Hippocampal and medial prefrontal cortical volume is associated with overnight declarative memory consolidation independent of specific sleep oscillations (original) (raw)
2020, Journal of Sleep Research
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Relationship between sleep structure, memory and size of the hippocampus
Alzheimer's & Dementia
BackgroundSleep is important for consolidating declarative memory. Hippocampus is considered an important structure in this process. Our goal was to assess relationship between sleep structure, memory and size of the hippocampus.Method18 patients (4 men, age range 60 ‐ 80 years) underwent polysomnography, neuropsychological examination and brain MRI (3 T). Sleep efficiency, percentages of REM and non‐REM sleep stages were calculated. Delayed recall score in Rey Auditory Verbal Learning Test (RAVLT) was used to assess memory. Size of the hippocampus was evaluated using MRI visual scale named Hip‐Hop (Hippocampal‐Horn percentage). Statistical analyzes were performed using Spearman´s Rank correlation coefficient.ResultWe found strongly positive correlation between sleep efficiency and RAVLT (r = 0,73, p < 0,001). There was also positive correlation between RAVLT and percentage of REM sleep (r = 0,49, p < 0,05), but correlation with percentages of non‐REM sleep stages was not sign...
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