Cord blood bilirubin level as a predictor of development of pathological hyperbilirubinemia in newborns (original) (raw)
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Correlation between cord blood bilirubin level and incidence of hyperbilirubinemia in term newborns
Paediatrica Indonesiana, 2009
Background Discharging healthy term newborns from thehospital after delivery at increasingly earlier postnatal ages hasrecently become a common practice due to medical, social, andeconomic reasons, however it contributes to readmission becauseof jaundice.Objective To investigate the correlation between level of cordblood bilirubin and development of hyperbilirubinemia amonghealthy term newborns.Methods Prospective observational study was performed on88 healthy term newborns. Cord blood was collected for thetotal bilirubin, conjugated bilirubin, unconjugated bilirubinlevel measurement and blood group test. Measurements of totalbilirubin, conjugated bilirubin, and unconjugated bilirubin wererepeated on the 5th day with serum sampling, or as soon as thenewborn appeared to be jaundice.Results Subjects were categorized into hyperbilirubinemia andnon-hyperbilirubinemia newborns. There was a correlationbetween cord blood and the 5th day bilirubin level. By ROCanalysis, cord blood bilirubin...
Predictive Value of Cord Blood Bilirubin in Development of Neonatal Hyperbilirubinemia
Indian Journal of Child Health, 2018
Introduction: The early detection of neonatal hyperbilirubinemia (NNH) can be done by various methods; however, the most reliable is cord blood bilirubin (CBB). Objective: The objective of this study is to evaluate the predictive value of the CBB levels for the subsequent hyperbilirubinemia in healthy term newborns and its association with various maternal and neonatal factors. Materials and Methods: Two hundred healthy term-neonates between 37 and 42 weeks of gestation were included in the study. A thorough antenatal, perinatal, and natal history was obtained. Cord blood was collected from all newborns, and the samples were sent for the estimation of serum bilirubin, blood grouping, and Rh typing. Results: Various risk factors such as gender difference (p<0.05), development of jaundice (p=0.00), extent of jaundice (p=0.00), number of cases requiring referral (p<0.05), and jaundice in siblings (p=0.01) were found statistically significant. Several maternal and neonatal factors such as maternal history of jaundice (p=0.009), gestational hypertension (p=0.01), antepartum hemorrhage (p<0.05), obstructed labor (p=0.009), use of oxytocin (p=0.008), ABO, and Rh incompatibility (p<0.001) were also found statistically significant in relation to CBB >2.5 mg/dl. At a cutoff of 2.5 mg/dl, sensitivity and specificity came out to be 33.33% and 96.25%, respectively. Conclusion: NNH and CBB level were found to be associated with several maternal and neonatal risk factors. Hence, total serum bilirubin in cord blood was indicative of the jaundice severity among neonates.
Pediatrics & Neonatal Biology Open Access, 2018
Objective: The present study was conducted to investigate the predictability of pathological jaundice on cord blood bilirubin values. Methodology: It was a prospective observation study conducted in Kurji holy family hospital on 289 healthy new-borns. Babies were divided into two groups. Group A who developed Physiological Jaundice and Group B who developed pathological jaundice. Cord blood bilirubin was estimated in all newborn who were then followed up-to 5 th day of life. Babies who developed jaundice requiring treatment were admitted in NICU for phototherapy. Rest where checked regularly up-to 5 th day of life and value recorded on 5 th day by estimation of serum bilirubin. Results: Incidence of pathological hyperbilirubinemia in our study was 11.2%. Statistically significant correlation between cord blood bilirubin and development of pathological jaundice. Gender, age, mode of delivery and birth weight has no correlation with cord bilirubin and the subsequent development of jaundice. Cord blood bilirubin <2.5mg/dl when compared with subsequent development of jaundice has high specificity (83.92%) and negative predictive value (87.35 %). Cord blood value of >3.5mg/dl has high sensitivity (97.06%), specificity (99.22%), Positive predictive value (94.29%) and negative predictive value (99.61 %) in predicting future development of future pathological jaundice. Conclusion: 87.35% negative Predictive Value in the present study suggests that in Healthy Term babies (Cord Blood Bilirubin ≤2.5mg/dl) cord serum bilirubin can help to identify those new-borns who are unlikely to require further evaluation and intervention. These new-borns can be discharged with assurance to Parents. Babies with CBB level ≥3mg/dl should be followed more frequently. Thus, this study concludes that cord blood total bilirubin levels reliably predict the occurrence of pathological hyperbilirubinemia.
https://www.ijrrjournal.com/IJRR\_Vol.8\_Issue.6\_June2021/IJRR-Abstract03.html, 2021
Background: Infants who are clinically jaundiced in the first few days are more likely to develop hyperbilirubinemia. Hyperbilirubinemia is the most common medical problem in newborn infants. It is the most important cause for hospital readmissions during the early neonatal period and also the cause for neonatal morbidity. Objective: In this prospective study we are going to evaluate the predictive value of cord bilirubin level for identifying term neonates for subsequent hyperbilirubinemia. Materials and Methods: Cord bilirubin levels at birth and subsequently serum bilirubin levels at 72 h were assessed in 291 neonates. The cutoff value was estimated beyond which there was significant hyperbilirubinemia. Statistics employed include quantitative data which is expressed in terms of mean and SD and qualitative in terms of proportions and receiver operator characteristic curve used to find cutoff value and to find sensitivity and specificity. Results: The cutoff value of cord bilirubin >2 mg/dl had sensitivity and specificity of 77.97 and 56.90%, respectively, with positive predictive value of 31.51 and negative predictive value of 91.03% for subsequent hyperbilirubinemia. Conclusion: To decreases the significant burden of untreated severe neonatal jaundice, cord serum bilirubin can be used as a screening tool to identify the neonatal jaundice in term and this prediction of neonatal hyperbilirubinemia has widespread implication especially in our country where there are limited resources.
