrs. came to surgery OPD Majeedia Unani Hospital, Jamia Hamdard, New Delhi, in October 2019, with the complain of ulcer on antero-medial aspect of right foot. The ulcer was painful and movement was limited on affected side. After required investigations and local examination of wound, treatment was started by local application of meshed papaya and combination of oral Unani drugs formulations along with leech therapy as described in texts of Unani System of Medicine. It was observed that Unani treatment of non-healing ulcer with papaya and leech therapy is an option to avoid amputation and its complications. The ulcer completely healed without any locomotor disturbances. Recovery wa...
Comparison of Honey Dressing with Povidone-iodine dressing in Infected Surgical Wounds
2019
Background: Honey is a type of natural dressing with many mechanical, biochemical and antimicrobial properties. Aim: To prove that Honey is better than conventional dressing with Povidone-Iodine (PVI) in terms of pain control and wound healing. Methods: It is a randomized, single blind and multicentre experimental study, carried out in 2 hospitals i.e., Bhatti International Teaching Hospital situated in Kasur and Noor Hospital situated in Kot Radha Kishan from 04-05-18 to 10-01-19. 105 patients were included in the study while 2 patients left the follow up during study period. 2 parameters were studied i.e. Pain control and wound healing. Pain is assessed by visual analogue scale (VAS) and wound healing was assessed in terms of resolution of erythema and resolution of discharge from the wound. Results: Mean age of patients in Honey dressing (HD) group was 42±12 years while mean age of patients in PVI dressing (PD) group was 40±13 years. 75% of patients from HD group were male while ...