Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor (original) (raw)

Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review

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Translational potential of allosteric modulators targeting the cannabinoid CB1 receptor

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In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

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Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

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Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

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Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB 2 Receptor Derived from the Natural Product Cannabidiol

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Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

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Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist

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A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models

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Novel approaches and current challenges with targeting the endocannabinoid system

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Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors

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Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats

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Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists

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Should peripheral CB 1 cannabinoid receptors be selectively targeted for therapeutic gain

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A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects

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Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor

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Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation

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Molecular Pharmacology of CB1 and CB2 Cannabinoid Receptors

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Exploring the Benzimidazole Ring as a Substitution for Indole in Cannabinoid Allosteric Modulators

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Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands

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Novel selective cannabinoid CB1 receptor antagonist MJ08 with potent in vivo bioactivity and inverse agonistic effects

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Functional Selectivity in CB2 Cannabinoid Receptor Signaling and Regulation: Implications for the Therapeutic Potential of CB2 Ligands

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Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

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