Study of Correlation of Cord Blood Bilirubin with Neonatal Hyperbilirubinemia
MVP Journal of Medical Sciences, 2016
Introduction: Neonatal Hyperbilirubinemia (NH) is a universal problem affecting nearly 60% of term and 80% of preterm neonates during first week of life. Early discharge of healthy term newborns is a common practice because of medical, social and economic constraints. Insignificant number (6.5%) of babies, NH is a cause for readmission. The present study was conducted to correlate the Cord Blood Bilirubin (CBB) level with subsequent NH. Methods: Study was performed at the Department of Pediatrics in a Medical College Hospital and Research Centre. Intramurally delivered, 113 Healthy full-term newborns during 1-year period were prospectively enrolled. CBB was estimated. Serum Bilirubin estimation was done at 48 hours and 5 day of age and later if required. Results: Significant NH in our study is 3.5%. Mean total bilirubin on second postnatal day was 10.58 mg/dl and on fifth post natal day was 10.81 mg/dl. Using CBB level of ≥3 mg/dl as a cut-off, NH can be predicted with sensitivity o...
Correlation of cord blood bilirubin and neonatal hyperbilirubinemia in healthy newborns
International Journal of Contemporary Pediatrics, 2016
Background: Jaundice is one of the commonest problems that can occur in a newborn. During the first week of life all new-borns have increased bilirubin levels by adult standards, with approximately 60% of term babies 1 and 85% of preterm babies having visible jaundice. This physiological rise in bilirubin causes indirect hyperbilirubinemia after 24 hours of birth, rises progressively with age and resolves gradually with no intervention in majority of cases. A small percentage may however require phototherapy or exchange transfusion when the bilirubin levels exceed the normal range.
Paediatrica Indonesiana, 2019
Background Early discharge of healthy term newborns after delivery has become a common practice, because of medical and social reasons, as well as economic constraints. Thus, the recognition, follow-up, and early treatment of jaundice has become more difficult as a result of early discharge from the hospital. Since the dreaded complication of neonatal hyperbilirubinemia is kernicterus, an investigation which can predict the future onset of neonatal pathological jaundice is needed. Objective To investigate the predictability of neonatal hyperbilirubinemia by using cord blood bilirubin, albumin and bilirubin/albumin ratio. Methods This study was conducted on 300 healthy newborns. Umbilical cord blood was used to measure albumin and bilirubin. All infants were regularly followed up to 5th day of life. Neonates were divided into two groups: group A was consisted of neonates who developed jaundice which was in physiological range, while group B was consisted of neonates who developed neo...
Bangladesh Journal of Child Health, 2010
The present study was conducted to investigate the predictability of early serumbilirubin levels on the subsequent development of neonatal hyperbilirubinemia. Forthis purpose 84 healthy newborn infants were enrolled and followed up for first 5 daysof life. Study subjects were divided into two groups. Group-I consisted of 71 subjects,who did not develop significant hyperbilirubinemia (bilirubin <17mg/dl); Group-IIconsisted of 13 newborns, who developed significant hyperbilirubinemia (bilirubin >17mg/dl) during the follow up. Of the enrolled subjects, 46 (55%) were male and rest 38(45%) were female; 64 (76%) were term babies and 20 (24%) were pre-term babies.Significantly higher percentage of pre-term babies developed hyperbilirubinemia. ROC(receiver operating characteristic) analysis demonstrates that the critical value ofcord blood bilirubin >2.5mg/dl had the high sensitivity (77%) and specificity (98.6%)to predict the newborn who would develop significant hyperbilirubinemi...
Cord Bilirubin Levels as a Predictive Marker for Neonatal Hyperbilirubinemia: A Prospective Study
Indian Journal of Child Health, 2017
Hyperbilirubinemia is the most common medical problem in newborn infants. Early discharge is recommended but hospital readmission is a cause of concern among clinicians ,and early discharge of neonates is recommended. This inturn carries a risk of delayed recognition of significant hyperbilirubinemia.A cross-sectional analytical study was done primarily to evaluate the predictive value of cord bilirubin level for identifying term and near term neonates for subsequent hyperbilirubinemia. Materials & Methods Cord bilirubin levels at birth and subsequently serum bilirubin levels at 72 hours were assessed in 100 neonates. The cut off value was estimated beyond which there was significant hyperbilirubinemia. Result The cut off value of cord bilirubin >2.02 mg/dl had sensitivity and specificity of 87.5% and 70.8% respectively with positive predictive value of 0.39 and negative predictive value of 0.965 for subsequent hyperbilirubinemia. Conclusion The cutoff value of cord bilirubin level estimated is 2.02 mg/dl can be used to predict significant neonatal hyperbilirubinemia.
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2020
Introduction. Around 80 percent of preterm infants and 60 percent of term infants are affected by neonatal jaundice in the first week of life. Early discharge of healthy term infants is a common practice because of economic constraints and social reasons. Which new-borns are at increased risk for developing significant hyperbilirubinemia (Total serum bilirubin ≥ 15mg/dl) is difficult to predict. This study was taken up to evaluate the predictive value of cord blood bilirubin level for identifying term infants for subsequent hyperbilirubinemia. Material and methods. This prospective observational study was conducted in Adichunchanagiri Institute of Medical Sciences, Mandya, Karnataka from 1st of April 2020 to 30th September 2020. 100 healthy term babies satisfying the eligibility criteria and born in the study period were included in the study. Umbilical cord blood was collected and was correlated with serum bilirubin levels at 48hours of life. Significant hyperbilirubinemia was take...