An Exploratory Study of the Safety and Efficacy of a Trigonella foenum-graecum Seed Extract in Early Glucose Dysregulation: A Double-Blind Randomized Placebo-Controlled Trial (original) (raw)
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Journal of Nutrition and Metabolism, 2014
This study determined the effects of fenugreek on postprandial plasma glucose (PPG) and satiety among overweight and obese individuals. Fourteen subjects were studied in the morning after overnight fasts on four separate occasions. Glycaemic responses elicited by 50 g carbohydrate portions of white bread and jam with or without 5.5 g of fenugreek and fried rice with or without 5.5 g fenugreek were determined over 2 h. The primary endpoint was the incremental area under the plasma glucose response curve (IAUC). Adding fenugreek to both foods significantly reduced the IAUC compared to the food alone: white bread and jam, 180 ± 22 versus 271 ± 23 mmol × min/L (P= 0.001); fried rice, 176 ± 20 versus 249 ± 25 mmol × min/L (P= 0.001). Fenugreek also significantly reduced the area under the satiety curve for white bread with jam (134 ± 27 versus 232 ± 33 mm × hr,P= 0.01) and fried rice (280 ± 37 versus 379 ± 36 mm × hr,P= 0.01). It is concluded that fenugreek significantly decreased the PP...
Management of newly diagnosed diabetes by Trigonella foenum-graecum
The objective of our study was to determine the role of fenugreek seed powder in the management of newly diagnosed type 2 diabetes. We selected 38 patients with newly diagnosed type 2 diabetes, aged between 30-45 years, without any significant diabetes complications and were grouped as: Group I (n=19) consumed 25 g. fenugreek twice daily (before breakfast and dinner) and on moderate exercise for two months, Group II (n=19) subjects were on dietary control. Blood sample collected before and after the treatment were analyzed for lipid profile and fasting blood sugar (FBS). Atherogenic index of plasma (AIP) was computed for each patient at baseline.The subjects received fenugreek seed powder and on exercise showed significant reduction in the FBS, cholesterol, triglyceride and LDL cholesterol which were statistically significant. There was a significant increase in the HDL cholesterol. The AIP value was statistically significant with subjects who received fenugreek seed powder and on exercise. FBS and triglyceride were reduced with the subjects who were on diet control. Our data showed that the management of type 2 diabetes would be easier with therapeutic approach of fenugreek seeds.
OBM Integrative and Complementary Medicine, 2020
To investigate the blood glucose lowering effect of the seed powder of T. foenum-graecum Linn (Papilionaceae) in normal and alloxan-induced diabetic rabbits. The blood glucose lowering effect of the seed powder was determined in normal and alloxan-induced (100 mg/kg, i.v.) diabetic rabbits, after oral administration of doses of 50, 100 and 150 mg/kg body weight. Blood samples were collected from the marginal ear vein before and also at 4, 6, 8, 10, 12, 16, 18, 20 and 24 h after drug administration and blood glucose was analysed by Nelson-Somogyi's method using a visible spectrophotometer. The data was compared statistically by using Student's t-test. The seed powder of T. foenum-graecum produced a brought to you by CORE View metadata, citation and similar papers at core.ac.uk
Antidiabetic effects of Trigonella foenum-graecum seed powder in a rat model
Toxicological & Environmental Chemistry, 2011
Free radical production and oxidative stress are known to increase in liver during diabetes and may contribute to oxidative damage. In this study, the effect of oral feeding of Trigonella foenum-graecum seed powder (TSP) has been studied on blood glucose, membrane-linked ATPases, antioxidant enzymes, lipid peroxidation, lipofuscin content and membrane fluidity in livers of a diabetic rat. Diabetes was induced by administration of alloxan monohydrate. Hyperglycemia during diabetes has been shown to entail free radical generation, with a concomitant increase in lipid peroxidation and lipofuscin content, inhibition of membrane-linked ATPases, increased antioxidant enzyme activities and decreased membrane fluidity. TSP treatment reverses the changes to near normal levels thereby ameliorating the management of diabetic complications.
