Insomnia is not associated with substancial structural brain changes (In press.) (original) (raw)

2012

Abstract

Study Objectives: Sleep has been demonstrated to significantly modulate brain plasticity and the manifestation of mental disorders. However, previous studies on the impact of disrupted sleep on brain structure have reported inconsistent results. The current study aimed at investigating brain morphometry in a well-characterized large sample of primary insomnia (PI) patients in comparison to good sleeper controls. Design: Automated parcellation and pattern recognition approaches were supplemented by voxel-wise analyses of gray and white matter volumes to analyze MR images. All analyses included age, sex, and total intracranial volume as covariates. Setting: Department of Psychiatry and Psychotherapy of the University of Freiburg Medical Center. Participants: 28 PI patients (10 males; 18 females; 43.7 ± 14.2 years) and 38 healthy good sleepers (17 males; 21 females; 39.6 ± 8.9 years). Interventions: N/A Results: No significant between-group differences were observed in any of the investigated brain morphometry variables. Conclusions: Altered brain function in insomnia does not seem to have a substantial impact on brain morphometry on a macroscopic level

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