Origin and Differentiation of Osteoclasts (original) (raw)
Elsevier eBooks, 2020
Abstract
Abstract Bone remodeling occurs through the interactions of two major cell lineages, osteoblasts, which mediates bone formation, and osteoclasts, which mediate bone resorption. This review provides a through introduction to the myeloid precursors of osteoclasts, the signals that induce their differentiation, the signaling pathways and transcription factors that control their differentiation, fusion and resorptive actions.
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