Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins (original) (raw)
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Low birth weight, prematurity and higher miscarriage rates prematurity and higher miscarriage rates have previously been reported in women have previously been reported in women with eating disorders. with eating disorders. Aims Aims To determine whether women To determine whether women with a history of eating disorders are at with a history of eating disorders are at higher risk of major adverse perinatal higher riskof major adverse perinatal outcomes. outcomes. Methods Methods Adjusted birth weight, Adjusted birth weight, preterm delivery and miscarriage history preterm delivery and miscarriage history were compared in those with a history of were compared in those with a history of eating disorders (anorexia nervosa eating disorders (anorexia nervosa (
The International journal of eating disorders, 2010
Research shows a significant association between eating disorders (ED) and substance use disorders (SUD). The objective of this study is to examine the prevalence, chronology, and possibility of shared familial risk between SUD and ED symptomatology. Subjects included 1,206 monozygotic and 877 dizygotic adult female twins. ED symptomatology included anorexia (AN) and bulimia nervosa (BN) diagnosis, symptoms associated with diagnostic criteria, and BN symptom count. SUD included alcohol, illicit drug, and caffeine abuse/dependence. Generalized estimated equation modeling was used to examine phenotypic associations, and Choleksy decompositions were used to delineate the contribution of genes and environment to comorbidity. There were no significant differences between SUD prevalence in women with AN and BN. Women with BN reported BN preceded SUD development while the reverse was true for AN. Twin analyses showed possible familial overlap between BN symptomatology and all SUD examined....
Journal of Abnormal Psychology, 2017
Previous research suggests that maternal eating disorders are associated with adverse pregnancy, delivery, and neonatal outcomes. In turn, adverse perinatal outcomes have been associated with subsequent eating disorder risk in adult offspring, possibly reflecting a transgenerational cycle of risk. Previous studies of the relationship between maternal eating disorders and adverse perinatal outcomes have failed to control for familial transmission of perinatal event phenotypes, which may confound the association. In a unique design afforded by the Norwegian Mother and Child Cohort Study (MoBa) and Medical Birth Registry of Norway, we linked three generations through birth register records and maternal-reported survey data. The aim was to determine if maternal eating disorders increase risk after parsing out the contribution of familial transmission of perinatal events. The samples were 70,881 pregnancies in grandmother-mother-child triads for analyses concerning eating disorder exposure during pregnancy and 52,348 for analyses concerning lifetime maternal eating disorder exposure. As hypothesized, eating disorders predicted a higher incidence of perinatal complications even after adjusting for grandmaternal perinatal events. For example, anorexia nervosa immediately prior to pregnancy was associated with smaller birth length (relative risk = 1.62, 95% confidence interval = 1.20, 2.14), bulimia nervosa with induced labor (1.21; 1.07, 1.36), and binge-eating disorder with several delivery complications, larger birth length (1.25; 1.17, 1.34), and large-for-gestational-age (1.04; 1.01, 1.06). Maternal pregravid body mass index and gestational weight mediated most associations. Our results support the contention that exposure to eating disorders increases the risk for negative health outcomes in pregnant women and their babies.
Obstetric and Perinatal Outcomes in Women with Eating Disorders
Journal of Women's Health, 2012
Background: We wished to investigate whether women with a history of eating disorders have an increased risk for adverse obstetric and perinatal outcomes. Study design: A retrospective study was conducted comparing pregnancy complications in patients with and without eating disorders. Deliveries occurred during the years 1988-2009 in a tertiary medical center. Women lacking prenatal care and with multiple gestations were excluded from the study. Stratified analyses were performed using multivariable logistic regression models. Odds ratios (OR) and their 95% confidence interval (CI) were computed. A p value < 0.05 was considered statistically significant. Results: During the study period, of 117,875 singleton deliveries, 122 (0.1%) occurred in patients with eating disorders. Eating disorders were significantly associated with fertility treatments (5.7% vs. 2.8%, p = 0.047), intrauterine growth restriction (7.4% vs. 2.3%, p < 0.001), term low birth weight ( < 2500g) (7.4% vs. 2.8%, p = 0.002), preterm delivery (15.6% vs. 7.5%, p = 0.002), and cesarean delivery (25.4% vs. 15.0%, p = 0.001). Using multivariable analyses, low birth weight (OR 2.5, 95% CI 1.3-5.0), preterm delivery (OR 2.2, 95% CI 1.4-3.6), and cesarean section (OR 1.9, 95% CI 1.3-2.9) were significantly associated with eating disorders. Conclusions: Eating disorders are associated with increased risk of adverse pregnancy outcomes. Accordingly, careful surveillance is needed for early detection of possible complications.
Psychiatric Genetics, 2000
The study of discordant monozygotic twins may identify important developmental risk factors for adult psychiatric disorder. Differential experience in utero is one candidate environmental risk factor that may distinguish monozygotic twins. In this report, we examine whether intra-pair differences in birth weight predicts discordance for adult psychiatric disorders in 527 female monozygotic twin pairs from a population-based twin registry. Twins were personally interviewed about their lifetime history of DSM-III-R alcoholism, anorexia nervosa, bulimia nervosa, generalized anxiety disorder, major depression, panic disorder, social phobia and simple phobia. Birth weight was estimated from birth certificates, or from retrospective maternal, paternal and self-reports. Conditional logistic regression is used to characterize the association between intra-pair differences in birth weight and discordance for psychiatric disorder in monozygotic twins.
European Eating Disorders Review, 2014
This study aims to investigate longitudinal patterns of psychopathology during the antenatal and postnatal periods among women with current (C-ED) and past (P-ED) eating disorders. Women were recruited to a prospective longitudinal study: C-ED (n = 31), P-ED (n = 29) and healthy control (HC; n = 57). Anxiety, depression and ED symptoms were measured at four time points: first/second trimester, third trimester, 8 weeks and 6 months postpartum. Linear mixed effects models were used to test for group differences. Women with C-ED and P-ED, in all diagnostic categories, had significantly higher levels of psychopathology at all time points. ED symptoms decreased in the C-ED group, compared with an overall increase in the other two groups but subsequently increased after pregnancy. Overall, depression and state and trait anxiety scores decreased in the C-ED group compared with the HC group throughout the antenatal and postnatal periods. High levels of psychopathology are common throughout the antenatal and postnatal periods among women with current and past ED, and despite some overall reductions, symptoms remain clinically significant.
Pregnancy, obstetric, and perinatal health outcomes in eating disorders
American Journal of Obstetrics and Gynecology, 2014
Authors JTS and JMS have been involved in a research collaboration with Janssen-Cilag. Author JTS has received fees for giving expert opinions to Lightlake Sinclair and attended one international conference supported by Janssen-Cilag. Author JMS has received a lecturing fee from AstraZeneca. Author JH has been in research collaboration with Janssen-Cilag and Eli Lilly, and has been a member of the expert advisory group for Astellas. Author AR attended a medical seminar supported by Janssen-Cilag. Authors ML and MG have no conflicts of interest to report.