Journal of Ethnopharmacology, 1997
The aqueous and alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. Graded amounts (0.06, 0.2, 0.5, 1 g/kg, i.p. and 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonellafoenum-graecum leaf when given to both normal and alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed. On the other hand ethanolic extract of Trigonella foenum-graecum leaf produced no reduction in blood glucose concentration in normal rats but intra-peritoneal administration of 0.8 g/kg of the ethanolic leaf extract to diabetic rats produced a significant reduction of blood glucose concentration (p < 0.02) at 2 and 24 h only. Intraperitoneal and oral acute toxicity (LD50) and target organ effects were studied for the aqueous extract of Trigonella leaf in mice. LD50 of i.p. and oral administration were 1.9 and 10 g/kg respectively. The main organ affected after i.p. administration of the aqueous extract was the liver while oral administration of the aqueous extract of Trigonella did not produce any sign of organ damage. These results suggest that the aqueous extract of Trigonella foenum-graecum leaves given both orally and intraperit0neally possesses a hypoglycaemic effect in normoglycaemic and alloxan induced hyperglycaemic rats, © 1997 Elsevier Science Ireland Ltd.
The effects of ethanol extract of Trigonella foenum-graecum (Fenugreek) seeds on the blood glucose levels in alloxan-induced diabetic rats at different doses (2g/kg, 1g/kg, 0.5g/kg and 0.1g/kg) were studied. The hypoglycemic effect of extract was compared with that of the standard antidiabetic drug (glimepiride, 4mg/kg) single dose. The extract showed significant activity against the diabetic state induced by alloxan but the intensity of hypoglycemic effect varied from dose to dose. The most effective dose recognized was 1g/kg but that is still lower than the standard antidiabetic drug. No acute toxicity was observed for ethanol extract of T. foenum-graecum seed when it was administered orally at high dose level (3 g/kg body weight), which is higher than effective antihyperglycemic dose, and closely observed for 24 hrs for any mortality and next 10 days for any delayed toxic effects on gross behavioral activities. Phytochemical group tests were also accomplished and presence of alkaloids, steroids and carbohydrates were recognized in the extract.
Indian Journal of Pharmaceutical Education and Research
Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well as for its sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and antiinflammatory activities of Trigonella foenum-graecum L. Aim: The purpose of this study was to accentuate on formulation of granules and investigate the effect of germinated Trigonella foenum-graecum L. (TFG) granules in Diabetes mellitus (DM) rats induced by streptozotocin as fenugreek retains hypoglycemic property. Materials and Methods: Granules of germinated TFG powder were arranged by means of several excipients comprising diverse amounts of super disintegrants by (wet) granulation method and proceed for the solid dosage form evaluation. Further, in-vivo study was performed in STZ induced DM Wister rats for four weeks. TFG granules 1600mg/kg and Glibenclamide 0.45 mg/kg (as a positive control for comparison) were orally administrated and evaluate the diabetics in rats. Results: All evaluation parameter are correct: as in standard tablet. The STZ (Streptozotocin) induced rats the treatment with the Drug (Glibenclamide) and TFG granules significantly lowered the blood plasma glucose levels by 36% (mean ± SD glucose 120 ± 0.6 mg/dL (p < 0.001)) and 38% (mean ± SD glucose 114 ± 0.4 mg/dL; p < 0.001) respectively after 4 weeks of treatment when compared to T2DM (Type 2 Diabetes mellitus) rats. Conclusion: Experimental studies had shown that bioactive compounds found in Trigonella Foenum graceum herb have potential to cure diabetes especially due to the presence of unique chemical constituent including trigonelline, galactomannan and amino acid 4-hydroxy isoleucine. These findings suggested that TFG granules may be an alternative medicine for the management of DM.