The L444PGBAmutation is associated with early-onset Parkinson's disease in Mexican Mestizos (original) (raw)

The study examines the prevalence and impact of the L444P GBA mutation in early-onset Parkinson's disease (PD) within a sample of Mexican Mestizo patients. Among 128 patients with early-onset PD, the L444P mutation was identified in 5.5% of patients with no occurrences in control groups, suggesting a significant association with the disease. Additionally, the presence of the mutation correlated with a higher incidence of psychiatric symptoms and cognitive decline, supporting the notion that GBA mutations may contribute more to PD pathology than previously understood.